Epidemiology of childhood acute myeloid leukemia

Pediatric Blood and Cancer - Tập 60 Số 5 - Trang 728-733 - 2013
Susan E. Puumala1,2, Julie A. Ross3,4, Richard Aplenc5, Logan G. Spector3,4
1Center for Health Outcomes and Prevention Research, Sanford Research, Sioux Falls, South Dakota
2Department of Pediatrics, Sanford School of Medicine, University of South Dakota, Sioux Falls, South Dakota
3Division of Pediatric Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota
4University of Minnesota Masonic Cancer Center, Minneapolis, Minnesota
5Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

Tóm tắt

AbstractAlthough leukemia is the most common childhood cancer diagnosis, the subtype, acute myeloid leukemia (AML), is less common and fewer etiologic studies exist. This review summarizes the major risk factors for AML. We searched the literature using PubMed for articles on childhood AML and reviewed 180 articles. While few risk factors are definitive, we identified several with consistent evidence of a possible effect. Thorough analysis of genetic and epigenetic factors is missing from this literature and methodological issues are unresolved. Future studies should more closely examine causal mechanisms, improve exposure measurement, and include analysis using genetic and epigenetic factors. Pediatr Blood Cancer 2013; 60: 728–733. © 2013 Wiley Periodicals, Inc.

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