Effects of Chemical Cross-linkers on Caries-affected Dentin Bonding

SAGE Publications - Tập 88 Số 12 - Trang 1096-1100 - 2009
Georgia V. Macedo1,2,3, M. Yamauchi1,4,3, Ana K. Bedran‐Russo1,4,3
1Dental Research Center CB#7450, University of North Carolina at Chapel Hill, USA; and
2Department of Operative Dentistry, University of North Carolina at Chapel Hill, NC, USA
3Department of Restorative Dentistry, University of Illinois at Chicago, 801 South Paulina Street, Room 551, Chicago, IL 60612, USA
4Department of Operative Dentistry and

Tóm tắt

The achievement of a strong and stable bond between composite resin and dentin remains a challenge in restorative dentistry. Over the past two decades, dental materials have been substantially improved, with better handling and bonding characteristics. However, little attention has been paid to the contribution of collagen structure/stability to bond strength. We hypothesized that the induction of cross-linking in dentin collagen improves dentin collagen stability and bond strength. This study investigated the effects of glutaraldehyde-and grape seed extract-induced cross-linking on the dentin bond strengths of sound and caries-affected dentin, and on the stability of dentin collagen. Our results demonstrated that the application of chemical cross-linking agents to etched dentin prior to bonding procedures significantly enhanced the dentin bond strengths of caries-affected and sound dentin. Glutaraldehyde and grape seed extract significantly increased dentin collagen stability in sound and caries-affected dentin, likely via distinct mechanisms.

Từ khóa


Tài liệu tham khảo

Armstrong SR, Vargas MA, Fang Q, Laffoon JE (2003). Microtensile bond strength of a total-etch 3-step, total-etch 2-step, self-etch 2-step, and a self-etch 1-step dentin bonding system through 15-month water storage. J Adhes Dent 5:47–56.

Bedran-Russo AK, Pereira PN, Duarte WR, Drummond JL, Yamauchi M (2007). Application of crosslinkers to dentin collagen enhances the ultimate tensile strength. J Biomed Mater Res B Appl Biomater 80:268–272.

Bedran-Russo AK, Pashley DH, Agee K, Drummond JL, Miescke KJ (2008). Changes in stiffness of demineralized dentin following application of collagen crosslinkers. J Biomed Mater Res B Appl Biomater 86:330–334.

10.1016/j.dental.2007.02.009

10.1016/S0300-5712(03)00088-5

10.1016/S0142-9612(02)00412-X

10.3109/03008209009009810

De Munck J, Van Meerbeek B, Inoue S, Vargas M, Yoshida Y, Armstrong S, et al. (2003). Micro-tensile bond strength of one- and two-step self-etch adhesives to bur-cut enamel and dentin. Am J Dent 16:414–420.

10.1007/s10856-005-2609-2

Han B, Jaurequi J, Tang BW, Nimni ME (2003). Proanthocyanidin: a natural crosslinking reagent for stabilizing collagen matrices. J Biomed Mater Res A 65:118–124.

10.1016/j.chemosphere.2006.11.037

10.1016/0076-6879(74)31057-9

10.1016/S0300-5712(96)00065-6

10.1016/S0109-5641(00)00056-7

10.1111/j.1708-8240.1991.tb00985.x

10.1177/00220345950740100901

10.1042/bj1120609

10.3109/03009748309102002

10.1034/j.1600-0722.2001.00088.x

Southern LJ, Hughes H, Lawford PV, Clench MR, Manning NJ (2000). Glutaraldehyde-induced cross-links: a study of model compounds and commercial bioprosthetic valves. J Heart Valve Dis 9:241–248.

10.1002/(SICI)1097-4636(199911)47:2<116::AID-JBM2>3.0.CO;2-J

10.1159/000135671

Yamauchi M, Shiiba M (2002). Lysine hydroxylation and crosslinking of collagen. Methods Mol Biol 194:277–290.

Yamauchi M, Shiiba M (2008). Lysine hydroxylation and cross-linking of collagen. Methods Mol Biol 466:95–108.

10.1177/154405910208100811

10.4012/dmj.24.648