Effect of paradoxical sleep deprivation on dna synthesis in fetal rat brain

International Journal of Developmental Neuroscience - Tập 2 - Trang 585-590 - 1984
G. Grassi-Zucconi1, S. Belia1, F. Franciolini1, E. Menichini1, A. Giuditta2
1Institute of Cell Biology, Perugia Via Marconi, 10, 80125 Naples, Italy
2Institute of General Physiology and International Institute of Genetics and Biophysics, Via Marconi, 10, 80125 Naples, Italy

Tóm tắt

Abstract

We have investigated the effect of PS‐D induced in gestating rats by treatment with clomipramine or with the platform technique on the process of DNA synthesis taking place in fetal organs. This parameter was taken as a biochemical index of ongoing cellular proliferation. In brain and, to a minor extent, in liver and kidney the rate of fetal DNA synthesis was markedly increased in both experimental groups. The effect was more prominent in the clomipramine group. PS‐D treatment of gestating rats, notably by the platform technique, left long‐lasting effects in the offspring with regard to organ weight and DNA concentration as well as to learning capacity. It is concluded that the occurrence of PS in gestating rats may exert a significant influence on fetal development.


Tài liệu tham khảo

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Thông tin xuất bản

International Journal of Developmental Neuroscience

Tập 2

585-590

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