Effects of dietary cholesterol upon bile acid metabolism in guinea pig

Lipids - Tập 9 Số 10 - Trang 731-737 - 1974
Heleni Lansma1,2, Rosemarie Ostwald3
1Biological Sciences Department, University of California, Santa Barbara, Calif., 93106
2
3Department of Nutritional Sciences, University of California, Berkeley

Tóm tắt

AbstractCholesterol fed guinea pigs develop a hemolytic anemia accompanied by high cholesterol concentrations in the liver, plasma, and red cells. We have studied the bile acid metabolism of guinea pigs fed a diet with or without cholesterol in a search for the factor(s) which prevent adequate control of their body cholesterol pool and, therefore, its pathological consequences. The results show that in the cholesterol fed guinea pig the synthesis (and excretion) of bile acids was at least three times greater than in controls. This is the result of a doubling of the fractional turnover rate and a smaller increase in the pool size. The major increase of the bile acid pool was in the liver. The main bile acid in gall bladder bile and small intestines was chenodeoxycholic acid, with smaller amounts of 7‐ketolithocholic and ursodeoxycholic acids. In the caecum, large intestines, and feces, the major bile acid was lithocholic acid.

Từ khóa


Tài liệu tham khảo

10.1016/S0021-9258(18)73656-9

10.1042/bj0910146

Ostwald R. W.Yamanaka M.Light andJ.Kroes Abstracts 0–14 VIII International Congress of Nutrition August 1969 Prague Czechoslovakia.

10.3181/00379727-134-34890

10.1016/S0022-2275(20)38982-3

10.1021/bi00875a040

10.1016/S0022-2275(20)43123-2

Eneroth P., 1969, Lipid Chromatographic Analysis, 149

10.1021/ac60172a041

10.3181/00379727-130-33722

10.1007/BF02532632

10.1111/j.1748-1716.1957.tb01376.x

10.3891/acta.chem.scand.20-1297

Danielsson H., 1964, Ibid., 18, 732

Matin C., 1972, Masters' degree thesis

10.1126/science.179.4074.702

10.1016/S0022-2275(20)39435-9

10.1016/0021-9150(70)90042-0

10.1093/jn/79.4.523

10.1016/S0022-2275(20)39434-7

10.1172/JCI107145

Cooper R.A., 1972, J. Lab. Clin. Med., 79, 7

10.1016/S0022-2275(20)39368-8

Sardet C., 1972, Ibid., 13, 705

10.1172/JCI105775

Thông tin
Thông tin xuất bản

Lipids

Tập 9 Số 10

731-737

Thông tin tác giả