Evaluating the Effects of Dietary Interventions on Disease Progression and Symptoms of Adults with Multiple Sclerosis: An Umbrella Review

Macaron, 2019, Diagnosis and management of progressive multiple sclerosis, Biomedicines, 7, 56, 10.3390/biomedicines7030056 Browne, 2014, Atlas of multiple sclerosis 2013: a growing global problem with widespread inequity, Neurology, 83, 1022, 10.1212/WNL.0000000000000768 Dendrou, 2015, Immunopathology of multiple sclerosis, Nat Rev Immunol, 15, 545, 10.1038/nri3871 Penesová, 2018, Nutritional intervention as an essential part of multiple sclerosis treatment?, Physiol Res, 67, 521, 10.33549/physiolres.933694 Moher, 2009, Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement, PLoS Med, 6, e1000097, 10.1371/journal.pmed.1000097 6 Aromataris E, Fernandez RS, Godfrey C, Holly C, Khalil H, Tungpunkom P,. Methodology for JBI umbrella reviews. In: Aromataris E. (Ed.) Joanna Briggs Institute Reviewers' Manual: 2014 edition (supplement). South Australia: The Joanna Briggs Institute; 2014. p. 1–34. 7 Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA, editors. Cochrane handbook for systematic reviews of interventions version 6.0 [updated July 2019] [Internet]. Cochrane Collaboration; 2019; [cited 2020 Jan]. Available from: www.training.cochrane.org/handbook,. Kurtzke, 1983, Rating neurologic impairment in multiple sclerosis: an Expanded Disability Status Scale (EDSS), Neurology, 33, 1444, 10.1212/WNL.33.11.1444 Kurtzke, 1961, On the evaluation of disability in multiple sclerosis, Neurology, 11, 686, 10.1212/WNL.11.8.686 Krupp, 1989, The Fatigue Severity Scale: application to patients with multiple sclerosis and systemic lupus erythematosus, Arch Neurol, 46, 1121, 10.1001/archneur.1989.00520460115022 Schwartz, 1993, The measurement of fatigue: a new instrument, J Psychosom Res, 37, 753, 10.1016/0022-3999(93)90104-N >12 Shahid A, Wilkinson K, Marcu S, Shapiro CM,. Fatigue Impact Scale (FIS). In: Shahid A, Wilkinson K, Marcu S, Shapiro CM, editors. STOP, THAT and one hundred other sleep scales. New York: Springer New York; 2012. p. 163–5. Larson, 2013, Psychometric properties of the modified fatigue impact scale, Int J MS Care, 15, 15, 10.7224/1537-2073.2012-019 >14 Higgins JPT, Green S, editors. Cochrane handbook for systematic reviews of interventions version 5.1.0 [updated March 2011]. The Cochrane Collaboration; 2011; [cited 2019 Aug 1] [Internet]. Available from: www.handbook.cochrane.org,. >15 Food Standards Australia New Zealand. AUSNUT 2011–13 Australian Food, Supplement and Nutrient Database [Internet]. Canberra (Australia): FSANZ; 2014; [updated 2014 Sep] [cited 2020 Jan]. Available from: www.foodstandards.gov.au,. Petrovskaya, 2019, Synthesising evidence on patient portals: a protocol for an umbrella review, BMJ Open, 9, e024469, 10.1136/bmjopen-2018-024469 Pollock, 2017, Selecting and implementing overview methods: implications from five exemplar overviews, Syst Rev, 6, 145, 10.1186/s13643-017-0534-3 Shea, 2017, AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both, BMJ, 358, j4008, 10.1136/bmj.j4008 Higgins, 2011, The Cochrane Collaboration's tool for assessing risk of bias in randomised trials, BMJ, 343, d5928, 10.1136/bmj.d5928 Khan, 2012, Systematic reviews to evaluate causation: an overview of methods and application, Evid Based Med, 17, 137, 10.1136/ebmed-2011-100287 Atkins, 2005, Systems for grading the quality of evidence and the strength of recommendations II: pilot study of a new system, BMC Health Serv Res, 5, 25, 10.1186/1472-6963-5-25 Jagannath, 2018, Vitamin D for the management of multiple sclerosis, Cochrane Database Syst Rev, 9, CD008422 Hempel, 2017, A systematic review of the effects of modifiable risk factor interventions on the progression of multiple sclerosis, Mult Scler, 23, 513, 10.1177/1352458517690271 Farinotti, 2012, Dietary interventions for multiple sclerosis, Cochrane Database Syst Rev, 12, Cd004192 Tejani, 2012, Carnitine for fatigue in multiple sclerosis, Cochrane Database Syst Rev, 5, CD007280 Ganesh, 2013, The case for vitamin D supplementation in multiple sclerosis, Mult Scler Relat Disord, 2, 281, 10.1016/j.msard.2012.12.008 Berezowska, 2019, Effectiveness of vitamin D supplementation in the management of multiple sclerosis: a systematic review, Int J Mol Sci, 20, E1301, 10.3390/ijms20061301 Bagur, 2017, Influence of diet in multiple sclerosis: a systematic review, Adv Nutr, 8, 463, 10.3945/an.116.014191 Sintzel, 2018, Vitamin D and multiple sclerosis: a comprehensive review, Neurol Ther, 7, 59, 10.1007/s40120-017-0086-4 Luque-Cordoba, 2017, Metabolomics: a potential way to know the role of vitamin D on multiple sclerosis, J Pharm Biomed Anal, 136, 22, 10.1016/j.jpba.2016.12.023 Brown, 2006, The role of vitamin D in multiple sclerosis, Ann Pharmacother, 40, 1158, 10.1345/aph.1G513 Goldsmith, 2015, Vitamin D as an immunomodulator: risks with deficiencies and benefits of supplementation, Healthcare (Basel), 3, 219, 10.3390/healthcare3020219 >33 Veauthier C, Paul F,. [Therapy of fatigue in multiple sclerosis: a treatment algorithm.]. Nervenarzt. 2016;87(12):1310–21.(in German). McKay, 2017, Factors associated with onset, relapses or progression in multiple sclerosis: a systematic review, Neurotoxicology, 61, 189, 10.1016/j.neuro.2016.03.020 Shahbeigi, 2013, Vitamin D3 concentration correlates with the severity of multiple sclerosis, Int J Prev Med, 4, 585 Harandi, 2012, Association of serum 25(OH) vitamin D3 concentration with severity of multiple sclerosis, Iran J Neurol, 11, 54 Weinstock-Guttman, 2011, Vitamin D metabolites are associated with clinical and MRI outcomes in multiple sclerosis patients, J Neuro Neurosurg Psychiatry, 82, 189, 10.1136/jnnp.2010.227942 Smolders, 2008, Association of vitamin D metabolite levels with relapse rate and disability in multiple sclerosis, Mult Scler, 14, 1220, 10.1177/1352458508094399 Mowry, 2012, Vitamin D status predicts new brain magnetic resonance imaging activity in multiple sclerosis, Ann Neurol, 72, 234, 10.1002/ana.23591 >40 Neau JP, Artaud-Uriot MS, Lhomme V, Bounaud JY, Lebras F, Boissonnot L, Moinot N, Ciron J, Larrieu D, Mathis S, et al. [Vitamin D and multiple sclerosis. A prospective survey of patients of Poitou-Charentes area.]. Rev Neurol (Paris). 2011;167(4):317–23.(in French). Loken-Amsrud, 2012, Vitamin D and disease activity in multiple sclerosis before and during interferon-beta treatment, Neurology, 79, 267, 10.1212/WNL.0b013e31825fdf01 Runia, 2012, Lower serum vitamin D levels are associated with a higher relapse risk in multiple sclerosis, Neurology, 79, 261, 10.1212/WNL.0b013e31825fdec7 Simpson, 2010, Higher 25-hydroxyvitamin D is associated with lower relapse risk in multiple sclerosis, Ann Neurol, 68, 193 Langer-Gould, 2011, Vitamin D, pregnancy, breastfeeding, and postpartum multiple sclerosis relapses, Arch Neurol, 68, 310, 10.1001/archneurol.2010.291 Soilu-Hänninen, 2008, A longitudinal study of serum 25-hydroxyvitamin D and intact parathyroid hormone levels indicate the importance of vitamin D and calcium homeostasis regulation in multiple sclerosis, J Neurol Neurosurg Psychiatry, 79, 152, 10.1136/jnnp.2006.105320 >46 Rodenas Esteve I, Wanden-Berghe C, Sanz-Valero J,. [Effects of nutritional status on the multiple sclerosis disease: systematic review.]. Nutr Hosp. 2018;35(1):211–23.(in Spanish). Burton, 2015, Vitamin D in multiple sclerosis and central nervous system demyelinating disease—a review, J Neuroophthalmol, 35, 194, 10.1097/WNO.0000000000000256 Kočovská, 2017, Vitamin-D deficiency as a potential environmental risk factor in multiple sclerosis, schizophrenia, and autism, Front Psychiatry, 8, 47, 10.3389/fpsyt.2017.00047 Hanwell, 2011, Assessment of evidence for a protective role of vitamin D in multiple sclerosis, Biochim Biophys Acta, 1812, 202, 10.1016/j.bbadis.2010.07.017 D’Hooghe M, 2010, Modifiable factors influencing relapses and disability in multiple sclerosis, Mult Scler, 16, 773, 10.1177/1352458510367721 Eikelenboom, 2009, Gender differences in multiple sclerosis: cytokines and vitamin D, J Neurol Sci, 286, 40, 10.1016/j.jns.2009.06.025 Coyle, 2016, Symptom management and lifestyle modifications in multiple sclerosis, Continuum, 22, 815 Carlson, 2013, Vitamin D as a clinical biomarker in multiple sclerosis, Expert Opin Med Diagn, 7, 231, 10.1517/17530059.2013.772978 Hewer, 2013, Vitamin D and multiple sclerosis, J Clin Neurosci, 20, 634, 10.1016/j.jocn.2012.10.005 Munger, 2011, Prevention and treatment of MS: studying the effects of vitamin D, Mult Scler, 17, 1405, 10.1177/1352458511425366 Mische, 2018, The evidence for dietary interventions and nutritional supplements as treatment options in multiple sclerosis: a review, Curr Treat Options Neurol, 20, 8, 10.1007/s11940-018-0494-5 >57 Cendrowski W,. [Importance of lipids in pathological mechanisms of multiple sclerosis.]. Neurol Neurochir Pol. 1975;9(2):253–8.(in Polish). Crabtree-Hartman, 2018, Advanced symptom management in multiple sclerosis, Neurol Clin, 36, 197, 10.1016/j.ncl.2017.08.015 Schmitz, 2015, “Disease modifying nutricals” for multiple sclerosis, Pharmacol Ther, 148, 85, 10.1016/j.pharmthera.2014.11.015 Altowaijri, 2017, Dietary interventions and multiple sclerosis, Curr Neurol Neurosci Rep, 17, 28, 10.1007/s11910-017-0732-3 Farzaei, 2017, Efficacy and tolerability of phytomedicines in multiple sclerosis patients: a review, CNS Drugs, 31, 867, 10.1007/s40263-017-0466-4 Claflin, 2018, Complementary and alternative treatments of multiple sclerosis: a review of the evidence from 2001 to 2016, J Neurol Neurosurg Psychiatry, 89, 34, 10.1136/jnnp-2016-314490 Pommerich, 2018, Is there an effect of dietary intake on MS-related fatigue? A systematic literature review, Mult Scler Relat Disord, 25, 282, 10.1016/j.msard.2018.08.017 Plemel, 2015, Over-the-counter anti-oxidant therapies for use in multiple sclerosis: a systematic review, Mult Scler, 21, 1485, 10.1177/1352458515601513 Khalili, 2014, Does lipoic acid consumption affect the cytokine profile in multiple sclerosis patients: a double-blind, placebo-controlled, randomized clinical trial, Neuro Immuno Modulation, 21, 291 de Sousa, 2019, Alpha-lipoic acid in the treatment of psychiatric and neurological disorders: a systematic review, Metab Brain Dis, 34, 39, 10.1007/s11011-018-0344-x Yadav, 2005, Lipoic acid in multiple sclerosis: a pilot study, Mult Scler, 11, 159, 10.1191/1352458505ms1143oa Sanadgol, 2017, Recent updates in imperative natural compounds for healthy brain and nerve function: a systematic review of implications for multiple sclerosis, Curr Drug Targets, 18, 1499, 10.2174/1389450118666161108124414 Salari, 2015, Zinc sulphate: a reasonable choice for depression management in patients with multiple sclerosis. A randomized, double-blind, placebo-controlled clinical trial, J Pharmacol Rep, 67, 606, 10.1016/j.pharep.2015.01.002 Fragoso, 2014, The evidence for a beneficial role of vitamin A in multiple sclerosis, CNS Drugs, 28, 291, 10.1007/s40263-014-0148-4 Nemazannikova, 2018, Is there a link between vitamin B and multiple sclerosis?, Med Chem, 14, 170, 10.2174/1573406413666170906123857 Khosravi-Largani, 2018, A review on potential roles of vitamins in incidence, progression, and improvement of multiple sclerosis, eNurologicalSci, 10, 37, 10.1016/j.ensci.2018.01.007 Naghashpour, 2017, Update on riboflavin and multiple sclerosis: a systematic review, Iran J Basic Med Sci, 20, 958 Bitarafan, 2015, Impact of vitamin a supplementation on disease progression in patients with multiple sclerosis, Arch Iran Med, 18, 435 Jafarirad, 2013, The effect of vitamin a supplementation on biochemical parameters in multiple sclerosis patients, Iran Red Crescent Med J, 15, 194, 10.5812/ircmj.3480 Naghashpour, 2013, Riboflavin supplementation to patients with multiple sclerosis does not improve disability status nor is riboflavin supplementation correlated to homocysteine, Int J Vitam Nutr Res, 83, 281, 10.1024/0300-9831/a000170 >77 Bisaga GN, Odinak MM, Boiko AN, Mel’nik IB, Popova NF,. [Possibilities of treatment of multiple sclerosis exacerbations without corticosteroids: a role of metabolic and antioxidant therapy.] Zh Nevrol Psikhiatr Im S S Korsakova. 2011;111(2):44–8.(in Russian). Sedel, 2015, High doses of biotin in chronic progressive multiple sclerosis: a pilot study, Mult Scler Relat Disord, 4, 159, 10.1016/j.msard.2015.01.005 Tourbah, 2016, MD1003 (high-dose biotin) for the treatment of progressive multiple sclerosis: a randomised, double-blind, placebo-controlled study, Mult Scler, 22, 1719, 10.1177/1352458516667568 Saka, 2012, Nutritional status and anthropometric measurements of patients with multiple sclerosis, Saudi Med J, 33, 160 Shinto, 2008, A randomized pilot study of naturopathic medicine in multiple sclerosis, J Altern Complement Med, 14, 489, 10.1089/acm.2007.0757 Wade, 2002, A randomised placebo controlled exploratory study of vitamin B-12, lofepramine, and L-phenylalanine (the “Cari Loder regime”) in the treatment of multiple sclerosis, J Neurol Neurosurg Psychiatry, 73, 246, 10.1136/jnnp.73.3.246 Likosky, 1991, Intense immunosuppression in chronic progressive multiple sclerosis: the Kaiser study, J Neurol Neurosurg Psychiatry, 54, 1055, 10.1136/jnnp.54.12.1055 Kira, 1994, Vitamin B12 metabolism and massive-dose methyl vitamin B12 therapy in Japanese patients with multiple sclerosis, Intern Med, 33, 82, 10.2169/internalmedicine.33.82 Besler, 2002, Serum levels of antioxidant vitamins and lipid peroxidation in multiple sclerosis, Nutr Neurosci, 5, 215, 10.1080/10284150290029205 Løken-Amsrud, 2013, Retinol levels are associated with magnetic resonance imaging outcomes in multiple sclerosis, Mult Scler, 19, 451, 10.1177/1352458512457843 Bitarafan, 2014, Dietary intake of nutrients and its correlation with fatigue in multiple sclerosis patients, Iran J Neurol, 13, 28 Ayache, 2017, Fatigue in multiple sclerosis—insights into evaluation and management, Neurophysiol Clin, 47, 139, 10.1016/j.neucli.2017.02.004 Mehrabani, 2019, Effect of coenzyme Q10 supplementation on fatigue: a systematic review of interventional studies, Complement Ther Med, 43, 181, 10.1016/j.ctim.2019.01.022 Yadav, 2006, Complementary and alternative medicine: is there a role in multiple sclerosis?, Curr Neurol Neurosci Rep, 6, 259, 10.1007/s11910-006-0014-y von Geldern, 2012, The influence of nutritional factors on the prognosis of multiple sclerosis, Nat Rev Neurol, 8, 678, 10.1038/nrneurol.2012.194 Dolan, 2016, Probiotics and disease: a comprehensive summary—part 1, mental and neurological health, Integr Med (Encinitas), 15, 46 de Oliveira, 2017, Intestinal dysbiosis and probiotic applications in autoimmune diseases, Immunology, 152, 1, 10.1111/imm.12765 Labuschagne, 2018, An anti-inflammatory approach to the dietary management of multiple sclerosis: a condensed review, South Afr J Clin Nutr, 31, 67, 10.1080/16070658.2018.1465652 Thomsen, 2019, The role of gluten in multiple sclerosis: a systematic review, Mult Scler Relat Disord, 27, 156, 10.1016/j.msard.2018.10.019 D’Hooghe, 2010, Modifiable factors influencing relapses and disability in multiple sclerosis, Mult Scler, 16, 773, 10.1177/1352458510367721 Wahls, 2019, Review of two popular eating plans within the multiple sclerosis community: low saturated fat and modified Paleolithic, Nutrients, 11, 352, 10.3390/nu11020352 Feinstein, 2014, The link between multiple sclerosis and depression, Nat Rev Neurol, 10, 507, 10.1038/nrneurol.2014.139 Sharif, 2017, Coffee and autoimmunity: more than a mere hot beverage!, Autoimmun Rev, 16, 712, 10.1016/j.autrev.2017.05.007 Katz Sand, 2018, The role of diet in multiple sclerosis: mechanistic connections and current evidence, Curr Nutr Rep, 7, 150, 10.1007/s13668-018-0236-z Jahromi, 2014, Islamic fasting and multiple sclerosis, BMC Neurol, 14, 56, 10.1186/1471-2377-14-56 Moss, 2017, Wellness and the role of comorbidities in multiple sclerosis, Neurotherapeutics, 14, 999, 10.1007/s13311-017-0563-6 Swank, 2003, Review of MS patient survival on a Swank low saturated fat diet, Nutrition, 19, 161, 10.1016/S0899-9007(02)00851-1 McLaughlin, 2018, Vitamin D for the treatment of multiple sclerosis: a meta-analysis, J Neurol, 265, 2893, 10.1007/s00415-018-9074-6 Mihrshahi, 2014, Challenges and opportunities with communicating the results of studies related to fruit and vegetable consumption for general wellbeing and mental health, Australasian Epidemiologist, 21, 8 World Health Organization, 2018