Enantioselective Catalysis, XIII. Preparative and Structural Chemistry of Chiral 3‐(Diphenylphosphanyl)‐pyrrolidiens and Their Palladium(II) Complexes

Wiley - Tập 130 Số 3 - Trang 385-398 - 1997
Ulrich Nagel1, Hans Günter Nedden1
1Institut für Anorganische Chemie, Universität Tübingen, Auf der Morgenstelle 18, D‐72076 Tübingen, Germany Fax: (internat.)+49(0)7071/29‐5306 E‐mail: Ulrich.Nagel@Uni‐Tuebingen.de

Tóm tắt

AbstractThe preparation of both enantiomers of 3‐diphenylphosphanulpyrrolidiine (2) and several N‐substituted derivatives together with two PdIi complexes of this ligand is reported. Form L‐malic acid and L‐hydroxyproline both enantiomers of 3‐hydroxypyrrolidine are prepared without any problems due to epimerization. KPPh2 in the presence of LiCl is shown to be the most effective reagent for the synthesis of 2. The reported X‐ray structure determination sof Pdl2 complexes show a rather rigid bicyclic hetero‐norbornane skeleton. The flexibility of the other parts of the molecules is obvious in several polymorphs revealed by this method. This polymorphism is additionally investigated by a 31P‐CP‐MAS study. From solution 1‐, 13C‐ and 31P‐NMR studies it is concluded that the bicyclic hetero‐norbornane skeleton is retained in solution.

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Wiley

Tập 130 Số 3

385-398

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