Effect of the Modified Live Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Vaccine on European and North American PRRSV Shedding in Semen from Infected Boars

American Society for Microbiology - Tập 18 Số 10 - Trang 1600-1607 - 2011
Kyu Young Han1, Hwi Won Seo2, Jeoung Hwa Shin3, Yeonsu Oh2, Ikjae Kang2, Changhoon Park2, Chanhee Chae2
1Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, 599 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea
21Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, 599 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea
32Korea Basic Science Institute, Environmental and Metabolomics Research Team, 126-16 Anam-dong, Seongbuk-gu, Seoul 136-713, Republic of Korea

Tóm tắt

ABSTRACTThe objective of the present study was to compare the effects of the modified live porcine reproductive and respiratory syndrome virus (PRRSV) vaccine (Ingelvac PRRS MLV; Boehringer Ingelheim Animal Health, St. Joseph, MO) on European and North American PRRSV shedding in the semen of experimentally infected boars. The boars were randomly divided into six groups. Vaccinated boars shed the North American PRRSV at the rate of 100.1to 101.0viral genome copies per ml and 3.63 to 101.150% tissue culture infective doses (TCID50)/ml, respectively, in semen, whereas nonvaccinated boars shed the North American PRRSV at the rate of 100.2to 104.7viral genome copies per ml and 1.14 to 103.07TCID50/ml, respectively, in semen. Vaccinated boars shed the European PRRSV at the rate of 100.1to 104.57viral genome copies per ml and 1.66 to 103.10TCID50/ml, respectively, in semen, whereas nonvaccinated boars shed the European PRRSV at the rate of 100.3to 105.14viral genome copies per ml and 1.69 to 103.17TCID50/ml, respectively, in semen. The number of genomic copies of the European PRRSV in semen samples was not significantly different between vaccinated and nonvaccinated challenged European PRRSV boars. The present study demonstrated that boar vaccination using commercial modified live PRRSV vaccine was able to decrease subsequent shedding of North American PRRSV in semen after challenge but was unable to decrease shedding of European PRRSV in semen after challenge.

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American Society for Microbiology

Tập 18 Số 10

1600-1607

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