Escherichia coli ST131- H 22 as a Foodborne Uropathogen

mBio - Tập 9 Số 4 - 2018
Cindy M. Liu1,2,3, Marc Stegger1,4, Maliha Aziz1,3, Timothy J. Johnson5, Kara Waits3, Lora Nordstrom3, Lori Gauld6, Brett Weaver3,6, Diana Rolland6, Sally Statham3, Joseph Horwinski3, Sanjeev Sariya1, Gregg S. Davis1, Evgeni V. Sokurenko7, Paul Keim2, James R. Johnson8,9, Lance B. Price1,3
1Antibiotic Resistance Action Center, Department of Environmental and Occupational Health, Milken Institute School of Public Health, George Washington University, Washington, DC, USA
2Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, Arizona, USA
3Division of Pathogen Genomics, Translational Genomics Research Institute, Flagstaff, Arizona, USA
4Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, Denmark
5Department of Veterinary and Biomedical Sciences, college of veterinary medicine, University of Minnesota, St. Paul, Minnesota, USA
6Flagstaff Medical Center, Flagstaff, Arizona, USA
7Department of Microbiology, University of Washington School of Medicine, Seattle, Washington USA
8Minneapolis Veterans Affairs Health Care System, Minneapolis, Minnesota, USA
9University of Minnesota Minneapolis, Minnesota, USA

Tóm tắt

E. coli ST131 is an important extraintestinal pathogen that can colonize the gastrointestinal tracts of humans and food animals. Here, we combined detection of accessory traits associated with avian adaptation (ColV plasmids) with high-resolution phylogenetics to quantify the portion of human infections caused by ST131 strains of food animal origin. Our results suggest that one ST131 sublineage—ST131- H 22—has become established in poultry populations around the world and that meat may serve as a vehicle for human exposure and infection. ST131- H 22 is just one of many E. coli lineages that may be transmitted from food animals to humans. Additional studies that combine detection of host-associated accessory elements with phylogenetics may allow us to quantify the total fraction of human extraintestinal infections attributable to food animal E. coli strains.

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