Effectiveness of Donor Natural Killer Cell Alloreactivity in Mismatched Hematopoietic Transplants

American Association for the Advancement of Science (AAAS) - Tập 295 Số 5562 - Trang 2097-2100 - 2002
Loredana Ruggeri1, Marusca Capanni1, Elena Urbani1, Katia Perruccio1, Warren D. Shlomchik2, Antonellá Tosti1, Sabrina Posati1, Daniela Rogaia1, Francesco Frassoni3, Franco Aversa1, Maria Paola Martelli1, Andrea Velardi1
1Department of Clinical and Experimental Medicine, Section of Hematology and Clinical Immunology, Perugia University School of Medicine, Perugia, Italy.
2Department of Medicine, Sections of Hematology and Oncology, Yale University School of Medicine, New Haven, CT 06520, USA.
3Department of Hematology, Ospedale San Martino, Genoa, Italy.

Tóm tắt

T cells that accompany allogeneic hematopoietic grafts for treating leukemia enhance engraftment and mediate the graft-versus-leukemia effect. Unfortunately, alloreactive T cells also cause graft-versus-host disease (GVHD). T cell depletion prevents GVHD but increases the risk of graft rejection and leukemic relapse. In human transplants, we show that donor-versus-recipient natural killer (NK)–cell alloreactivity could eliminate leukemia relapse and graft rejection and protect patients against GVHD. In mice, the pretransplant infusion of alloreactive NK cells obviated the need for high-intensity conditioning and reduced GVHD. NK cell alloreactivity may thus provide a powerful tool for enhancing the efficacy and safety of allogeneic hematopoietic transplantation.

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Tài liệu tham khảo

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We thank A. Santucci for statistical analyses L. Romani for critical review of the manuscript and G. Boyd for her essential role in manuscript editing. Supported by grants from the Italian Association for Cancer Research the Italian Ministry of Research and the Italian Ministry of Health and by a translational research grant from the Leukemia and Lymphoma Society. W.D.S. is supported by NIH grant number HL03979.

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American Association for the Advancement of Science (AAAS)

Tập 295 Số 5562

2097-2100

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