Ung thư thực quản và khớp thực quản-dạ dày, Phiên bản 2.2019, Hướng dẫn thực hành lâm sàng NCCN trong ung thư học
Tóm tắt
Ung thư thực quản là nguyên nhân thứ sáu dẫn đến tử vong liên quan đến ung thư trên toàn cầu. Carcinoma biểu mô vảy là loại hình tổn thương phổ biến nhất ở Đông Âu và Châu Á, trong khi adenocarcinoma lại phổ biến nhất ở Bắc Mỹ và Tây Âu. Phẫu thuật là một phần quan trọng trong điều trị ung thư thực quản và khớp thực quản-dạ dày (EGJ) có thể cắt bỏ nhưng tiến triển tại chỗ, và các thử nghiệm ngẫu nhiên đã chỉ ra rằng việc bổ sung hóa trị xạ tiền phẫu hoặc hóa trị trong suốt phẫu thuật có thể cải thiện đáng kể khả năng sống sót. Các liệu pháp nhắm mục tiêu như trastuzumab, ramucirumab và pembrolizumab đã mang lại kết quả đầy hứa hẹn trong việc điều trị bệnh nhân bị bệnh tiến triển hoặc di căn. Quản lý bằng đội ngũ đa ngành là rất cần thiết cho tất cả các bệnh nhân mắc bệnh ung thư thực quản và EGJ. Bộ chọn lọc từ Hướng dẫn NCCN về ung thư thực quản và khớp thực quản-dạ dày này tập trung vào việc khuyến nghị quản lý adenocarcinoma thực quản và EGJ tiến triển tại chỗ và di căn.
Từ khóa
#ung thư thực quản #khớp thực quản-dạ dày #adenocarcinoma #hóa trị #liệu pháp nhắm mục tiêu #quản lý đa ngànhTài liệu tham khảo
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