Epidemiology of uveitis in a Western urban multiethnic population. The challenge of globalization

Acta Ophthalmologica - Tập 93 Số 6 - Trang 561-567 - 2015
Víctor Llorenç1, Marina Mesquida1, Maite Sáinz de la Maza1, Johannes Keller1, Blanca Molins2, Gerard Espinosa3, M.V. Hernández4, Julián González-Martín5, Alfredo Adán1
1Clínic Institute of Ophthalmology (ICOF) Hospital Clinic of Barcelona Barcelona Spain
2Institut de Recerca Biomèdica August Pi i Sunyer (IDIBAPS) Hospital Clínic of Barcelona Barcelona Spain
3Department of Autoimmune & Systemic Diseases (ICM) Hospital Clinic of Barcelona Barcelona Spain
4Rheumatology Department, Hospital Clinic of Barcelona, Barcelona, Spain
5Department of Clinical Microbiology (CDB-CRESIB)., Hospital Clinic of Barcelona, Barcelona, Spain

Tóm tắt

AbstractPurposeTo report the anatomical pattern and etiological spectrum of uveitis in an urban multi‐ethnic population from Barcelona, Spain. General and specific epidemiological data for the most prevalent aetiologies are also calculated.MethodsA cross‐sectional study of consecutive uveitis cases was performed between 1 January 2009 and 31 December 2012. Exogenous endophthalmitis, surgery‐related, post‐traumatic and toxic uveitis along with masquerade syndromes were excluded. Anatomical (Standard Uveitis Nomenclature criteria) and aetiological patterns (by tailored tests), age, sex, geographical origin and laterality were analysed. Mean incidence and prevalence were calculated for a mid‐period reference population.ResultsFrom 1022 patients included, 52% were anterior uveitis (AU), 23% posterior, 15% panuveitis and 9% intermediate uveitis. Aetiologically, 26% were unclassifiable, 29% infectious, 25% associated with systemic immune diseases, and 20% corresponded to ocular‐specific syndromes. Among classified causes, herpesvirus (12%), toxoplasma (7%), Behçet's disease (BD) (5%), HLA‐B27‐isolated AU (5%), ankylosing spondylitis (5%), tuberculosis‐related uveitis (TRU) (5%), birdshot chorioretinopathy (3%) and sarcoidosis (3%) were the most frequent. Non‐Spanish origin was recorded in 22%, with 47% of Vogt‐Koyanagi‐Harada and 36% of toxoplasma cases coming from South America, 10% of BD and 11% of TRU from Africa and 24% of TRU cases from Asia. A mean annual incidence of 51.91 cases/100 000 inhabitants was found for the referral population.ConclusionIn our referral area, 74% of the uveitis cases can be correctly classified. A large myriad of uveitis aetiologies with a strong geographical origin burden are found in Western urban multi‐ethnic populations.

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Acta Ophthalmologica

Tập 93 Số 6

561-567

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