Effect of halothane on myocardial infarct size in rats

Canadian Journal of Anaesthesia - Tập 28 - Trang 239-243 - 1981
Igor Kissin1, Rex Stanbridge2, Sanford P. Bishop3, J. G. Reves1
1Department of Anesthesiology, School of Medicine, University of Alabama, Birmingham, USA
2Department of Surgery, School of Medicine, University of Alabama, Birmingham, USA
3Department of Pathology, School of Medicine, University of Alabama, Birmingham, USA

Tóm tắt

The effect of halothane on myocardial infarction caused by ligation of the left descending coronary artery was studied in rats. The extent of infarction was quantified 48 hours after ligation of the artery by planimetric measurement of left ventricular slices stained with nitrobluetetrazolium. Animals exposed to halothane one per cent for three hours after the coronary ligation were compared with a control group which received halothane for only 5-7 minutes during surgery. It was found that halothane caused a small increase in infarction size (31.3 ± 1.5 per cent of the left ventricle compared to 25.7 ± 2.3 percent, p < 0.05). This effect was accompanied by a decrease in systolic blood pressure (91 ± 2 mmHg compared to 113 ± 3 mm Hg, p < 0.001). Heart rate did not change significantly. Analysis of our results in comparison to previously reported data on the effect of halothane on myocardial ischaemia in different experimental conditions shows that halothane may produce beneficial as well as detrimental effects on ischaemic injury to the myocardium. The latter can result when the drug causes marked hypotension in the absence of a significant decrease in heart rate.

Tài liệu tham khảo

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Canadian Journal of Anaesthesia

Tập 28

239-243

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