Effects of High-monounsaturated Fatty Acid Enteral Formula versus High-carbohydrate Enteral Formula on Plasma Glucose Concentration and Insulin Secretion in Healthy Individuals and Diabetic Patients

Journal of International Medical Research - Tập 36 Số 1 - Trang 137-146 - 2008
S. Zeidler1, YOSHIHISA SOMEYA1, Rie Yoshihara1, Hiroto Ishii1
1Division of Diabetes and Endocrinology, Department of Internal Medicine, Jikei Daisan University Hospital, Tokyo, Japan

Tóm tắt

We investigated the effects of high-monounsaturated fatty acid (MUFA) versus high-carbohydrate enteral formula on post-prandial plasma glucose concentration and insulin response in Japanese patients with type 2 diabetes mellitus and healthy Japanese volunteers. Ten healthy volunteers aged 20.8 ± 1.2 years and 12 diabetic patients with good glycaemic control (glycosylated haemoglobulin < 7%) aged 58.6 ± 7.7 years were randomly assigned to take high-MUFA or high-carbohydrate formula after a 12-h overnight fast. The patients switched to the other formula after 7 days. Post-prandial plasma glucose and insulin response were significantly lower in all subjects after taking high-MUFA formula compared with high-carbohydrate formula. No differences were observed in free fatty acids, triglycerides and plasma glucagon between the two diet groups. In conclusion, a high-MUFA enteral formula suppresses post-prandial hyperglycaemia without exaggerated insulin secretion compared with a high-carbohydrate enteral diet in patients with type 2 diabetes and healthy subjects.

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Thông tin xuất bản

Journal of International Medical Research

Tập 36 Số 1

137-146

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