Effects of Full‐Mouth Scaling and Root Planing in Conjunction With Systemically Administered Azithromycin

Journal of Periodontology - Tập 78 Số 3 - Trang 422-429 - 2007
Kazuhiro Gomi1, Akihiro Yashima1, Takatoshi Nagano1, Mikimoto Kanazashi1, Nobuko Maeda2, Takashi Arai1
1Department of Periodontics and Endodontics, Tsurumi University, School of Dental Medicine, Yokohama, Japan.
2Department of Oral Bacteriology, Tsurumi University, School of Dental Medicine.

Tóm tắt

Background: One‐stage full‐mouth disinfection (FMD), in which full‐mouth scaling and root planing (SRP) is performed with adjunctive use of chlorhexidine, was introduced in 1995. There have been several reports on the effectiveness of this treatment protocol. However, FMD was reported to induce pyrexia frequently. We examined the effects of full‐mouth SRP in conjunction with azithromycin administered orally before SRP to control the number of bacteria. The purpose of this study was to compare the effects of full‐mouth SRP using azithromycin with conventional SRP.Methods: Thirty‐four subjects (17 in the test group and 17 in the control group) with severe chronic periodontitis were selected. The subjects of the test group had azithromycin 3 days before full‐mouth SRP. Clinical parameters (probing depth [PD], gingival index [GI], bleeding on probing [BOP], and gingival crevicular fluid [GCF]), total number of bacteria, and number of black pigment‐producing rods (BPRs) were evaluated at baseline and 5, 13, and 25 weeks after baseline.Results: All clinical parameters improved in the test group more than in the control group. In the bacteriologic examination, the total number of bacteria did not change during the examination. In the test group, BPRs were not detected until 13 weeks. However, BPRs were detected in the control group by 13 weeks.Conclusion: It was shown that full‐mouth SRP using systemically administered azithromycin was a clinically and bacteriologically useful basic periodontal treatment for severe chronic periodontitis.

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Tài liệu tham khảo

10.1902/jop.1976.47.1.1

10.1111/j.1365-2710.1992.tb01220.x

10.1902/jop.1991.62.4.247

Russell RR, 1992, Bacteriology of periodontal disease, Curr Opin Dent, 2, 66

10.1038/sj.bdj.4807849

10.2329/perio.31.895

10.1111/j.1600-051X.1984.tb01323.x

Mousques T, 1980, Effect of scaling and root planing on the composition of human subgingival microbial flora, J Periodontal Res, 15, 114

Sumida S, 2002, Transmission of periodontal disease‐associated bacteria from teeth to osseointegrated implant regions, Int J Oral Maxillofac Implants, 17, 696

10.1177/00220345950740080501

10.1111/j.1600-051X.1998.tb02364.x

10.1006/anae.1997.0097

10.1902/jop.1996.67.12.1251

10.1111/j.0303-6979.2004.00462.x

10.1111/j.0303-6979.2004.00461.x

10.1902/jop.2002.73.7.797

10.1034/j.1600-051x.2000.027008578.x

10.1046/j.1365-3083.1996.d01-345.x

10.1128/AAC.33.3.277

10.1093/jac/25.suppl_A.73

10.1007/BF01975835

10.1016/0002-9343(91)90394-D

10.1902/jop.2007.060246

10.3109/00016356309011240

10.1111/j.1399-302X.1996.tb00180.x

10.1111/j.1600-0757.1999.tb00165.x

Takeda K, 2002, Quorum‐sensing system that modulates both bacterial virulence factor expression and host responses, Bacterial Adherence Biofilm, 16, 11

10.1111/j.1600-051X.1998.tb02356.x

10.1902/jop.2000.71.1.79

10.1034/j.1600-051x.2001.028004296.x

10.1034/j.1600-051x.2001.028007597.x

10.1111/j.1600-051X.2004.00573.x

10.1093/jac/31.suppl_E.5

10.1093/jac/25.suppl_A.39

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Journal of Periodontology

Tập 78 Số 3

422-429

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