Effect of Substance P on Pulmonary Resistance and Dynamic Pulmonary Compliance in the Anaesthetized Cat and Guinea‐pig

Wiley - Tập 41 Số 5 - Trang 444-448 - 1977
Paul Andersson1, Håkan Persson1
1From AB Draco (subsidiary to AB Astra, Sweden), Research and Development Laboratories, Fack, S‐221 01 Lund, Sweden

Tóm tắt

Abstract The effect of substance P, acetylcholine, and histamine on pulmonary resistance (RL) and on pulmonary dynamic compliance (CDYN) was studied in the anaesthetized cat and guinea‐pig. In the anaesthetized guinea‐pig, substance P (0.1‐1.0 üg/kg), acetylcholine (1.0‐10 μg/kg), and histamine (1.0‐10.0 μg/kg) produced a dose‐dependent increase in RL and decrease in CDYN. In the anaesthetized cat, the effect of substance P was weak on both RL and CDYN, whereas histamine (5‐50 μg/kg) produced a dose‐dependent increase in CDYN, but the effect on RL was weak. The effect of acetylcholine was qualitatively the same as in the anaesthetized guina‐pig but about 10 times less effective.

Từ khóa


Tài liệu tham khảo

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Thông tin
Thông tin xuất bản

Wiley

Tập 41 Số 5

444-448

Thông tin tác giả