Effects of fasting and gender on ochratoxin A toxicokinetics in F344 rats

Food and Chemical Toxicology - Tập 48 - Trang 3159-3166 - 2010
A. Vettorazzi1, I.F. Trocóniz2, E. Gonzalez-Peñas3, L.A. Corcuera1, L. Arbillaga1, A.G. Gil1, J.M. Nagy4, P.G. Mantle5, A. López de Cerain1
1Department of Nutrition and Food Sciences, Physiology and Toxicology, Faculty of Pharmacy, University of Navarra, Irunlarrea 1, E-31008 Pamplona, Spain
2Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Navarra, Irunlarrea 1, E-31008 Pamplona, Spain
3Department of Organic and Pharmaceutical Chemistry, Faculty of Pharmacy, University of Navarra, Irunlarrea 1, E-31008 Pamplona, Spain
4Institute of Biomedical Engineering, Imperial College London, London SW7 2AZ, UK
5Center for Environmental Policy, Imperial College London, London SW7 2AZ, UK

Tài liệu tham khảo

Alvarez, 2004, Immunotoxic effects of ochratoxin A in Wistar rats after oral administration, Food Chem. Toxicol., 42, 825, 10.1016/j.fct.2004.01.005 Aoudia, 2008, Distribution of ochratoxin A in plasma and tissues of rats fed a naturally contaminated diet amended with micronized wheat fibres: effectiveness of mycotoxin sequestering activity, Food Chem. Toxicol., 46, 871, 10.1016/j.fct.2007.10.029 Avantaggiato, 2007, Assessment of the multi-mycotoxin-binding efficacy of a carbon/aluminosilicate-based product in an in vitro gastrointestinal model, J. Agric. Food. Chem., 55, 4810, 10.1021/jf0702803 Beal, 1989 Belmadani, 1998, Regional selectivity to ochratoxin A, distribution and cytotoxicity in rat brain, Arch. Toxicol., 72, 656, 10.1007/s002040050557 Bendele, 1985, Ochratoxin A carcinogenesis in the (C57BL/6J X C3H)F1 mouse, J. Natl Cancer Inst., 75, 733 Berger, 2003, Interaction of ochratoxin A with human intestinal Caco-2 cells: possible implication of a multidrug resistance-associated protein (MRP2), Toxicol. Lett., 140–141, 465, 10.1016/S0378-4274(03)00043-2 Breitholtz-Emanuelsson, 1995, Toxicokinetics of ochratoxin A in rat following intratracheal administration, Nat. Toxins, 3, 101, 10.1002/nt.2620030207 Castegnaro, 1998, Sex- and strain-specific induction of renal tumors by ochratoxin A in rats correlates with DNA adduction, Int. J. Cancer, 77, 70, 10.1002/(SICI)1097-0215(19980703)77:1<70::AID-IJC12>3.0.CO;2-D Denli, 2008, Efficacy of a new ochratoxin-binding agent (OcraTox) to counteract the deleterious effects of ochratoxin A in laying hens, Poult. Sci., 87, 2266, 10.3382/ps.2008-00024 Diehl, 2001, A good practice guide to the administration of substances and removal of blood, including routes and volumes, J. Appl. Toxicol., 21, 15, 10.1002/jat.727 Dietrich, 2005, Ochratoxin A: comparative pharmacokinetics and toxicological implications (experimental and domestic animals and humans), Food Addit. Contam., 22, 45, 10.1080/02652030500309327 EFSA (European Food Safety Authority), 2006. Opinion of the scientific panel on contaminants in the food chain on a request from the Commission related to ochratoxin A in food. Adopted on 4 April 2006. The EFSA Journal 365, 1–56. Food and Drug Administration, US Department of Health and Human Services, Center for Drug evaluation and research (CDER), 2002. Guidance for industry. Food-effect bioavailability and fed bioequivalence studies. Galtier, 1979, The pharmacokinetic profile of ochratoxin A in the rat after oral and intravenous administration, Drug Metab. Dispos., 7, 429 Garrido, 1999, Altered plasma and brain disposition and pharmacodynamics of methadone in abstinent rats, J. Pharmacol. Exp. Ther., 288, 179 Hagelberg, 1989, Toxicokinetics of ochratoxin A in several species and its plasma-binding properties, J. Appl. Toxicol., 9, 91, 10.1002/jat.2550090204 Huwig, 2001, Mycotoxin detoxication of animal feed by different adsorbents, Toxicol. Lett., 122, 179, 10.1016/S0378-4274(01)00360-5 IARC, 1993. Ochratoxin A. Some naturally occurring substances: food items and constituents, heterocyclic aromatic amines and mycotoxins. IARC Monographs on the evaluation of carcinogenic risks to humans 56, 489–521. Kane, 1986, Distribution of the [3H]-label from low doses of radioactive ochratoxin A ingested by rats, and evidence for DNA single-strand breaks caused in liver and kidneys, Arch. Toxicol., 58, 219, 10.1007/BF00297109 Kumagai, 1982, Intestinal absorption and secretion of ochratoxin A in the rat, Toxicol. Appl. Pharmacol., 64, 94, 10.1016/0041-008X(82)90326-X Li, 1997, Pharmacokinetics of ochratoxin A and its metabolites in rats, Toxicol. Appl. Pharmacol., 145, 82, 10.1006/taap.1997.8155 Mantle, 2008, Binding of a ochratoxin A to a urinary globulin: a new concept to account for gender difference in rat nephrocarcinogenic responses, Int. J. Mol. Sci., 9, 719, 10.3390/ijms9050719 Mantle, 2005, Renal tumourigenesis in male rats in response to chronic dietary ochratoxin A, Food Addit. Contam., 22, 58, 10.1080/02652030500358431 Miljkovic, 2003, Comparative responses to mode of oral administration and dose of ochratoxin A or nephrotoxic extract of Penicillium polonicum in rats, Exp. Toxicol. Pathol., 54, 305, 10.1078/0940-2993-00262 National Toxicology Program (NTP), 1989. Toxicology and carcinogenesis studies of ochratoxin A (CAS No 303-47-9) in F344/N rats (gavage studies). Nat. l Toxicol. Program Tech. Rep. Ser. 358, 1–142. O’Brien, 2005, Ochratoxin A: the continuing enigma, Crit. Rev. Toxicol., 35, 33, 10.1080/10408440590905948 OECD Guideline for testing of chemicals, Number 417. Adoped 4 April 1984, Toxicokinetics. Pfohl-Leszkowicz, 2007, Ochratoxin A: an overview on toxicity and carcinogenicity in animals and humans, Mol. Nutr. Food Res., 51, 61, 10.1002/mnfr.200600137 Pfohl-Leszkowicz, 2002, Balkan endemic nephropathy and associated urinary tract tumours: a review on aetiological causes and the potential role of mycotoxins, Food Addit. Contam., 19, 282, 10.1080/02652030110079815 Rasonyi, 1999, The role of alpha2u-globulin in ochratoxin A induced renal toxicity and tumors in F344 rats, Toxicol. Lett., 104, 83, 10.1016/S0378-4274(98)00347-6 Ringot, 2006, Toxicokinetics and toxicodynamics of ochratoxin A, an update, Chem. Biol. Interact., 159, 18, 10.1016/j.cbi.2005.10.106 Rodgers, 1993, Interpretation of male rat renal tubule tumors, Environ. Health Perspect., 101, 45, 10.1289/ehp.93101s645 Sava, 2006, Acute neurotoxic effects of the fungal metabolite ochratoxin-A, Neurotoxicology, 27, 82, 10.1016/j.neuro.2005.07.004 Schrickx, 2006, Ochratoxin A secretion by ATP-dependent membrane transporters in Caco-2 cells, Arch. Toxicol., 80, 243, 10.1007/s00204-005-0041-5 Shargel, 2005 Son, 2003, Strain-specific mammary proliferative lesion development following lifetime oral administration of ochratoxin A in DA and Lewis rats, Int. J. Cancer, 105, 305, 10.1002/ijc.11069 Stoev, 2002, Spontaneous mycotoxic nephropathy in Bulgarian chickens with unclarified mycotoxin aetiology, Vet. Res., 33, 83, 10.1051/vetres:2001008 Suzuki, 1977, The pharmacokinetics of ochratoxin A in rats, Jpn. J. Pharmacol., 27, 735, 10.1254/jjp.27.735 Swenberg, 1993, Alpha 2u-globulin nephropathy: review of the cellular and molecular mechanisms involved and their implications for human risk assessment, Environ. Health Perspect., 101, 39, 10.1289/ehp.93101s639 Tanaka, 2005, Tissue distribution and hormonal regulation of the breast cancer resistance protein (Bcrp/Abcg2) in rats and mice, Biochem. Biophys. Res. Commun., 326, 181, 10.1016/j.bbrc.2004.11.012 Vettorazzi, 2008, Simple high-performance liquid chromatography-fluorescence detection method for plasma, kidney and liver of rat as a tool for toxicology studies, J. Chromatogr. A, 1215, 100, 10.1016/j.chroma.2008.10.119 Vettorazzi, 2009, A different kinetic profile of ochratoxin A in mature male rats, Food Chem. Toxicol., 47, 1921, 10.1016/j.fct.2009.05.003 Wait, 2001, Proteins of rat serum, urine, and cerebrospinal fluid: VI. Further protein identifications and interstrain comparison, Electrophoresis, 22, 3043, 10.1002/1522-2683(200108)22:14<3043::AID-ELPS3043>3.0.CO;2-M WHO (World Health Organisation), 2001. Safety evaluation of certain mycotoxins in food. WHO Food Additives Series, No. 47. Zepnik, 2003, Toxicokinetics of the mycotoxin ochratoxin A in F344 rats after oral administration, Toxicol. Appl. Pharmacol., 192, 36, 10.1016/S0041-008X(03)00261-8