Electrochemical biosensors: perspective on functional nanomaterials for on-site analysis

Biomaterials Research - Tập 24 Số 1 - 2020
Il‐Hoon Cho1, Dong Hyung Kim2, Sangsoo Park3
1Department of Biomedical Laboratory Science, College of Health Science, Eulji University, Seongnam 13135, Republic of Korea
2Division of Advanced Instrumentation Institute, Korea Research Institute of Standards and Science (KRISS), 267 Gajeong-Ro, Yuseong-Gu, Daejeon, 34113, Republic of Korea
3Department of Biomedical Engineering, College of Health Science, Eulji University, Seongnam, 13135, Republic of Korea

Tóm tắt

Abstract Background The electrochemical biosensor is one of the typical sensing devices based on transducing the biochemical events to electrical signals. In this type of sensor, an electrode is a key component that is employed as a solid support for immobilization of biomolecules and electron movement. Thanks to numerous nanomaterials that possess the large surface area, synergic effects are enabled by improving loading capacity and the mass transport of reactants for achieving high performance in terms of analytical sensitivity. Main body We categorized the current electrochemical biosensors into two groups, carbon-based (carbon nanotubes and graphene) and non-carbon-based nanomaterials (metallic and silica nanoparticles, nanowire, and indium tin oxide, organic materials). The carbon allotropes can be employed as an electrode and supporting scaffolds due to their large active surface area as well as an effective electron transfer rate. We also discussed the non-carbon nanomaterials that are used as alternative supporting components of the electrode for improving the electrochemical properties of biosensors. Conclusion Although several functional nanomaterials have provided the innovative solid substrate for high performances, developing on-site version of biosensor that meets enough sensitivity along with high reproducibility still remains a challenge. In particular, the matrix interference from real samples which seriously affects the biomolecular interaction still remains the most critical issues that need to be solved for practical aspect in the electrochemical biosensor.

Từ khóa


Tài liệu tham khảo

10.3390/s17010074

10.1039/c3ay40972d

10.1111/j.1749-6632.1962.tb13623.x

10.1039/C5NR00585J

10.1039/C8RA09577A

10.1016/j.bios.2012.10.040

10.1039/C8RA04205E

10.1039/C6RA00333H

10.1039/C6AN00941G

10.3390/s18010207

10.1039/c0cc00954g

10.1039/c4tb00390j

10.3390/s19030588

10.1002/elan.200704028

10.1016/j.foodchem.2015.06.044

10.1016/j.electacta.2011.12.084

10.1016/j.bios.2008.10.006

10.1016/j.bios.2016.08.076

Aziz MA et al. Amperometric immunosensing using an indium tin oxide electrode modified with multi-walled carbon nanotube and poly (ethylene glycol)–silane copolymer. Chem Commun. 2007:2610–2.

10.1021/ja062117e

10.1016/j.bios.2016.12.007

10.1016/j.bios.2016.08.004

10.1016/j.bios.2019.05.016

10.1021/acs.analchem.6b02945

10.1016/j.aca.2015.11.014

10.1039/b518111a

10.1002/adma.201301219

10.3390/s90402289

10.1039/C7TB00748E

10.1016/j.aca.2009.05.017

10.1016/j.snb.2017.04.026

10.1039/C0CC03928D

10.1021/ja9038054

10.1039/C8NR07379A

10.1002/chem.201101182

10.3390/s19020392

10.1016/j.aca.2008.05.070

10.1016/j.bios.2016.03.062

10.1016/j.elecom.2007.03.007

10.1002/mabi.200300034

10.1016/j.snb.2007.01.024

10.1002/elan.200603805

10.1016/j.bios.2013.08.012

10.1016/j.colsurfa.2015.07.005

10.1039/C6RA25318K

10.1016/j.snb.2013.04.040

10.1016/j.bios.2011.05.039

10.1016/j.tibtech.2011.01.008

10.1021/nn800244k

10.1016/j.apsusc.2014.01.101

10.1038/s41598-017-05352-7

10.20964/2016.12.90

10.1038/srep35440

10.1016/j.bios.2016.12.049

10.1038/srep42361

10.1016/j.snb.2011.10.085

10.1021/cm062791v

10.1016/j.bios.2008.11.011

10.1002/elan.200704125

10.1021/ac702496k

10.1016/j.electacta.2004.08.052

10.1002/elan.200900571

10.1039/C7TA10210K

10.1016/j.talanta.2013.08.041

10.1016/j.bios.2016.02.066

10.1016/j.bios.2016.06.048

10.1016/j.bios.2013.05.029

10.1016/j.cbpa.2008.08.027

10.3390/ma7064669

Khan MZH. Effect of ITO surface properties on SAM modification: a review toward biosensor application. Cogent Engineering. 2016;3:1170097.

10.1007/s00604-013-0956-0

Anatoliy NS, et al. Fabrication of low-cost electronic biosensors. Mater Today. 2009;12:12–20.

10.1016/j.bios.2015.12.080

10.1016/j.bios.2016.04.100

10.1016/j.bios.2016.12.070

10.1016/j.bios.2016.05.063

10.1016/j.bios.2016.01.030

10.1016/j.bios.2016.10.066

10.1016/j.bios.2016.12.057

10.1016/j.bios.2016.09.014

10.1016/j.bios.2015.10.008

10.1039/C6AN00694A

10.1039/C6CC00353B

10.1016/j.electacta.2013.12.144

10.1021/ac302883c

10.1021/ac050558v

10.1016/j.elecom.2016.12.015

10.1016/j.bios.2016.05.084

10.1021/ac3001435

10.1016/j.bios.2016.04.102

10.1021/ja043581r

10.1002/adfm.200701340

10.1016/j.bios.2010.03.006

10.1021/jp060601y

10.1016/S0926-860X(01)00847-X

10.1016/S0928-4931(01)00449-0

10.1023/A:1016685130974

10.1016/j.jelechem.2012.03.023

10.1504/IJBNN.2011.040997

10.1088/0957-4484/21/21/215601

10.1016/j.carbon.2008.12.049

10.1016/j.bios.2008.07.043

10.1039/C8AY02150C

10.1016/S0168-1656(98)00156-4

10.1021/cm051442i

10.1021/la011345d

10.1016/j.bios.2016.09.048

10.1016/j.catcom.2010.12.012

10.1007/s00216-006-0976-2

10.1016/j.snb.2013.11.010

10.1016/j.ab.2016.12.006

10.1007/s00604-011-0566-7

10.1021/ja070440r

10.1002/anie.200352630

10.1002/anie.200462668

10.1126/science.1140484

10.1039/C6CC08885F

10.1021/acsami.6b01010

10.1021/nl080366q

10.1021/ac070639m

10.1039/C5TC00755K

10.1021/nl302434w

10.1016/0040-6090(83)90256-0

10.3390/coatings8060212

10.1063/1.4923397

10.3390/s17010054

10.1021/ac902426c

10.1016/j.electacta.2011.06.056

Thông tin
Thông tin xuất bản

Biomaterials Research

Tập 24 Số 1

Thông tin tác giả