Tăng mức độ của thụ thể hòa tan cho các sản phẩm cuối glycation tiên tiến liên quan đến bệnh teo cơ: một nghiên cứu quan sát

BMC Geriatrics - Tập 21 - Trang 1-9 - 2021
Shou-En Wu1,2, Yi-Lin Chiu3, Tung-Wei Kao1,2, Wei-Liang Chen1,2,3
1Department of General Medicine, Tri-Service General Hospital, and School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China
2Department of Family and Community Medicine, Division of Geriatric Medicine, Tri-Service General Hospital, and School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China
3Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan, Republic of China

Tóm tắt

Thụ thể hòa tan cho các sản phẩm cuối glycation tiên tiến (sRAGE) đã được đề xuất như một dấu hiệu cho mức độ nghiêm trọng của bệnh, nhưng vai trò của nó trong bệnh teo cơ, một tình trạng mất mát cơ bắp và chức năng tiến triển theo tuổi tác, vẫn còn mơ hồ. Nghiên cứu này khảo sát mối liên hệ giữa sRAGE và bệnh teo cơ. Tổng cộng có 314 người cao tuổi sống trong cộng đồng, đã thực hiện kiểm tra sức khỏe tại Bệnh viện Đặc nhiệm từ năm 2017 đến 2019, đã trải qua phân tích protein bằng phương pháp xét nghiệm miễn dịch liên kết enzyme. Mối quan hệ với bệnh teo cơ và thông tin chi tiết của nó, bao gồm các thành phần và tình trạng chẩn đoán, được khảo sát bằng cách sử dụng hồi quy tuyến tính và logistic. Đối với các thành phần của teo cơ, lượng cơ thấp (β = 162.8, p = 0.012) và sức mạnh (β = 181.31, p = 0.011) có mối tương quan đáng kể với sRAGE, nhưng không có mối tương quan với tốc độ đi lại thấp (p = 0.066). Về tình trạng bệnh, teo cơ đã được xác nhận (β = 436.93, p < 0.001), nhưng không phải nghi ngờ (p = 0.448) hoặc teo cơ nặng (p = 0.488), có mối tương quan đáng kể với sRAGE. Thêm vào đó, nữ giới cho thấy mối liên hệ mạnh mẽ hơn với mức độ sRAGE khi có mối tương quan đáng kể với lượng cơ thấp (β = 221.72, p = 0.014) và sức mạnh cơ thấp (β = 208.68, p = 0.043). Mức độ sRAGE cho thấy mối liên hệ tích cực với bệnh teo cơ, minh họa sự tham gia của nó trong sự phát triển của bệnh teo cơ. Mối liên hệ này rõ ràng hơn trong nhóm nữ, có thể do mất đi sự bảo vệ từ estrogen ở phụ nữ sau mãn kinh. Việc sử dụng mức độ sRAGE như một dấu hiệu tiềm năng cho bệnh teo cơ xứng đáng được nghiên cứu sâu hơn trong các nghiên cứu tương lai.

Từ khóa

#sRAGE #teo cơ #mất mát cơ bắp #phụ nữ sau mãn kinh #xét nghiệm miễn dịch liên kết enzyme

Tài liệu tham khảo

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