Effects of administration of hypolipidemic agent, 2,2′″‐[(1‐methyl‐4,4‐diphenylbutylidene)bis(p‐phenyleneoxy)] bistriethylamine oxalate (SQ 10,591) upon cholesterol esterification by aorta, adrenal, and testes of cholesterol‐fed rabbits

Lipids - 1975
Robert J. Morin1
1Department of Pathology, Harbor General Hospital, University of California at Los Angeles School of Medicine, Torrance, California, 90509

Tóm tắt

AbstractAdministration of 2,2′″‐([1‐methyl‐4,4‐diphenylbutylidene] bis(p‐phenyleneoxy]) bistriethylamine oxalate (SQ 10,591) at 20 mg/Kg daily for 5 days to cholesterol‐fed rabbits resulted in no change in aortic microsomal cholesterol esterification with a palmitoyl coenzyme A substrate or of aortic mitochondrial cholesterol esterification with a palmitate substrate. Esterification by both reactions in the adrenal was much higher than in either aorta or testes. Adrenal and testicular mitochondrial esterification and testicular microsomal esterification were inhibited significantly after SQ 10,591 administration. In vitro addition of 0.0001 M SQ 10,591 significantly inhibited both microsomal and mitochondrial cholesterol esterification in aorta, adrenal, and testes.

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Tài liệu tham khảo

10.1016/S0368-1319(68)80109-7

10.3181/00379727-138-35956

10.1016/S0368-1319(69)80007-4

Bowyer D.E., 1967, Biochem. J., 103, 54

10.1161/01.RES.27.2.213

10.1016/0005-2760(72)90020-3

10.1016/0021-9150(74)90076-8

10.1016/S0021-9258(18)64849-5

Lowry O.H., 1951, Ibid., 193, 165

10.1093/ajcn/23.9.1241

10.1002/jps.2600611003

10.1042/bj1320313

Rogers L.A., 1964, J. Pharmacol. Exptl. Ther., 146, 286

10.1111/j.2042-7158.1956.tb12123.x

10.1016/0006-2952(74)90013-6

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Lipids

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