Effect of BNP on renal hemodynamics, tubular function and vasoactive hormones in humans

American Journal of Physiology - Renal Physiology - Tập 274 Số 1 - Trang F63-F72 - 1998
Kimmo Jensen1, Jan Carstens1, E. B. Pedersen1
1Research Laboratory of Nephrology and Hypertension, Aarhus University Hospital, DK-8000 Aarhus, Denmark

Tóm tắt

The effect of a continuous infusion of human brain natriuretic peptide (BNP) was studied in 48 healthy men. The study was randomized, placebo controlled, and single blind. BNP was given in doses of 1, 2, or 4 pmol ⋅ kg−1⋅ min−1for 60 min, and peak values of BNP in plasma were 38, 85, and 199 pmol/l, giving increments in plasma as seen in heart or renal failure. BNP infusion increased the urinary flow rate and the excretion of sodium in a dose-dependent way. The maximal effects were +65 and +156%, respectively. GFR increased and RPF decreased, the latter in a dose-dependent manner. Blood pressure, heart rate, angiotensin II, and aldosterone were all unaffected by infusion of BNP, whereas a direct inhibition of renin secretion was seen. With the use of the lithium clearance technique, we concluded that the tubular site of action is in both the proximal and distal segments, and the major effect on sodium handling is in the distal parts of the nephron.

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American Journal of Physiology - Renal Physiology

Tập 274 Số 1

F63-F72

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