Environmental and heritable causes of cancer among 9.6 million individuals in the Swedish family‐cancer database

International Journal of Cancer - Tập 99 Số 2 - Trang 260-266 - 2002
Kamila Czene1, Paul Lichtenstein2, Kari Hemminki3
1Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
2Karolinska Institutet
3Cancer Risk Factors and Prevention

Tóm tắt

Abstract

The genetic and environmental components in 15 common cancers were estimated using the nationwide Swedish Family‐Cancer Database. Tetrachoric correlations were used to describe similarity in cancer liability among family members. Structural equation modeling was used to derive estimates of the importance of genetic and environmental effects. Statistically significant estimates of proportion of cancer susceptibility, accounted for by genetic effects, were obtained for all studied cancers except for leukemia. The estimate was highest in thyroid cancer (53%), followed by tumors at endocrine glands (28%), testis (25%), breast (25%), cervix (22%), melanoma (21%), colon (13%), nervous system (12%), rectum (12%), non‐Hodgkin lymphoma (10%), lung (8%), kidney (8%), urinary bladder (7%), stomach (1%) and leukemia (1%). The estimates of shared environmental effects ranged from 0% (cervix) to 15% (stomach). The childhood shared environmental effects were most important in testicular cancer (17%), stomach cancer (13%) and cervix in situ (13%). Our results indicate that environment has a principal causative role in cancer at all studied sites except for thyroid. The relatively large effect of heritability in cancer at some sites, on the other hand, indicates that even though susceptibility genes have been described at many cancer sites, they are likely to explain only part of the genetic effects. © 2002 Wiley‐Liss, Inc.

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International Journal of Cancer

Tập 99 Số 2

260-266

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