Effect of myrtle fruit syrup on abnormal uterine bleeding: a randomized double-blind, placebo-controlled pilot study

DARU Journal of Pharmaceutical Sciences - Tập 22 Số 1 - 2014
Marzieh Qaraaty1, Seyed Hamid Kamali2, Fataneh Hashem Dabaghian3, Nafiseh Zafarghandi4, Roshanak Mokaberinejad5, Masumeh Mobli6, Gholamreza Amin6, Mohsen Naseri1, Mohammad Kamalinejad7, Mohsen Amin8, Azizeh Ghaseminejad9, Seyedeh jihan HosseiniKhabiri10, Daryush Talei11
1Traditional Medicine Clinical Trial Research Center, Shahed University, Tehran, Iran
2Department of Traditional Medicine, Faculty of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3Research Institute for Islamic and Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran
4Department of Gynecology and Obstetrics, Faculty of Medical Sciences, Shahed University, Tehran, Iran
5Department of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
6Department of Traditional Pharmacy, Faculty of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran
7Department of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
8Department of Drug and Food Control, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
9Department of Gynecology and Obstetrics, Tehran University of Medical Sciences, Tehran, Iran
10Khatam Hospital, Tehran, Iran
11Medicinal Plant Research Centre, Shahed University, Tehran, Iran

Tóm tắt

Abstract Background Myrtle (Myrtus communis L.) has been used in the Iranian Traditional Medicine as a treatment for abnormal uterine bleeding-menometrorrhagia. The main aim of this study is to evaluate the effect of myrtle fruit syrup on abnormal uterine bleeding-menometrorrhagia. Methods A randomized, double-blind, placebo-controlled pilot study was conducted on 30 women suffering from abnormal uterine bleeding-menometrorrhagia. Treatment comprised of giving 15 ml oral myrtle syrup daily (5 ml three times a day) for 7 days starting from the onset of bleeding. The myrtle syrup along with placebo was repeated for 3 consecutive menstrual periods. Menstrual duration and number of used pads were recorded by the Pictorial Blood loss Assessment Chart at the end of each menstrual period. The quality of life was also evaluated using the menorrhagia questionnaire. Results The mean number of bleeding days significantly declined from 10.6 ± 2.7 days to 8.2 ± 1.9 days after 3 months treatment with the syrup (p = 0.01) and consequently the participants in the intervention group used fewer pads after 3 months (16.4 ± 10.7) compared with the number of pads used at the beginning of the treatment (22.7 ± 12.0, p = 0.01). Bleeding days and number of pads used by the participants in the placebo group did not change significantly. Also significant changes of quality of life scores were observed in the intervention group after 3 months compared to the baseline. Conclusion Myrtle syrup is introduced as a potential remedy for abnormal uterine bleeding-menometrorrhagia.

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Tài liệu tham khảo

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DARU Journal of Pharmaceutical Sciences

Tập 22 Số 1

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