Effects of the γ-aminobutyric acid antagonist disulfotetraazaadamantane on evoked neuronal response in hippocampal slices
Tóm tắt
The effects were investigated of disulfotetraazaadamantane (DSTA), a blocker of γ-aminobutyric acid, on summated potentials in field CA 1 of the mouse hippocampus arising in response to electrical stimulation of Shaffer's collateral. At a concentration of 5·10−6–10−5 M, DSTA led to a considerable increase in the amplitude of the main population spike (PS) and the onset of additional PS. The effects induced by DSTA resembled those observed following picrotoxin application, which it exceeded two- to threefold in intensity, however. Findings are reviewed from the standpoint of the effects exerted by the test substance on synaptic processes in the hippocampus in vitro.
Tài liệu tham khảo
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