Effects of neonatal (+)‐methamphetamine on path integration and spatial learning in rats: effects of dose and rearing conditions

International Journal of Developmental Neuroscience - Tập 26 - Trang 599-610 - 2008
Charles V. Vorhees1, Nicole R. Herring1, Tori L. Schaefer1, Curtis E. Grace1, Matthew R. Skelton1, Holly L. Johnson1, Michael T. Williams1
1Division of Neurology, Department of Pediatrics, Cincinnati Children's Research Foundation and University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229, United States

Tóm tắt

AbstractPostnatal day (P)11–20 (+)‐methamphetamine (MA) treatment impairs spatial learning and reference memory in the Morris water maze, but has marginal effects on learning in a labyrinthine maze. A subsequent experiment showed that MA treatment on P11–15, but not P16–20, is sufficient to induce Morris maze deficits. Here we tested the effects of P11–15 MA treatment under two different rearing conditions on Morris maze performance and path integration learning in the Cincinnati water maze in which distal cues were unavailable by using infrared illumination. Littermates were treated with 0, 10, 15, 20, or 25 mg/kg MA × 4/day (2 h intervals). Half the litters were reared under standard housing conditions and half under partial enrichment by adding stainless steel enclosures. All MA groups showed impaired Cincinnati water maze performance with no significant effects of rearing condition. In the Morris maze, the MA‐25 group showed impaired spatial acquisition, reversal, and small platform learning. Enrichment significantly improved Morris maze acquisition in all groups but did not interact with treatment. The male MA‐25 group was also impaired on probe trial performance after acquisition and on small platform trials. A narrow window of MA treatment (P11–15) induces impaired path integration learning irrespective of dose within the range tested but impairments in spatial learning are dependent on dose. The results demonstrate that a narrower exposure window (5 days) changes the long‐term effects of MA treatment compared to longer exposures (10 days).

Tài liệu tham khảo

10.1038/sj.npp.1301091 10.1016/0892-0362(95)02015-2 10.1038/378182a0 Bayer S.A., 1993, Timetables of neurogenesis in the human brain based on experimentally determined patterns in the rat, Neurotoxicology, 14, 83 10.1016/j.bbr.2003.08.019 10.3109/00207458909002151 Burgess N., 2002, The hippocampus, space, and viewpoints in episodic memory, Q. J. Exp. Psychol., 55, 1057, 10.1080/02724980244000224 10.1016/j.bbr.2006.02.023 10.1515/REVNEURO.1996.7.3.215 10.1037/0735-7044.110.1.86 10.1016/j.pscychresns.2004.06.004 Chomchai C., 2004, Methamphetamine abuse during pregnancy and its health impact on neonates born at Siriraj Hospital, Bangkok, Thailand, Southeast Asian J. Trop. Med. Public Health, 35, 228 10.1016/j.neuro.2007.01.014 10.1385/NI:5:1:79 10.1002/syn.10197 10.1016/S0165-0173(01)00067-4 Dixon S.D., 1989, Effects of transplacental exposure to cocaine and methamphetamine on the neonate, Western J. Med., 150, 436 10.1016/S0022-3476(89)80661-4 10.1111/1467-8721.ep11509737 10.1002/hipo.10173 10.1523/JNEUROSCI.4353-05.2006 10.1037/0735-7044.107.4.618 10.1016/j.expneurol.2004.03.027 10.1037/0735-7044.111.6.1285 L.D. Johnston P.M. O'Malley J.G. Bachman J.E. Schulenberg 2006a.Monitoring the Future: National Survey Results on Drug Use 1975–2005: vol. I Secondary School Students.National Institute on Drug Abuse U.S. Department of Health and Human Services Bethesda MD. L.D. Johnston P.M. O'Malley J.G. Bachman J.E. Schulenberg 2006b.Monitoring the Future: National Survey Results on Drug Use 1975–2005: vol. II College Students and Adults Ages 19–45.National Institute on Drug Abuse U.S. Department of Health and Human Services Bethesda MD. Little B.B., 1988, Methamphetamine abuse during pregnancy: outcome and fetal effects, Obstet. Gynecol., 72, 541 10.1023/A:1011477931753 10.1016/0165-0173(93)90006-L 10.1038/nrn1932 10.1016/0163-1047(92)90387-J 10.1098/rstb.2002.1264 10.1016/0023-9690(81)90020-5 10.1016/S0022-3476(87)80125-7 10.1037/0735-7044.110.6.1309 10.1289/ehp.00108s3511 10.1523/JNEUROSCI.3408-05.2006 10.1016/0165-0173(86)90010-X 10.1126/science.1125572 10.1038/378186a0 10.1037/0735-7044.110.1.103 10.1111/j.1471-4159.2006.04034.x Schaefer T.L., 2007, Short‐ and long‐term effects of (+)‐methamphetamine and (+/−)‐3,4‐methylenedioxymethamphetamine on monoamine and corticosterone levels in the neonatal rat following multiple days of treatment, J. Neurochem., 104, 1674, 10.1111/j.1471-4159.2007.05112.x 10.1016/j.psyneuen.2007.05.004 10.1016/j.devbrainres.2005.04.005 10.1212/WNL.57.2.255 10.1542/peds.2005-2564 10.1097/00004703-199204000-00005 10.1016/0892-0362(87)90008-0 10.1007/BF02249328 10.1007/BF02249329 Vorhees C.V., 2000, Adult learning deficits after neonatal exposure to d, ‐methamphetamine: selective effects on spatial navigation and memory, J. Neurosci., 20, 4732, 10.1523/JNEUROSCI.20-12-04732.2000 Vorhees C.V., 1999, Genetic differences in spatial learning between Dark Agouti and Sprague‐Dawley strains: possible correlation with CYP2D2 polymorphism in rats treated neonatally with methamphetamine, Pharmacogenetics, 9, 171 10.1016/S0892-0362(97)00129-3 10.1097/FBP.0b013e3282ee2abe 10.1038/nprot.2006.116 West J.R., 1987, Alcohol and Brain Development, 120 Whishaw I.Q., 1998, Rats with fimbria‐fornix lesions are impaired in path integration: a role for the hippocampus in “sense of direction”, J. Neurosci., 18, 3050, 10.1523/JNEUROSCI.18-08-03050.1998 10.1016/S0959-4388(97)80011-6 10.1016/S0892-0362(00)00091-X 10.1007/s00213-003-1433-y 10.1016/j.ijdevneu.2004.04.003 10.1016/S0006-8993(02)04278-6 10.1002/syn.10159 10.1080/10253890600902842 10.1016/S0006-8993(02)03620-X 10.1126/science.1126912
Thông tin
Thông tin xuất bản

International Journal of Developmental Neuroscience

Tập 26

599-610

Thông tin tác giả