Effects of growth hormone on hepatic cholesterol metabolism. Lessons from studies in rats and humans

Lipid Research Clinics Program, 1984, The Lipid Research Clinics Coronary Primary Prevention trial results. I. Reduction in incidence of coronary heart disease, JAMA, 251, 351, 10.1001/jama.1984.03340270029025

Sacks, 1996, The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels, N Engl J Med, 335, 1001, 10.1056/NEJM199610033351401

Bilheimer, 1984, Liver transplantation to provide low-density-lipoprotein receptors and lower plasma cholesterol in a child with homozygous familialhypercholesterolemia, N Engl J Med, 311, 1658, 10.1056/NEJM198412273112603

Valdivielso, 1988, Lipids and lipoprotein changes after heart and liver transplantation in a patient with homozygous familial hypercholesterolemia, Ann Intern Med, 108, 204, 10.7326/0003-4819-108-2-204

Spady, 1997, Overexpression of cholesterol 7α-hydroxylase (CYP/a) in mice lacking the low density lipoprotein (LDL) receptor gene, J Biol Chem, 273, 126, 10.1074/jbc.273.1.126

Brown, 1986, A receptor-mediated pathway for cholesterol homeostasis, Science, 232, 34, 10.1126/science.3513311

Myant, 1990

Brindley, 1991, Hormonal regulation of the hepatic low density lipoprotein receptor and the catabolism of low density lipoproteins: relationship with the secretionof very low density lipoproteins, Prog Lipid Res, 30, 349, 10.1016/0163-7827(91)90003-N

Angelin, 1992, Hepatic cholesterol metabolism in estrogen-treated men, Gastroenterology, 103, 1657, 10.1016/0016-5085(92)91192-7

Kovanen, 1979, Increased binding of low density lipoprotein to liver membranes from rats treated with 17alpha-ethinyl estradiol, J Biol Chem, 254, 11367, 10.1016/S0021-9258(19)86495-5

Rudling, 1987, Role of the liver for the receptor-mediated catabolism of low-density lipoprotein in the 17 alphaethinylestradiol-treated rat, Acta Biochem Biophys, 919, 175, 10.1016/0005-2760(87)90205-0

Friedman, 1970, Pituitary growth hormone essential for regulation of serum cholesterol, Nature, 255, 464, 10.1038/225464a0

Barett-Connor, 1996, Sex differences in coronary heart disease. Why are women so superior?, Circulation, 95, 252

Bush, 1990, The epidemiology of cardiovascular disease in postmenopausal women, Ann N Y Acad Sci, 592, 263, 10.1111/j.1749-6632.1990.tb30338.x

Barett-Connor, 1992, Risks and benefits of replacement estrogen, Annu Rev Med, 43, 239, 10.1146/annurev.me.43.020192.001323

Sullivan, 1996, Estrogen replacement, Circulation, 94, 2699, 10.1161/01.CIR.94.11.2699

Rudling, 1996, Regulation of rat hepatic low density lipoprotein receptors. n vivo stimulation by growth hormone is not mediated by insulin-like growth factor, J Clin Invest, 97, 292, 10.1172/JCI118415

Norstedt, 1981, Multihormonal regulation of the estrogen receptor in rat liver, Endocrinology, 108, 1190, 10.1210/endo-108-4-1190

Parini, 1997, Importance of estrogen receptors in hepatic low density lipoprotein receptor regulation, Arterioscler Thromb Vasc Biol, 17, 1800, 10.1161/01.ATV.17.9.1800

Rudling, 1993, Loss of resistance to dietary cholesterol in the rat following hypophysectomy: importance of growth hormone for the expression of hepatic lowdensity lipoprotein receptors, 90, 8851

Parini, 1999, Cholesterol and lipoprotein metabolism in aging: reversal of hypercholesterolemia by growth hormone treatment in old rats, Arterioscler Thromb Vasc Biol, 10.1161/01.ATV.19.4.832

Parini, 1995, Growth hormone specifically stimulates the expression of low density lipoprotein receptors in human hepatoma cells, Endocrinology, 136, 3767, 10.1210/endo.136.9.7649083

Rudling, 1997, Growth hormone and bile acid synthesis. Key role for the activity of hepatic microsomal cholesterol 7α-hydroxylase in the rat, J Clin Invest, 99, 2239, 10.1172/JCI119398

Heubi, 1983, The role of human growth hormone in the regulation of cholesterol and bile acid metabolism, J Clin Endocrinol Metab, 57, 885, 10.1210/jcem-57-5-885

Elam, 1988, Stimulation of in vitro triglyceride synthesis in the rat hepatocyte by growth hormone treatment in vivo, Endocrinology, 122, 1397, 10.1210/endo-122-4-1397

Elam, 1992, In vivo growth hormone treatment stimulates secretion of very low density lipoprotein by the isolated perfused rat liver, Endocrinology, 131, 2717, 10.1210/endo.131.6.1446613

Sjöberg, 1992, Effects of growth hormone on apolipoprotein-B (apoB) messenger ribonucleic acid editing, and apoB48 and apoB100 synthesis and secretion in the rat liver, Endocrinology, 130, 3356, 10.1210/endo.130.6.1597147

Johnston, 1992, Metabolic changes and vascular risk factors in hypopituitarism, Horm Res, 38, 68, 10.1159/000182573

Edén, 1993, Growth hormone treatment of growth hormone-deficient adults results in a marked increase in Lp(a) and HDL cholesterol concentrations, Arterioscler Thromb, 13, 296, 10.1161/01.ATV.13.2.296

Abbott, 1983, Joint distribution of lipoprotein cholesterol classes. The Framingham study, Arteriosclerosis, 3, 260, 10.1161/01.ATV.3.3.260

Miller, 1984, Why does plasma low density lipoprotein concentration in adults increase with age?, Lancet, 1, 263, 10.1016/S0140-6736(84)90135-1

Einarsson, 1985, Influence of age on secretion of cholesterol and synthesis of bile acids by the liver, N Engl J Med, 313, 277, 10.1056/NEJM198508013130501

Olivecrona, 1993, Increased concentrations of serum lipoprotein(a) in response to growth hormone treatment, BMJ, 306, 1726, 10.1136/bmj.306.6894.1726-a