Ung thư thực quản và khớp thực quản-dạ dày, Phiên bản 2.2019, Hướng dẫn thực hành lâm sàng NCCN trong ung thư học

Journal of the National Comprehensive Cancer Network : JNCCN - Tập 17 Số 7 - Trang 855-883 - 2019
Jaffer A. Ajani1, Thomas A. D’Amico2, David J. Bentrem3, Joseph Chao4, Carlos U. Corvera5, Prajnan Das1, Crystal S. Denlinger6, Peter C. Enzinger7, Paul T. Fanta8, Farhood Farjah9, Hans Gerdes10, Michael K. Gibson11, Robert E. Glasgow12, James A. Hayman13, Steven N. Hochwald14, Wayne L. Hofstetter1, David H. Ilson10, Dawn E. Jaroszewski15, Kimberly L. Johung16, Rajesh N. Keswani3, Lawrence Kleinberg17, Stephen Leong18, Quan P. Ly19, Kristina A. Matkowskyj20, Michael J. McNamara21, Mary F. Mulcahy3, Ravi Kumar Paluri22, Haeseong Park23, Kyle A. Perry24, José M. Pimiento25, George A. Poultsides26, Robert E. Roses27, Vivian E. Strong10, Georgia L. Wiesner11, Christopher G. Willett2, Cameron D. Wright28, Nicole R. McMillian29, Lenora A. Pluchino29
11The University of Texas MD Anderson Cancer Center;
22Duke Cancer Institute;
33Robert H. Lurie Comprehensive Cancer Center of Northwestern University;
44City of Hope National Medical Center;
55UCSF Helen Diller Family Comprehensive Cancer Center;
66Fox Chase Cancer Center;
77Dana-Farber/Brigham and Women’s Cancer Center;
8University of california at San Diego
9Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance;
1010Memorial Sloan Kettering Cancer Center;
1111Vanderbilt-Ingram Cancer Center;
1212Huntsman Cancer Institute at the University of Utah;
1313University of Michigan Rogel Cancer Center;
1414Roswell Park Comprehensive Cancer Center;
1515Mayo Clinic Cancer Center.
1616Yale Cancer Center/Smilow Cancer Hospital;
1717The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins;
1818University of Colorado Cancer Center;
1919Fred & Pamela Buffett Cancer Center;
2020University of Wisconsin Carbone Cancer Center;
2121Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute;
2222O'Neal Comprehensive Cancer Center at UAB;
2323Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine;
2424The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute;
2525Moffitt Cancer Center;
2626Stanford Cancer Institute;
2727Abramson Cancer Center at the University of Pennsylvania;
2828Massachusetts General Hospital Cancer Center; and
2929National Comprehensive Cancer Network

Tóm tắt

Tóm tắt

Ung thư thực quản là nguyên nhân thứ sáu dẫn đến tử vong liên quan đến ung thư trên toàn cầu. Carcinoma biểu mô vảy là loại hình tổn thương phổ biến nhất ở Đông Âu và Châu Á, trong khi adenocarcinoma lại phổ biến nhất ở Bắc Mỹ và Tây Âu. Phẫu thuật là một phần quan trọng trong điều trị ung thư thực quản và khớp thực quản-dạ dày (EGJ) có thể cắt bỏ nhưng tiến triển tại chỗ, và các thử nghiệm ngẫu nhiên đã chỉ ra rằng việc bổ sung hóa trị xạ tiền phẫu hoặc hóa trị trong suốt phẫu thuật có thể cải thiện đáng kể khả năng sống sót. Các liệu pháp nhắm mục tiêu như trastuzumab, ramucirumab và pembrolizumab đã mang lại kết quả đầy hứa hẹn trong việc điều trị bệnh nhân bị bệnh tiến triển hoặc di căn. Quản lý bằng đội ngũ đa ngành là rất cần thiết cho tất cả các bệnh nhân mắc bệnh ung thư thực quản và EGJ. Bộ chọn lọc từ Hướng dẫn NCCN về ung thư thực quản và khớp thực quản-dạ dày này tập trung vào việc khuyến nghị quản lý adenocarcinoma thực quản và EGJ tiến triển tại chỗ và di căn.

Từ khóa

#ung thư thực quản #khớp thực quản-dạ dày #adenocarcinoma #hóa trị #liệu pháp nhắm mục tiêu #quản lý đa ngành

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