Enhanced host perforant path innervation of neonatal dentate tissue after grafting to axon sparing, ibotenic acid lesions in adult rats
Tóm tắt
This study examines to which extent developing dentate granule cells grafted into excitotoxic lesions of the adult rat fascia dentata can be appropriately innervated by the host brain. The lesions were induced by focal injections of ibotenic acid (IA) and resulted in localized dentate and hippocampal neuronal cell death, but sparing of the afferent connections, now deprived of their targets. One week later pieces of fascia dentata from new-born rats were grafted into the lesions. After 6 weeks to 9 months the recipient brains were processed and analyzed by cell stain, histochemistry, immunohistochemistry, anterograde nerve fiber degeneration methods, and electron microscopy. Dentate grafts survived well in the lesion area and became organo-typically organized. They contained the normal nerve cell types of the fascia dentata and hilus (CA4), including the peptidergic somatostatin-, cholecystokinin- and enkephalin-reactive ones. The grafts were innervated by AChE-positive, cholinergic fibers from the host septum, and perforant path fibers from the host entorhinal area. The presence of the latter were demonstrated by Timm staining and light and electron microscopy of anterograde axonal degeneration. When the extent and density of the host perforant path innervation was examined and mapped at the electron microscopical level the grafts in the IA-lesions were found to receive a more extensive and denser host innervation than grafts placed in the normal fascia dentata of adult rats without a preceding axon-sparing ibotenic acid lesion. In this way the results demonstrate that certain lesion types can enhance the innervation of intracerebral grafts by already mature neural pathways of the point-to-point type.
Tài liệu tham khảo
citation_journal_title=Exp Brain Res; citation_title=The effects of intrahippocampal ibotenic acid and their blockade by (-) 2- amino-7-phosphonoheptanoic acid: morphological and electroencephalographical analysis; citation_author=C Aldinio, ED French, R Schwarcz; citation_volume=51; citation_publication_date=1983; citation_pages=36-44; citation_id=CR1
citation_journal_title=J Comp Neurol; citation_title=Neural tissue transplants rescue axotomized rubrospinal cells from retrograde death; citation_author=BS Bregman, PJ Reier; citation_volume=244; citation_publication_date=1986; citation_pages=86-95; citation_id=CR2
citation_journal_title=Ann NY Acad Sci; citation_title=Progress in facilitating the recovery of function after central nervous system trauma; citation_author=CW Cotman, M Nieto-Sampedro; citation_volume=457; citation_publication_date=1985; citation_pages=83-104; citation_id=CR3
citation_title=The use of excitatory amino acids as selective neurotoxins; citation_inbook_title=Handbook of chemical neuroanatomy, Vol 1. Methods in chemical neuroanatomy; citation_publication_date=1983; citation_pages=508-527; citation_id=CR4; citation_author=JT Coyle; citation_author=R Schwarcz; citation_publisher=Elsevier
Devor M, Schneider GE (1975) Neuroanatomical plasticity: the principle of conservation of total axonal arborization. In: Vital-Durand F, Hannerod M (eds) Aspects of neural plasticity/plasticité nerveuse. INSERM 43: 191–200
citation_journal_title=J Comp Neurol; citation_title=Accelerated rates of synaptogenesis by “sprouting” afferents in the immature hippocampal formation; citation_author=C Gall, R McWilliams, G Lynch; citation_volume=193; citation_publication_date=1980; citation_pages=1047-1061; citation_id=CR6
citation_journal_title=Z Zellforsch; citation_title=Distribution of acetyl cholinesterase in the hippocampal region of the guinea pig. I. Entorhinal area, parasubiculum, and presubiculum; citation_author=FA Geneser-Jensen, TW Blackstad; citation_volume=114; citation_publication_date=1971; citation_pages=460-481; citation_id=CR7
citation_journal_title=Adv Anat Embryol Cell Biol; citation_title=Heavy metals in the brain. A light microscope study of the rat with Timm's sulphide silver method: methodological considerations and cytological and regional staining patterns; citation_author=F-MS Haug; citation_volume=47; citation_publication_date=1973; citation_pages=1-71; citation_id=CR8
citation_journal_title=Brain Res; citation_title=Hippocampal neurotrophic factor: characterization and response to denervation; citation_author=AM Heacock, AR Schonfeld, R Katzman; citation_volume=363; citation_publication_date=1986; citation_pages=299-306; citation_id=CR9
citation_journal_title=Stain Technol; citation_title=Fink-Heimer silver impregnation of degenerating axons and terminals in mounted cryostat sections of fresh and fixed brains; citation_author=A Hjorth-Simonsen; citation_volume=45; citation_publication_date=1970; citation_pages=199-204; citation_id=CR10
citation_journal_title=Neuroscience; citation_title=Neural grafting in a rat model of Huntington's disease: progressive neurochemical changes after neostriatal ibotenate lesions and striatal tissue grafting; citation_author=O Isacson, P Brundin, FH Gage, A Björklund; citation_volume=16; citation_publication_date=1985; citation_pages=799-817; citation_id=CR11
citation_journal_title=Nature; citation_title=Functional neuronal replacement by grafted striatal neurones in the ibotenic acid lesioned rat striatum; citation_author=O Isacson, P Brundin, PAT Kelly, FH Gage, A Björklund; citation_volume=311; citation_publication_date=1984; citation_pages=458-460; citation_id=CR12
citation_journal_title=Exp Neurol; citation_title=Transplants of purified astrocytes promote behavioral recovery after frontal cortex ablation; citation_author=JP Kesslak, M Nieto-Sampedro, J Globus, CW Cotman; citation_volume=92; citation_publication_date=1986; citation_pages=377-390; citation_id=CR13
citation_title=Neuronal degeneration after intracerebral injections of excitotoxins: a histological analysis of kainic acid, ibotenic acid and quinolinic acid lesions in the rat brain; citation_inbook_title=Excitotoxins; citation_publication_date=1983; citation_pages=99-111; citation_id=CR14; citation_author=C Köhler; citation_publisher=Macmillan Press
citation_journal_title=Neurosci Lett; citation_title=Intrahippocampal injections of ibotenic acid provide histological evidence for a neurotoxic mechanism different from kainic acid; citation_author=C Köhler, R Schwarcz, K Fuxe; citation_volume=15; citation_publication_date=1979; citation_pages=223-228; citation_id=CR15
citation_journal_title=Brain Res; citation_title=Astrocyte cultures from adult rat brain. Derivation, characterization and neurotrophic properties of pure astroglial cells from corpus callosum; citation_author=RM Lindsay, PC Barber, MRC Sherwood, J Zimmer, G Raisman; citation_volume=243; citation_publication_date=1982; citation_pages=329-343; citation_id=CR16
citation_journal_title=Nature; citation_title=Anatomical distributions of four pharmacologically distinct 3H-L-glutamate binding sites; citation_author=DT Monaghan, VR Holets, DW Toy, CW Cotman; citation_volume=306; citation_publication_date=1983; citation_pages=176-179; citation_id=CR17
citation_journal_title=J Comp Neurol; citation_title=Fate of the hippocampal mossy fiber projection after destruction of its postsynaptic targets with intraventricular kainic acid; citation_author=JV Nadler, BW Perry, C Gentry, CW Cotman; citation_volume=196; citation_publication_date=1981; citation_pages=549-569; citation_id=CR18
citation_journal_title=Proc Natl Acad Sci USA; citation_title=The survival of brain transplants is enhanced by extracts from injured brain; citation_author=M Nieto-Sampedro, SR Whittemore, DL Needels, J Larson, CW Cotman; citation_volume=81; citation_publication_date=1984; citation_pages=6250-6254; citation_id=CR19
citation_journal_title=Neuroscience; citation_title=Mossy fibre projections into and out of hippocampal transplants; citation_author=G Raisman, FF Ebner; citation_volume=9; citation_publication_date=1983; citation_pages=783-801; citation_id=CR20
citation_journal_title=Exp Brain Res; citation_title=Ibotenic acid-induced neuronal degeneration: a morphological and neurochemical study; citation_author=R Schwarcz, T Hökfelt, K Fuxe, G Jonsson, M Goldstein, L Terenius; citation_volume=37; citation_publication_date=1979; citation_pages=199-216; citation_id=CR21
citation_journal_title=Proc Natl Acad Sci USA; citation_title=Growth and differentation of cerebellar suspensions transplanted into the adult cerebellum of mice with heredodegenerative ataxia; citation_author=C Sotelo, RM Alvarado-Mallart; citation_volume=83; citation_publication_date=1986; citation_pages=1135-1139; citation_id=CR22
citation_title=Immunocytochemistry; citation_publication_date=1979; citation_id=CR23; citation_author=LA Sternberger; citation_publisher=Wiley
citation_journal_title=Nature; citation_title=Brain grafts can restore irradiation-damaged neuronal connections in newborn rats; citation_author=N Sunde, S Laurberg, I Zimmer; citation_volume=310; citation_publication_date=1984; citation_pages=51-53; citation_id=CR24
citation_journal_title=Acta Neurol Scand; citation_title=Transplantation of central nervous tissue; citation_author=N Sunde, J Zimmer; citation_volume=63; citation_publication_date=1981; citation_pages=323-335; citation_id=CR25
citation_journal_title=Dev Brain Res; citation_title=Cellular, histochemical and connective organization of the hippocampus and fascia dentata transplanted to different regions of immature and adult rat brains; citation_author=NA Sunde, J Zimmer; citation_volume=8; citation_publication_date=1983; citation_pages=165-191; citation_id=CR26
citation_title=Repair of neonatal irradiation-induced damage to the rat fascia dentata: effects of delayed intracerebral transplantation; citation_inbook_title=Neural grafting in the mammalian CNS; citation_publication_date=1985; citation_pages=301-308; citation_id=CR27; citation_author=N Sunde; citation_author=J Zimmer; citation_author=S Laurberg; citation_publisher=Elsevier
citation_journal_title=J Comp Neurol; citation_title=Intracephalic transplants of freeze-stored rat hippocampal tissue; citation_author=T Sørensen, S Jensen, A Møller, J Zimmer; citation_volume=252; citation_publication_date=1986; citation_pages=468-482; citation_id=CR28
citation_journal_title=Brain Res; citation_title=Nerve connections between mouse and rat hippocampal brain tissue: ultrastructural observations after intracerebral xenografting; citation_author=T Sørensen, B Finsen, J Zimmer; citation_volume=413; citation_publication_date=1987; citation_pages=392-397; citation_id=CR29
citation_journal_title=Dtsch Z Gerichtl Med; citation_title=Zur Histochemie der Schwermetalle: das SulfidSilber-Verfahren; citation_author=F Timm; citation_volume=46; citation_publication_date=1958; citation_pages=706-711; citation_id=CR30
Tønder N, Zimmer J, Sørensen T, Johansen FF, Jørgensen MB, Diemer NH (1988) Neural transplantation to ischemic lesions in the adult rat hippocampus. Exp Brain Res (in press)
citation_journal_title=Ann Rev Pharmacol Toxicol; citation_title=Excitatory amino acid transmitters; citation_author=JC Watkins, RH Evans; citation_volume=21; citation_publication_date=1981; citation_pages=165-204; citation_id=CR32
citation_journal_title=Dev Brain Res; citation_title=Neuronotrophic factors for mammalian brain neurons: injury induction in neonatal, adult and aged rat brain; citation_author=SR Whittemore, M Nieto-Sampedro, DL Needels, CW Cotman; citation_volume=20; citation_publication_date=1985; citation_pages=169-178; citation_id=CR33
citation_journal_title=Brain Res; citation_title=Changes in the Timm sulfide silver staining pattern of the rat hippocampus and fascia dentata following early postnatal deafferentation; citation_author=J Zimmer; citation_volume=64; citation_publication_date=1973; citation_pages=313-326; citation_id=CR34
citation_journal_title=Prog Brain Res; citation_title=Development of the hippocampus and fascia dentata: morphological and histochemical aspects; citation_author=J Zimmer; citation_volume=48; citation_publication_date=1978; citation_pages=171-189; citation_id=CR35
citation_title=Hippocampal transplants: synaptic organization, their use in repair of neuronal circuits and mouse to rat xenografting; citation_inbook_title=Nato ASI, Series H, Vol 2. Glialneuronal communication in development and regeneration; citation_publication_date=1987; citation_pages=547-564; citation_id=CR36; citation_author=J Zimmer; citation_author=B Finsen; citation_author=T Sørensen; citation_author=N Sunde; citation_publisher=Springer
citation_journal_title=J Comp Neurol; citation_title=Cellular and connective organization of slice cultures of the rat hippocampus and fascia dentata; citation_author=J Zimmer, BH Gähwiler; citation_volume=228; citation_publication_date=1984; citation_pages=432-446; citation_id=CR37
citation_journal_title=J Comp Neurol; citation_title=Growth of hippocampal mossy fibers: a lesion and coculture study of organotypic slice cultures; citation_author=J Zimmer, BH Gähwiler; citation_volume=264; citation_publication_date=1987; citation_pages=1-13; citation_id=CR38
citation_journal_title=Exp Brain Res; citation_title=Non-cholinergic afferents determine the distribution of the cholinergic septohippocampal projection: a study of the AChE staining pattern in the rat fascia dentata and hippocampus after lesions, X-irradiation, and intracerebral grafting; citation_author=J Zimmer, S Laurberg, N Sunde; citation_volume=64; citation_publication_date=1986; citation_pages=158-168; citation_id=CR39
citation_journal_title=J Comp Neurol; citation_title=Neuropeptides and astroglia in intracerebral hippocampal transplants: an immunohistochemical study in the rat; citation_author=J Zimmer, N Sunde; citation_volume=227; citation_publication_date=1984; citation_pages=331-347; citation_id=CR40
citation_title=Reorganization and restoration of central nervous connections after injury: a lesion and transplant study of the rat hippocampus; citation_inbook_title=Brain plasticity, learning, and memory; citation_publication_date=1985; citation_pages=505-518; citation_id=CR41; citation_author=J Zimmer; citation_author=N Sunde; citation_author=T Sørensen; citation_publisher=Plenum Publishing Corporation