Effects of Endocrine Therapy on Cognitive Function in Patients with Breast Cancer: A Comprehensive Review

Cancers - Tập 14 Số 4 - Trang 920
Lucy Haggstrom1, Janette Vardy2,3, Emma‐Kate Carson1,4, Davendra Segara5, Elgene Lim6,5, Belinda E. Kiely1,4,7
1Campbelltown Hospital, Therry Road, Campbelltown, NSW, 2560, Australia
2Concord Cancer Centre, Concord Repatriation and General Hospital, Concord, NSW 2139, Australia
3Faculty of Medicine and Health, University of Sydney, Camperdown, NSW 2006, Australia
4Concord Clinical School, University of Sydney, Concord, NSW 2139, Australia
5St Vincent’s Clinical School, University of New South Wales, Darlinghurst, NSW 2010, Australia
6Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia
7NHMRC Clinical Trials Centre, University of Sydney, Camperdown, NSW 2050, Australia

Tóm tắt

Endocrine therapy forms the backbone of systemic therapy for the majority of persons with early and late-stage breast cancer. However, the side effects can negatively affect quality of life, and impact treatment adherence and overall oncological outcomes. Adverse effects on cognition are common, underreported and challenging to manage. We aim to describe the nature, incidence, risk factors and underlying mechanisms of endocrine therapy-induced cognitive dysfunction. We conducted a comprehensive literature review of the studies reporting on cognitive dysfunction associated with endocrine therapies for breast cancer. We also summarise prevention and treatment strategies, and ongoing research. Given that patients are taking endocrine therapies for longer durations than ever before, it is essential that these side effects are managed pro-actively within a multi-disciplinary team in order to promote adherence to endocrine therapy and improve patients’ quality of life.

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