Enlargement of Nanoemulsion Region in Pseudo‐ternary Mixing Diagrams for a Drug Delivery System

Journal of Surfactants and Detergents - Tập 17 Số 1 - Trang 49-58 - 2014
Ziheng Wang1, Rajinder Pal2,1,3
1Department of Chemical Engineering, University of Waterloo, N2L 3G1 Waterloo, ON, Canada
2+1-5198884567
3[email protected]

Tóm tắt

AbstractThe purpose of this research was to develop the pseudo‐ternary mixing diagrams for a potential drug delivery system consisting of vitamin E (potential drug) + soybean oil + surfactant + co‐surfactant (anhydrous glycerol) + water. The potential drug (vitamin E) was loaded in the oil phase. The effects of different surfactants (pure and mixed) on the mixing diagrams, especially on the nanoemulsion region, were investigated. The influence of the drug loading level on the mixing diagrams was also determined. The surfactants studied were polyethoxylated (20) sorbitan monolaurate, polyethoxylated (20) sorbitan monooleate, polyethoxylated (35) castor oil and their mixtures. The size (area) of the nanoemulsion region of the mixing diagrams was found to be dependent on the type of surfactant used and the loading level of the drug (vitamin E).

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Thông tin xuất bản

Journal of Surfactants and Detergents

Tập 17 Số 1

49-58

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