Effect of Lactobacillus plantarum P‐8 on lipid metabolism in hyperlipidemic rat model

European Journal of Lipid Science and Technology - Tập 114 Số 11 - Trang 1230-1236 - 2012
Yan Bao1, Zhanli Wang2, Yong Zhang1, Jiachao Zhang1, Lifeng Wang1, Ximei Dong1, Fang Su1, Guoqiang Yao1, Shuiquan Wang1, Heping Zhang1
1The Key Laboratory of Dairy Biotechnology and Bioengineering, Department of Food Science and Engineering, Education Ministry of P. R. China, Inner Mongolia Agricultural University, Huhhot, P. R. China
2The First Affiliated Hospital, Medical College of Baotou, Baotou, P. R. China

Tóm tắt

AbstractProbiotics have been reported to play an important role in the prevention of metabolic disorders. We recently identified a novel probiotic strain Lactobacillus plantarum (L. plantarum) P‐8. The objective of this study was to determine the effects of L. plantarum P‐8 on lipid metabolism of rats fed with high fat diet. All experimental rats were divided into three groups: control group, model group, and L. plantarum P‐8 group. Changes in serum lipid levels, hepatic lipid deposition, serum oxidative stress‐related parameters, activities of liver function marker enzymes, organ indices, gut microflora, and fecal lipids were assessed. Compared with model group, L. plantarum P‐8 exhibited hypolipidemic effects by lowering serum total cholesterol (TC), triglyceride (TG), and low‐density lipoprotein cholesterol levels, accompanied with elevation of high‐density lipoprotein cholesterol level. L. plantarum P‐8 also exerted beneficial effects against high‐fat diet‐induced oxidative stress, curtailed the accumulation of liver lipids and protected healthy liver function. Moreover, L. plantarum P‐8 was able to regulate intestinal bacteria and enhance the fecal excretion of TC, TG, and bile acid. These findings indicate that L. plantarum P‐8 may represent a potential therapeutic agent for controlling hyperlipidemia.

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Thông tin xuất bản

European Journal of Lipid Science and Technology

Tập 114 Số 11

1230-1236

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