Effects of traumatic brain injury and posttraumatic stress disorder on development of Alzheimer's disease in Vietnam Veterans using the Alzheimer's Disease Neuroimaging Initiative: Preliminary report

Alzheimer's and Dementia: Translational Research and Clinical Interventions - Tập 3 - Trang 177-188 - 2017
Michael W. Weiner1,2,3,4,5, Danielle Harvey6, Jacqueline Hayes1, Susan M. Landau7, Paul S. Aisen8, Ronald C. Petersen9, Duygu Tosun1, Dallas P. Veitch1, Clifford R. Jack10, Charles Decarli11, Andrew J. Saykin12,13, Jordan Grafman14, Thomas C. Neylan4
1Department of Veterans Affairs Medical Center, Center for Imaging of Neurodegenerative Diseases, San Francisco, CA, USA
2Department of Radiology, University of California, San Francisco, CA, USA
3Department of Medicine, University of California, San Francisco, CA USA
4Department of Psychiatry, University of California, San Francisco, CA, USA
5Department of Neurology, University of California, San Francisco, CA, USA
6Division of Biostatistics, Department of Public Health Sciences, University of California, Davis, CA, USA
7Helen Wills Neuroscience Institute, University of California, Berkeley, CA USA
8Alzheimer's Therapeutic Research Institute, Keck School of Medicine, University of Southern California, San Diego, CA, USA
9Department of Neurology, Mayo Clinic, Rochester, MN, USA
10Department of Radiology, Mayo Clinic, Rochester, MN, USA
11Imaging of Dementia and Aging (IDeA) Laboratory, Department of Neurology and Center for Neuroscience, University of California, Davis, CA, USA
12Indiana Alzheimer Disease Center, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA
13Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA
14Psychiatry and Behavioral Sciences & Cognitive Neurology/Alzheimer's Disease Research Center, Feinberg School of Medicine and Department of Psychology, Northwestern University, Chicago, IL, USA

Tóm tắt

AbstractIntroductionTraumatic brain injury (TBI) and posttraumatic stress disorder (PTSD) have previously been reported to be associated with increased risk of Alzheimer's disease (AD). We are using biomarkers to study Vietnam Veterans with/without mild cognitive impairment with a history of at least one TBI and/or ongoing PTSD to determine whether these contribute to the development of AD.MethodsPotential subjects identified by Veterans Administration records underwent an initial telephone screen. Consented subjects underwent clinical evaluation, lumbar puncture, structural magnetic resonance imaging, and amyloid positron emission tomography (PET) scans.ResultsWe observed worse cognitive functioning in PTSD and TBI + PTSD groups, worse global cognitive functioning in the PTSD group, lower superior parietal volume in the TBI + PTSD group, and lower amyloid positivity in the PTSD group, but not the TBI group compared to controls without TBI/PTSD. Medial temporal lobe atrophy was not increased in the PTSD and/or TBI groups.DiscussionPreliminary results do not indicate that TBI or PTSD increase the risk for AD measured by amyloid PET. Additional recruitment, longitudinal follow‐up, and tau‐PET scans will provide more information in the future.

Tài liệu tham khảo

10.1001/archneurol.2011.100 10.1002/(SICI)1099-1166(199703)12:3<363::AID-GPS515>3.0.CO;2-F Duijn C.M., 1992, Head trauma and the risk of Alzheimer's disease, Am J Epidemiol, 135, 775, 10.1093/oxfordjournals.aje.a116364 10.1093/ije/20.Supplement_2.S28 10.1002/ana.410330513 10.1093/oxfordjournals.aje.a009290 10.1093/oxfordjournals.aje.a115523 10.1136/jnnp.62.2.119 10.1002/ana.410150406 10.1212/WNL.41.10.1554 10.1002/ana.410250402 10.1212/WNL.52.1.78 10.1212/WNL.53.9.1959 Mayeux R., 1996, Apolipoprotein e4 and head trauma: synergistic or additive risks?, Neurology, 46, 889 Katzman R., 1996, Apolipoprotein‐epsilon4 and head trauma: synergistic or additive risks?, Neurology, 46, 889 Frankowski R.F., 1985, Central Nervous System Trauma Status Report –1985, 33 10.1212/WNL.45.3.555 10.1093/oxfordjournals.aje.a009724 10.1111/j.1532-5415.1989.tb07283.x 10.1136/jnnp.74.7.857 10.3109/02699059509008194 10.1212/WNL.40.11.1698 10.1212/WNL.36.7.922 10.1212/WNL.39.12.1576 10.1212/WNL.37.8.1295 10.1136/jech.49.3.253 10.1159/000110750 10.1002/ana.410330306 10.1212/WNL.42.8.1481 10.1212/WNL.44.11.2073 10.1212/WNL.35.2.264 10.1017/S104161029700447X 10.1212/WNL.55.8.1158 10.1038/nrn2808 Williams J.W., 2010, Preventing Alzheimer's disease and cognitive decline, Evid Rep Technol Assess (Full Rep), 193, 1 10.1016/B978-0-444-63521-1.00044-3 10.1097/00019052-200412000-00012 Jordan B.D., 1997, Apolipoprotein E epsilon4 associated with chronic traumatic brain injury in boxing, JAMA, 278, 136, 10.1001/jama.1997.03550020068040 10.1212/WNL.52.2.244 10.1212/WNL.55.10.1536 10.1046/j.1468-1331.2001.00322.x 10.1001/archneur.60.6.818 10.1136/mp.56.3.132 10.1136/jnnp.2005.085167 10.1136/jnnp.2006.095513 10.1038/nm0295-135 10.1136/jnnp.57.4.419 10.1016/j.expneurol.2007.06.018 Mielke M.M., 2014, Head trauma and in vivo measures of amyloid and neurodegeneration in a population‐based study, Neurology, 82, 70, 10.1212/01.wnl.0000438229.56094.54 10.1076/1385-4046(200002)14:1;1-8;FT007 10.1016/j.neuron.2007.09.006 Kulka R.A., 1990, Trauma and the Vietnam War Generation 10.1126/science.1128944 10.1037/0894-4105.20.6.716 10.1023/A:1011181305501 10.1037/0894-4105.16.1.5 10.1176/ajp.150.7.1015 10.1007/BF02688613 10.1176/ajp.152.1.137 10.1007/BF00964322 10.1037/0894-4105.12.1.125 10.1016/j.psychres.2008.01.001 10.1111/j.1749-6632.1997.tb48319.x 10.1016/S0006-3223(01)01245-8 10.1016/j.pscychresns.2007.04.011 10.1001/archgenpsychiatry.2009.205 10.1016/j.biopsych.2010.09.044 10.1001/archgenpsychiatry.2009.160 10.1177/1073858409333072 10.1001/archgenpsychiatry.2010.61 10.1016/j.jalz.2014.11.001 10.1097/01.HTR.0000300227.67748.77 10.1017/S0033291700033183 Breitner J.C., 1995, Diagnosis and management of memory loss and cognitive disorders among elderly persons, Psychiatr Serv, 46, 29, 10.1176/ps.46.1.29 10.1007/s10862-009-9141-5 10.1016/0165-1781(89)90047-4 10.1016/S0895-4356(98)00109-7 10.1037/1040-3590.1.1.53 10.1002/jts.2490080106 Wolfe J., 1993, The Life Stressor Checklist 10.1016/j.drugalcdep.2006.09.002 10.1016/j.jalz.2015.05.003 10.1016/j.jalz.2010.03.013 10.1002/jmri.21049 10.1016/j.jalz.2015.05.001 10.1016/j.jalz.2015.05.005 10.1007/978-1-4899-3242-6 SAS SIIVotSSfWSaaoSIIposnartoto. 10.1002/ana.23650 10.1002/gps.2763 10.4088/JCP.12m08291 10.1016/j.jalz.2014.04.008 10.1016/j.jalz.2014.04.004 10.1176/appi.neuropsych.23.1.16 10.1111/j.1532-5415.2010.02977.x 10.1176/ajp.152.7.973 10.1016/S0006-3223(96)00229-6 10.1097/00146965-200312000-00003 Woodward S.H., 2006, Hippocampal volume, PTSD, and alcoholism in combat veterans, Am J Psychiatry, 163, 674, 10.1176/ajp.2006.163.4.674 10.1176/appi.ajp.158.8.1248 10.1016/S0006-3223(99)00045-1 10.1016/S0006-3223(02)01413-0 10.1093/brain/awp007 10.1001/jamaneurol.2016.1948
Thông tin
Thông tin xuất bản

Alzheimer's and Dementia: Translational Research and Clinical Interventions

Tập 3

177-188

Thông tin tác giả