Effect of Naturally Occurring Ozone Air Pollution Episodes on Pulmonary Oxidative Stress and Inflammation

International Journal of Environmental Research and Public Health - Tập 12 Số 5 - Trang 5061-5075
C.S. Pirozzi1, Anne Sturrock1, Hsin‐Yi Weng2, Tom Greene3, Mary Beth Scholand1, Richard E. Kanner1, Robert III1
1Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Utah, 26 North 1900 East, Salt Lake City, UT 84132, USA
2Department of Pediatrics, University of Utah, Salt Lake City, UT 84132, USA
3Department of Internal Medicine, Division of Epidemiology, University of Utah, Salt Lake City, UT 84132, USA

Tóm tắt

This study aimed to determine if naturally occurring episodes of ozone air pollution in the Salt Lake Valley in Utah, USA, during the summer are associated with increased pulmonary inflammation and oxidative stress, increased respiratory symptoms, and decreased lung function in individuals with chronic obstructive pulmonary disease (COPD) compared to controls. We measured biomarkers (nitrite/nitrate (NOx), 8-isoprostane) in exhaled breath condensate (EBC), spirometry, and respiratory symptoms in 11 former smokers with moderate-to-severe COPD and nine former smokers without airflow obstruction during periods of low and high ozone air pollution. High ozone levels were associated with increased NOx in EBC in both COPD (8.7 (±8.5) vs. 28.6 (±17.6) μmol/L on clean air vs. pollution days, respectively, p < 0.01) and control participants (7.6 (±16.5) vs. 28.5 (±15.6) μmol/L on clean air vs. pollution days, respectively, p = 0.02). There was no difference in pollution effect between COPD and control groups, and no difference in EBC 8-isoprostane, pulmonary function, or respiratory symptoms between clean air and pollution days in either group. Former smokers both with and without airflow obstruction developed airway oxidative stress and inflammation in association with ozone air pollution episodes.

Từ khóa


Tài liệu tham khảo

Jerrett, 2009, Long-term ozone exposure and mortality, N. Engl. J. Med., 360, 1085, 10.1056/NEJMoa0803894

Zanobetti, 2011, Ozone and survival in four cohorts with potentially predisposing diseases, Am. J. Respir. Crit. Care Med., 184, 836, 10.1164/rccm.201102-0227OC

Rice, 2013, Short-term exposure to air pollution and lung function in the framingham heart study, Am. J. Respir. Crit. Care Med., 188, 1351, 10.1164/rccm.201308-1414OC

2006, The effect of ozone and PM10 on hospital admissions for pneumonia and chronic obstructive pulmonary disease: A national multicity study, Am. J. Epidemiol., 163, 579, 10.1093/aje/kwj078

Ko, 2007, Temporal relationship between air pollutants and hospital admissions for chronic obstructive pulmonary disease in Hong Kong, Thorax, 62, 780, 10.1136/thx.2006.076166

Halonen, 2010, Ozone and cause-specific cardiorespiratory morbidity and mortality, J. Epidemiol. Community Health, 64, 814, 10.1136/jech.2009.087106

Arbex, 2009, Urban air pollution and chronic obstructive pulmonary disease-related emergency department visits, J. Epidemiol. Community Health, 63, 777, 10.1136/jech.2008.078360

Lee, 2009, Oxidative stress in COPD and Its measurement through exhaled breath condensate, Clin. Transl. Sci., 2, 150, 10.1111/j.1752-8062.2009.00093.x

Yang, 2009, Air pollutants, oxidative stress and human health, Mutat. Res./Genet. Toxicol. Environ. Mutagen., 674, 45, 10.1016/j.mrgentox.2008.10.005

Zatloukal, 2010, Nitrite in exhaled breath condensate as a marker of nitrossative stress in the airways of patients with asthma, COPD, and idiopathic pulmonary fibrosis, J. Clin. Lab. Anal., 24, 317, 10.1002/jcla.20408

Gessner, 2007, Breath condensate nitrite correlates with hyperinflation in chronic obstructive pulmonary disease, Respir. Med., 101, 2271, 10.1016/j.rmed.2007.06.024

Kostikas, 2003, Oxidative stress in expired breath condensate of patients with COPD, Chest, 124, 1373, 10.1378/chest.124.4.1373

Biernacki, 2003, Increased leukotriene B4 and 8-isoprostane in exhaled breath condensate of patients with exacerbations of COPD, Thorax, 58, 294, 10.1136/thorax.58.4.294

Huang, 2012, Inflammatory and oxidative stress responses of healthy young adults to changes in air quality during the Beijing Olympics, Am. J. Respir. Crit. Care Med., 186, 1150, 10.1164/rccm.201205-0850OC

Manney, 2012, Association between exhaled breath condensate nitrate + nitrite levels with ambient coarse particle exposure in subjects with airways disease, Occup. Environ. Med., 69, 663, 10.1136/oemed-2011-100255

Morris, A.H., Kanner, R.E., Crapo, R.O., and Gardner, R.M. (1984). Clinical Pulmonary Function Testing: A Manual of Uniform Laboratory Procedures, Intermountain Thoracic Society.

Hurst, 2010, Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) investigators: Susceptibility to exacerbation in chronic obstructive pulmonary disease, N Engl J Med, 363, 1128, 10.1056/NEJMoa0909883

Utah DEQ: DAQ, Available online:http://www.airquality.utah.gov.

Faustini, 2012, Short-term effects of air pollution in a cohort of patients with chronic obstructive pulmonary disease, Epidemiology, 23, 861, 10.1097/EDE.0b013e31826767c2

Bell, 2004, Ozone and short-term mortality in 95 US urban communities, 1987–2000, JAMA, 292, 2372, 10.1001/jama.292.19.2372

Gold, 1999, Particulate and ozone pollutant effects on the respiratory function of children in southwest Mexico City, Epidemiology, 10, 8, 10.1097/00001648-199901000-00004

Higgins, 1995, Effects of air pollution on symptoms and peak expiratory flow measurements in subjects with obstructive airways disease, Thorax, 50, 149, 10.1136/thx.50.2.149

Respiratory Research. Available online:http://www.respiratoryresearch.com.

Verbeke, G., and Molenberghs, G. (2009). Linear Mixed Models for Longitudinal Data, Springer Science & Business Media.

Alfaro, 2007, Breath condensate levels of 8-isoprostane and leukotriene B4 after ozone inhalation are greater in sensitive versus nonsensitive subjects, Exp. Lung Res., 33, 115, 10.1080/01902140701364367

Nightingale, 1999, Effect of inhaled ozone on exhaled nitric oxide, pulmonary function, and induced sputum in normal and asthmatic subjects, Thorax, 54, 1061, 10.1136/thx.54.12.1061

Nightingale, 2000, No effect of inhaled budesonide on the response to inhaled ozone in normal subjects, Am. J. Respir. Crit. Care Med., 161, 479, 10.1164/ajrccm.161.2.9905031

Sunyer, 2008, Air Pollution, airway inflammation, and lung function in a cohort study of Mexico city schoolchildren, Environ. Health Perspect., 116, 832, 10.1289/ehp.10926

Liu, 2009, Acute effects of air pollution on pulmonary function, airway inflammation, and oxidative stress in asthmatic children, Environ. Health Perspect., 117, 668, 10.1289/ehp.11813

Ito, 2005, Associations between ozone and daily mortality: Analysis and meta-analysis, Epidemiology, 16, 446, 10.1097/01.ede.0000165821.90114.7f

Levy, 2005, Ozone exposure and mortality: An empiric bayes metaregression analysis, Epidemiology, 16, 458, 10.1097/01.ede.0000165820.08301.b3

Zanobetti, 2008, Mortality displacement in the association of ozone with mortality: An analysis of 48 cities in the United States, Am. J. Respir. Crit. Care Med., 177, 184, 10.1164/rccm.200706-823OC

Peng, 2013, Acute effects of ambient ozone on mortality in Europe and North America: Results from the APHENA study, Air Qual. Atmos. Health, 6, 445, 10.1007/s11869-012-0180-9

Schwartz, 2008, Who is more vulnerable to die from ozone air pollution?, Epidemiology, 19, 672, 10.1097/EDE.0b013e3181773476

Sunyer, 2001, Particles, and not gases, are associated with the risk of death in patients with chronic obstructive pulmonary disease, Int. J. Epidemiol., 30, 1138, 10.1093/ije/30.5.1138

Liu, 2007, Nitric oxide and exhaled breath nitrite/nitrates in chronic obstructive pulmonary disease patients, Respiration, 74, 617, 10.1159/000106379

Peacock, 2011, Outdoor air pollution and respiratory health in patients with COPD, Thorax, 66, 591, 10.1136/thx.2010.155358

Thông tin
Thông tin xuất bản

International Journal of Environmental Research and Public Health

Tập 12 Số 5

5061-5075

Thông tin tác giả