Effect of zerumbone on scopolamine‐induced memory impairment and anxiety‐like behaviours in rats

Alzheimer's and Dementia: Translational Research and Clinical Interventions - Tập 5 - Trang 637-643 - 2019
Sahba Jafarian1, King-Hwa Ling1,2, Zurina Hassan3, Lua Perimal-Lewis4, Mohd Roslan Sulaiman1, Enoch Kumar Perimal1,5
1Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia
2Department of Genetics, Harvard Medical School, Boston, MA, USA
3Center for Drug Research, Universiti Sains Malaysia, Gelugor, Penang, Malaysia
4Flinders Digital Health Research Centre, College of Nursing and Health Sciences, Flinders University of South Australia, Adelaide, SA, Australia
5Australian Research Council Centre of Excellence for Nanoscale BioPhotonics, University of Adelaide, Adelaide, SA, Australia

Tóm tắt

AbstractIntroductionWe investigated the effects of zerumbone (1 and 10 mg/kg) against hyperactivity, anxiety and memory impairment in scopolamine‐induced dementia in Sprague‐Dawley rats.MethodsOpen field tests, elevated plus maze and Morris water maze were performed to assess general locomotor activity, anxiety‐like behaviours and learning and memory processes respectively in rats pretreated with scopolamine.ResultsScopolamine‐treated rats showed high total activity, stereotype, and total distance travelled in the open field arena, reduced number of entries to open arms, decreased the percentage of time spent in open arms and higher escape latency time in the Morris water maze test. Interestingly, single administration of zerumbone (1 and 10 mg/kg) reversed the hyperactivity, anxiety‐like behaviours, and learning impairment effects of scopolamine in the three experimental model studied respectively.DiscussionOur findings demonstrated that the scopolamine‐induced impairment of learning and memory was reversed by the administration of zerumbone. As a conclusion, our findings presented the positive effects of zerumbone on dementia‐like behaviours in the animal model used and could possibly contribute for future research to manage hyperactivity, anxiety, and learning disabilities.

Tài liệu tham khảo

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Alzheimer's and Dementia: Translational Research and Clinical Interventions

Tập 5

637-643

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