Epidemiology of COVID-19 Among Children in China

American Academy of Pediatrics (AAP) - Tập 145 Số 6 - 2020
Yuanyuan Dong1,2,3, Xi Mo2,3, Yabin Hu3, Xin Qi4, Fan Jiang3, Zhongyi Jiang1,3, Shilu Tong5,6,3
1Child Health Advocacy Institute, China Hospital Development Institute, Shanghai Jiao Tong University, Shanghai, China
2Contributed equally as co-first authors
3Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
4Schools of Public Health and Medicine, Xian Jiaotong University, Xian, China;
5Institute of Environment and Population Health, School of Public Health, Anhui Medical University, Hefei, China; and
6School of Public Health, Nanjing Medical University, Nanjing, China

Tóm tắt

OBJECTIVE: To identify the epidemiological characteristics and transmission patterns of pediatric patients with the 2019 novel coronavirus disease (COVID-19) in China. METHODS: Nationwide case series of 2135 pediatric patients with COVID-19 reported to the Chinese Center for Disease Control and Prevention from January 16, 2020, to February 8, 2020, were included. The epidemic curves were constructed by key dates of disease onset and case diagnosis. Onset-to-diagnosis curves were constructed by fitting a log-normal distribution to data on both onset and diagnosis dates. RESULTS: There were 728 (34.1%) laboratory-confirmed cases and 1407 (65.9%) suspected cases. The median age of all patients was 7 years (interquartile range: 2–13 years), and 1208 case patients (56.6%) were boys. More than 90% of all patients had asymptomatic, mild, or moderate cases. The median time from illness onset to diagnoses was 2 days (range: 0–42 days). There was a rapid increase of disease at the early stage of the epidemic, and then there was a gradual and steady decrease. The disease rapidly spread from Hubei province to surrounding provinces over time. More children were infected in Hubei province than any other province. CONCLUSIONS: Children of all ages appeared susceptible to COVID-19, and there was no significant sex difference. Although clinical manifestations of children’s COVID-19 cases were generally less severe than those of adult patients, young children, particularly infants, were vulnerable to infection. The distribution of children’s COVID-19 cases varied with time and space, and most of the cases were concentrated in Hubei province and surrounding areas. Furthermore, this study provides strong evidence of human-to-human transmission.

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American Academy of Pediatrics (AAP)

Tập 145 Số 6

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