Effects of spermidine treatment on neurobehavioral development in intrauterine growth retarded (IUGR) rats

International Journal of Developmental Neuroscience - Tập 17 - Trang 727-732 - 1999
Gülay Üzüm1, A.Sarper Diler1,2, Ziya Ziylan1
1Department of Physiology, Istanbul Medical Faculty, Capa 34390, Istanbul, Turkey
2Department of Medical Biology, Istanbul Medical Faculty, Capa 34390, Istanbul, Turkey

Tóm tắt

AbstractIt was previously shown that polyamine treatment could induce precocious development of several somatic and neurobehavioral functions in newborn rats. This study investigates the effects of daily injections of spermidine (SPMD) 50 μl/10 g s.c. on neurobehavioral development of newborn rats experiencing undernutrition. Neurobehavioral development was assessed by measurements of gripping and righting reflexes. SPMD treated intrauterine growth retarded (IUGR) rats reached righting reflex control values at 30 days postnatal (1.87±0.78 s vs 1.75±0.66 s). Beginning from 7 days postnatal, gripping reflex values of SPMD treated IUGR rats declined, reaching that of controls at 30 days postnatal (1.77±91° vs 1.82±65°). These results suggest the utility of exogenous SPMD in rats experiencing undernutrition, thus indicating a clinical relevance.

Tài liệu tham khảo

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International Journal of Developmental Neuroscience

Tập 17

727-732

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