Effect of citalopram (Lu 10-171) on tranylcypromine and tryptophan-induced wet-dog shakes in rats

Psychopharmacology - Tập 70 - Trang 209-212 - 1980
Hiremagulur J. Hrishi Keshavan1, Nirmal K. Gurbani1, Prem C. Dandiya2
1Department of Pharmacology, S.M.S. Medical College, Jaipur, India
2Faculty of Medicine, Al-Fateh University, Tripoli, Libya

Tóm tắt

It has been found that citalopram (Lu 10-171) has profound effects on serotonin (5-HT) metabolism by increasing the 5-HT levels in the cerebellum, medulla, and the whole brain with a corresponding decrease of the 5-HIAA levels in all parts of the brain except the brain stem. On the other hand, the drug does not appear to have any influence on the wet-dog shakes response induced by the combination of a monoamine oxidase inhibitor (MAOI) and l-tryptophan. It is suggested that by increasing the neuronal levels of 5-HT, citalopram decreases the turnover of 5-HT and firing rate of serotonin neurons. It has also been observed that citalopram could be an agonist of a certain type of 5-HT receptor which does not respond to the behavioral screening model proposed by Bedard and Pycock (1977).

Tài liệu tham khảo

Bedard P, Pycock CJ (1977) Wet dog shake behaviour in the rat: a possible quantitative model of central 5-HT activity. Neuropharmacology 16:663–670

Carlsson A, Corrodi H, Fuxe K, Hokfelt T (1969a) Effect of antidepressant drugs on the depletion of intraneuronal brain 5-HT stores caused by 4-methyl-alpha-ethyl-meta-tyramine. Eur J Pharmacol 5:357–366

Carlsson A, Corrodi H, Fuxe K, Hokfelt T (1969 b) Effect of some antidepressant drugs on the depletion of intraneuronal catecholamine stores caused by 4-alpha-dimethyl-metatyramine. Eur J Pharmacol 5:367–373

Fozard JR, Palfreyman MK (1979) Metoclopramide antagonism of 5-HT induced wet dog shakes behaviour in the rat. Arch Pharmacol 307:135–142

Grahame-Smith DG (1971) Studies in vivo on the relationship between brain tryptophan, brain 5-HT synthesis and hyperactivity in rat treated with a monoamine oxidase inhibitor and l-tryptophan. J Neurochem 18:1053–1066

Haubrich DR, Denzer JS (1973) Simultneous extraction and fluorometric measurement of brain 5-HT, 5-HIAA, CA's and HVA. Anal Biochem 55:306–312

Hyttel J (1977 a) Neurochemical characterisation of a new potent and selective uptake inhibitor Lu 10-171. Psychopharmacology 51:225–233

Hyttel J (1977 b) Effect of a selective 5-HT uptake inhibitor —Lu 10-171. Acta Pharmacol Toxicol (Kbh) 40:439–446

Jacoby JH, Poulakos JJ, Bryce GF (1978) On the central antiserotoninergic actions of cyproheptadine and methysergide. Neuropharmacology 17:299–306

Kielhoz P, Poldinger W (1968 a) Die Behandlung endogener Depressionen mit Psychopharmaka. Dtsch Med Wochenschr 174:701–704

Kielhoz P, Poldinger W (1968 b) Pharmacotherapy of endogenous depression. Compr Psychiatry 9:179–186

Lapin IP, Oxenkrug GP (1969) Intensification of the central serotonergic processes as a possible determinant of thymoleptic effect. Lancet I:132–136

Schildkraut JJ (1965) The catecholamine hypothesis of affective disorders: a review of supporting evidence. Am J Physiol 122:509–522

Schildkraut JJ (1973) Neuropharmacology of affective disorders. Ann Rev Pharmacol 13:427–454

Thông tin
Thông tin xuất bản

Psychopharmacology

Tập 70

209-212

Thông tin tác giả