Effects of Skin Occlusion on Percutaneous Absorption: An Overview

Skin Pharmacology and Physiology - Tập 14 Số 1 - Trang 1-10 - 2001
Hongbo Zhai1, Howard I. Maïbach1
1Department of Dermatology, University of California, School of Medicine, San Francisco, Calif., USA

Tóm tắt

Skin occlusion produces profound changes, including hydration status, barrier permeability, epidermal lipids, DNA synthesis, microbial flora, and numerous molecular and cellular processes. It often, but not always, increases percutaneous absorption of applied chemicals. This overview focuses on the effect of skin occlusion on percutaneous absorption.

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Tài liệu tham khảo

10.1002/(SICI)1097-0029(19981101)43:3<242::AID-JEMT6>3.0.CO;2-G

10.1001/archderm.111.1.33

10.1080/00015550252948293

10.1016/0022-4804(83)90136-1

10.1046/j.1523-1747.1998.00364.x

10.1159/000066243

10.1046/j.1523-1747.1999.00774.x

10.1111/1523-1747.ep12463284

10.1016/0278-6915(86)90007-4

10.1016/0278-6915(92)90056-Q

10.1016/0278-6915(92)90150-J

10.1016/0278-6915(85)90228-5

10.1006/taap.1993.1180

10.1016/0278-6915(90)90111-Y

10.1001/archderm.92.6.661