Effect of doxorubicin on fibroblast migration and proliferation

Annals of Ophthalmology - Tập 35 - Trang 48-52 - 2003
L. Izaguirre1, I. Pinilla1, F. Gonzalvo1, S. Pérez1, F. M. Honrubia1
1Department of Ophthalmology, Miguel Servet Hospital, Zaragoz, Spain

Tóm tắt

This study evaluated the effect of doxorubicin on fibroblast migration and proliferation. An artificial wound was made in a fibroblast monolayer, and doxorubicin was added. The cell-free area was monitored. Viability and proliferation were assessed by the cell proliferation reagent WST-1. Doxorubicin at 10−6M or greater inhibited migration. Proliferation was decreased with 2.5×10−5 or more of doxorubicin. Doses at 5×10−5M and at 10−4M showed cellular toxicity. Doxorubicin effectively inhibits wound repair.

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Annals of Ophthalmology

Tập 35

48-52

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