Epstein–Barr virus expression in plasma cell neoplasms and its association with plasmablastic morphologic features
Tóm tắt
Plasma cell neoplasms include plasma cell myeloma, plasmacytoma, primary amyloidosis, and light and heavy chain deposition diseases. Epstein–Barr virus (EBV) expression has rarely been reported to be associated with plasma cell neoplasms except for patients with a previous history of transplantation or severe immunodeficiency. In contrast, EBV expression has been reported in the majority of plasmablastic lymphoma, a subtype of diffuse large B cell lymphoma. We report three cases with a plasma cell neoplasm (two plasma cell myelomas and one case of plasmacytoma), where EBV infection was diffusely detected by in situ hybridization. All three patients were under the age of 40 years, and one of the three patients was an HIV-positive individual while the other two patients did not have any identifiable source for immunosuppression. All three cases showed multifocal plasmablastic features, which is concordant with the most recent reports about the possible association of EBV expression with plasmablastic morphologic features and increased proliferative activity.
Tài liệu tham khảo
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