Emerging microRNA Therapeutic Approaches for Cystic Fibrosis

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Lutful Kabir, 2017, microRNA-145 antagonism reverses TGF-beta inhibition of F508del CFTR correction in airway epithelia., Am. J. Respir. Crit. Care Med., 197, 632, 10.1164/rccm.201704-0732OC

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Megiorni, 2013, Elevated levels of miR-145 correlate with SMAD3 down-regulation in Cystic Fibrosis patients., J. Cyst. Fibros, 12, 797, 10.1016/j.jcf.2013.03.007

Megiorni, 2011, Synergistic post-transcriptional regulation of the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) by miR-101 and miR-494 specific binding., PLoS One, 6, 10.1371/journal.pone.0026601

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Oglesby, 2013, Regulation of cystic fibrosis transmembrane conductance regulator by MicroRNA-145, -223, and -494 is altered in DeltaF508 cystic fibrosis airway epithelium., J. Immunol., 190, 3354, 10.4049/jimmunol.1202960

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Sonneville, 2015, New insights about miRNAs in cystic fibrosis., Am. J. Pathol., 185, 897, 10.1016/j.ajpath.2014.12.022

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Tsuchiya, 2016, RPTOR, a novel target of miR-155, elicits a fibrotic phenotype of cystic fibrosis lung epithelium by upregulating CTGF., RNA Biol., 13, 837, 10.1080/15476286.2016.1197484

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Zhang, 2015, Pharmacological modulation of the AKT/microRNA-199a-5p/CAV1 pathway ameliorates cystic fibrosis lung hyper-inflammation., Nat. Commun., 6, 10.1038/ncomms7221

Zhong, 2011, MiR-146a negatively regulates neutrophil elastase-induced MUC5AC secretion from 16HBE human bronchial epithelial cells., Mol. Cell. Biochem., 358, 249, 10.1007/s11010-011-0975-2