Epidemiology of bone tumours in children and young adults

Pediatric Blood and Cancer - Tập 53 Số 6 - Trang 941-952 - 2009
Rachel Eyre1, Richard Feltbower2, Emmanuel Mubwandarikwa1, Tim Eden3, Richard McNally4,5
1Institute of Health & Society, Newcastle University, Newcastle Upon Tyne, England, United Kingdom.
2Paediatric Epidemiology Group, University of Leeds, Leeds, England, United Kingdom
3Academic Unit of Paediatric and Adolescent Oncology, c/o Teenage Cancer Trust Young Oncology Unit, Christie Hospital, University of Manchester, Manchester, England, United Kingdom
4Institute of Health and Society, Newcastle University, Newcastle upon Tyne, England, United Kingdom
5Sir James Spence Institute, Newcastle University, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NE1 4LP, England, United Kingdom.

Tóm tắt

AbstractAlthough the epidemiology of malignant bone tumours in children and young adults has been explored, no definitive causation of any specific tumour has yet been identified. We performed a literature review (1970–2008) to find all papers covering possible aetiological factors involved in the development of bone tumours in children and young adults. Several associations have been reported with some consistency: the presence of hernias and Ewing sarcoma; high fluoride exposure and osteosarcoma; and parental farming and residence on a farm, younger age at puberty and family history of cancer for all bone tumours, especially osteosarcoma. Clearly further research is needed to confirm or refute these putative risk factors. It is likely that studies of gene–environment interactions may prove to be the most fruitful of future research. Pediatr Blood Cancer 2009;53:941–952. © 2009 Wiley‐Liss, Inc.

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