Effectiveness and safety of loop electrosurgical excision procedure in a low‐resource setting

International Journal of Gynecology & Obstetrics - Tập 103 - Trang 105-110 - 2008
Prabhakaran Rema1, Sambasivan Suchetha1, Somanathan Thara2, Jean Marie Fayette3, Ramani Wesley4, Rengaswamy Sankaranarayanan3
1Division of Surgical Oncology, Regional Cancer Centre, Medical College Campus, Trivandrum, India
2Division of Pathology, Regional Cancer Centre, Medical College Campus, Trivandrum, India
3Screening Group, International Agency for Research on Cancer, Lyon, France
4Division of Preventive Oncology, Regional Cancer Centre, Medical College Campus, Trivandrum, India

Tóm tắt

AbstractObjectiveTo evaluate the effectiveness and safety of the loop electrosurgical excision procedure (LEEP) to treat cervical intraepithelial neoplasia (CIN) in a low‐resource setting.MethodsWomen participating in a cervical screening study in India with histologically confirmed CIN unsuitable for cryotherapy were advised to undergo LEEP. One year after treatment the cervix was visually inspected with acetic acid, followed by colposcopy and biopsy taken from abnormal areas. Cure was defined as no clinical or histologic evidence of CIN. Factors influencing cure rates were evaluated by tests.ResultsOf the 311 women who underwent LEEP, 283 reported for 1‐year follow‐up and 248 (87.6%) were disease free. Cure rates were 93.0% for CIN 1, 85.5% for CIN 2, and 72.7% for CIN 3. Minor adverse effects were observed in 34 women and complications were seen in 5 women.ConclusionLEEP was associated with minimal complications and acceptable cure rates in a low‐resource setting, although women with larger lesions had lower cure rates.

Tài liệu tham khảo

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Thông tin xuất bản

International Journal of Gynecology & Obstetrics

Tập 103

105-110

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