Eltrombopag và Dexamethasone liều cao như liệu pháp đầu tay điều trị bệnh tiểu cầu miễn dịch mới được chẩn đoán ở người lớn

Blood - Tập 123 - Trang 3906-3908 - 2014
David Gómez-Almaguer1, Miguel A. Herrera-Rojas1, José C. Jaime-Pérez1, Andrés Gómez-De León1, Olga G. Cantú-Rodríguez1, César H. Gutiérrez-Aguirre1, Luz Tarín-Arzaga1, Jesús Hernández-Reyes2,3, Guillermo J. Ruiz-Arguelles3
1Hematology Service, Hospital Universitario “Dr José Eleuterio González,” Universidad Autónoma de Nuevo León, Monterrey, México;
2Universidad del Valle de México, Villahermosa, México; and
3Centro de Hematología y Medicina Interna de Puebla, Clínica Ruiz, Universidad de las Américas Puebla, Universidad Popular Autónoma del Estado de Puebla, Puebla, México

Tóm tắt

Điểm chính Eltrombopag/dexamethasone là một sự kết hợp an toàn và hiệu quả trong việc điều trị bệnh nhân ITP mới được chẩn đoán. Phương pháp điều trị này có thể hữu ích trong việc đạt được các phản ứng lâu dài mà không cần thêm sự ức chế miễn dịch ở một số bệnh nhân.

Từ khóa


Tài liệu tham khảo

Toltl, 2011, Pathophysiology and management of chronic immune thrombocytopenia: focusing on what matters., Br J Haematol, 152, 52, 10.1111/j.1365-2141.2010.08412.x Rodeghiero, 2009, Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group., Blood, 113, 2386, 10.1182/blood-2008-07-162503 Provan, 2010, International consensus report on the investigation and management of primary immune thrombocytopenia., Blood, 115, 168, 10.1182/blood-2009-06-225565 Cheng, 2003, Initial treatment of immune thrombocytopenic purpura with high-dose dexamethasone., N Engl J Med, 349, 831, 10.1056/NEJMoa030254 Matzdorff, 2011, Advances in ITP—therapy and quality of life—a patient survey., PLoS ONE, 6, e27350, 10.1371/journal.pone.0027350 Kuter, 2012, Health-related quality of life in nonsplenectomized immune thrombocytopenia patients receiving romiplostim or medical standard of care., Am J Hematol, 87, 558, 10.1002/ajh.23163 Zaja, 2010, Dexamethasone plus rituximab yields higher sustained response rates than dexamethasone monotherapy in adults with primary immune thrombocytopenia., Blood, 115, 2755, 10.1182/blood-2009-07-229815 Li, 2011, Low-dose rituximab combined with short-term glucocorticoids up-regulates Treg cell levels in patients with immune thrombocytopenia., Int J Hematol, 93, 91, 10.1007/s12185-010-0753-z Gómez-Almaguer, 2013, High response rate to low-dose rituximab plus high-dose dexamethasone as frontline therapy in adult patients with primary immune thrombocytopenia., Eur J Haematol, 90, 494, 10.1111/ejh.12102 Gudbrandsdottir, 2013, Rituximab and dexamethasone vs dexamethasone monotherapy in newly diagnosed patients with primary immune thrombocytopenia., Blood, 121, 1976, 10.1182/blood-2012-09-455691 Cheng, 2011, Eltrombopag for management of chronic immune thrombocytopenia (RAISE): a 6-month, randomised, phase 3 study., Lancet, 377, 393, 10.1016/S0140-6736(10)60959-2 Saleh, 2013, Safety and efficacy of eltrombopag for treatment of chronic immune thrombocytopenia: results of the long-term, open-label EXTEND study., Blood, 121, 537, 10.1182/blood-2012-04-425512 Bussel, 2013, Repeated short-term use of eltrombopag in patients with chronic immune thrombocytopenia (ITP)., Br J Haematol, 160, 538, 10.1111/bjh.12169 Neunert, 2011, The American Society of Hematology 2011 evidence-based practice guideline for immune thrombocytopenia., Blood, 117, 4190, 10.1182/blood-2010-08-302984 Rodeghiero, 2013, Standardization of bleeding assessment in immune thrombocytopenia: report from the International Working Group., Blood, 121, 2596, 10.1182/blood-2012-07-442392 Kashiwagi, 2013, Pathophysiology and management of primary immune thrombocytopenia., Int J Hematol, 98, 24, 10.1007/s12185-013-1370-4 Bao, 2010, Improved regulatory T-cell activity in patients with chronic immune thrombocytopenia treated with thrombopoietic agents., Blood, 116, 4639, 10.1182/blood-2010-04-281717 Ghadaki, 2013, Sustained remissions of immune thrombocytopenia associated with the use of thrombopoietin receptor agonists., Transfusion, 53, 2807, 10.1111/trf.12139 Rao, 2013, ITP: hematology’s Cosette from Les Misérables., Blood, 121, 1928, 10.1182/blood-2013-01-477729 Kühne, 2011, Newly diagnosed immune thrombocytopenia in children and adults: a comparative prospective observational registry of the Intercontinental Cooperative Immune Thrombocytopenia Study Group., Haematologica, 96, 1831, 10.3324/haematol.2011.050799