Ethanol decreases plasma sulphydryls in man: effect of disulfiram

European Journal of Clinical Investigation - Tập 18 Số 4 - Trang 420-424 - 1988
Jean‐Marc Burgunder1, Joachim Nelles2, M Bilzer3, Bernhard H. Lauterburg3
1Department of Clinical Pharmacology, University of Berne, Switzerland.
2*Psychiatry, University of Berne, CH-3010 Berne, Switzerland
3Departments of Clinical Pharmacology, Switzerland

Tóm tắt

Abstract Based on animal experiments, interactions of ethanol and its metabolites with sulphydryls have been implicated in the toxicity of ethanol, but acute effects of ethanol on sulphydryls have not been documented in man. Plasma free glutathione and cysteine were therefore measured following the administration of 0·2 g kg‐1ethanol to normal healthy volunteers and chronic alcoholics on disulfiram, where the effects of high concentrations of acetaldehyde can be observed. In both groups, plasma glutathione decreased shortly following ethanol, and a sustained decrease in glutathione was seen in the subjects on disulfiram. In patients on disulfiram, but not the healthy controls, plasma cysteine decreased significantly. The decrease in plasma cysteine was correlated to the rise in acetaldehyde, suggesting that cysteine, but not glutathione, forms an adduct with acetaldehyde in man. We conclude that even moderate doses of ethanol may disturb the sulphydryl homeostasis and could interfere with biologically important processes that depend on sulphydryl groups.

Từ khóa


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Thông tin xuất bản

European Journal of Clinical Investigation

Tập 18 Số 4

420-424

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