Eradication of spontaneous malignancy by local immunotherapy

Idit Sagiv-Barfi1, Debra K. Czerwinski1, Shoshana Levy1, Israt S. Alam2, Aaron T. Mayer2, Sanjiv S. Gambhir2, Ronald Levy1
1Division of Oncology, Department of Medicine, Stanford University, Stanford, CA 94305, USA.
2Department of Radiology, Molecular Imaging Program at Stanford (MIPS), Stanford University, Stanford, CA, 94305, USA

Tóm tắt

In situ vaccination with low doses of TLR ligands and anti-OX40 antibodies can cure widespread cancers in preclinical models.

Từ khóa


Tài liệu tham khảo

10.1038/10503

10.1073/pnas.95.3.1178

10.4049/jimmunol.179.3.1427

10.1182/blood-2007-01-070748

10.1016/j.immuni.2005.01.016

10.1016/S0002-9440(10)63568-7

C. T. Guy, R. D. Cardiff, W. J. Muller, Induction of mammary tumors by expression of polyomavirus middle T oncogene: A transgenic mouse model for metastatic disease. Mol. Cell. Biol. 12, 954–961 (1992).

10.1016/j.immuni.2007.04.017

10.1007/978-1-61737-979-6_10

10.1084/jem.20061852

10.4049/jimmunol.1202752

10.1038/icb.2014.26

10.1038/nri2206

10.1126/science.1206954

10.1074/jbc.M116.757773

10.1038/nmeth872

10.1002/eji.201141700

10.1084/jem.20020732

10.1158/0008-5472.CAN-04-4262

10.1200/JCO.2014.58.3708

10.1200/JCO.2014.58.1041

10.1634/theoncologist.2015-0509

10.1097/CMR.0000000000000273

10.2174/1574886311207040289

10.1158/1078-0432.CCR-12-0781

10.1158/1078-0432.CCR-13-1923

10.1172/JCI64859

10.1084/jem.20071341

10.1186/2051-1426-3-S2-P113

10.1002/j.1460-2075.1990.tb08211.x

10.1038/nri1371

10.1158/2326-6066.CIR-14-0187

10.1158/1078-0432.CCR-12-0990

10.4049/jimmunol.176.2.974

10.1182/blood-2002-03-0991

10.1002/eji.200636957

10.1084/jem.20120532

10.1158/0008-5472.CAN-07-6484

10.1002/ijc.24435

10.1182/blood-2004-07-2959

10.1023/A:1018778403001

10.1002/(SICI)1097-4652(200002)182:2<150::AID-JCP3>3.0.CO;2-E

J. E. Maglione, D. Moghanaki, L. J. T. Young, C. K. Manner, L. G. Ellies, S. O. Joseph, B. Nicholson, R. D. Cardiff, C. L. MacLeod, Transgenic Polyoma middle-T mice model premalignant mammary disease. Cancer Res. 61, 8298–8305 (2001).