Elevated levels of body mass index and waist circumference, but not high variability, are associated with an increased risk of atrial fibrillation

BMC Medicine - Tập 20 - Trang 1-9 - 2022
Maoxiang Zhao1, Lulu Song2, Qianqian Zhao1, Yating Chen1, Bin Li1, Zhonghui Xie1, Zihao Fu1, Nan Zhang1, Xiaowei Cheng1, Xiaoqian Li3, Miao Wang4, Shouling Wu5, Hao Xue6, Yang Li1
1Department of Cardiology, The First Medical Center, Chinese People’s Liberation Army Hospital, Medical School of Chinese People’s Liberation Army, Beijing, China
2Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
3Department of Cardiology, Fujian Medical University, Fuzhou, China
4School of Medicine, Nankai University, Tianjin, China
5Department of Cardiology, Kailuan Hospital, Tangshan, China
6Department of Cardiology, the Sixth Medical Center, Chinese People’s Liberation Army Hospital, Medical School of Chinese People’s Liberation Army, Beijing, China

Tóm tắt

Although obesity has been associated with risk of atrial fibrillation (AF), the associations of variability of obesity measures with AF risk are uncertain, and longitudinal studies among Chinese population are still lacking. We aimed to evaluate the impacts of obesity and variability of body mass index (BMI) and waist circumference (WC) on the risk of atrial fibrillation (AF) in a large Chinese cohort study. A total of 44,135 participants of the Kailuan Study who were free of cancer and cardiovascular disease and underwent three consecutive surveys from 2006 to 2010 were followed for incident AF until 2020. Average BMI and WC over time and variability were calculated. Cox proportional hazards regression models were used to assess hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations of obesity and variability in BMI and WC with AF risk. During a mean follow-up of 9.68 years, there were 410 cases of incident AF. In multivariable-adjusted models, compared with normal BMI/WC, individuals with general obesity and abdominal obesity had increased risk of AF, with corresponding HRs of 1.73 (95% CI: 1.31–2.30) and 1.38 (95% CI: 1.11–1.60), respectively. The short-term elevation in AF risk persisted for the obese even after adjustment for updated biologic intermediaries and weight. Variability in BMI and WC were not associated with the risk of AF. The restricted cubic spline models indicated significant linear relationships between levels of WC and BMI and risk of AF. Elevated levels of BMI and WC were associated with an increased risk of AF, whereas variability in BMI and WC were not. Therefore, achieving optimal levels of BMI and WC could be valuable in AF prevention.

Tài liệu tham khảo

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