Education and Dementia: A Meta-Analytic Study

Neuroepidemiology - Tập 26 Số 4 - Trang 226-232 - 2006
Francisco Caamaño‐Isorna1, Montserrat Corral2, Agustín Montes1, Bahi Takkouche1
1Department of Public Health, Faculty of Medicine, and
2Department of Clinical Psychology and Psychobiology, Faculty of Psychology, University of Santiago de Compostela, Santiago de Compostela, Spain

Tóm tắt

Considerable controversy exists about the role of education in the risk of dementia. Individual studies have not been conclusive so far. To examine the hypothesis that lower education is associated with a higher risk of dementia, we carried out a meta-analysis. Observational studies published as of October 2005 that examined the association between education and risk of dementia were systematically reviewed. Relative risks (RRs) and odds ratios were extracted from cohort and case-control studies. We first compared the risk of dementia in subjects with high level of education with the risk of dementia in those with low educational level. In a subsequent analysis, we compared the risk of persons with high education with the risk of subjects with education level other than high (medium, low). We weighted log RRs for cohort studies or odds ratios by the inverse of their variances. Nineteen studies were included in our meta-analysis (13 cohort and 6 case-control studies). RRs for low versus high education level were: Alzheimer’s disease (AD) 1.80 (95% CI: 1.43–2.27); non-AD dementias, 1.32 (95% CI: 0.92–1.88), and all dementias 1.59 (95% CI: 1.26–2.01). For low and medium versus high education level, the RRs were: AD 1.44 (95% CI: 1.24–1.67); non-AD 1.23 (95% CI: 0.94–1.61), and all dementias 1.33 (95% CI: 1.15–1.54). These results confirm that low education may be a risk factor for dementia, especially for AD.

Từ khóa


Tài liệu tham khảo

10.1136%2Fjnnp.66.2.177

10.1001%2Fjama.271.13.1004

10.1002%2Fana.410270412

10.1212%2FWNL.43.1_Part_1.13

10.1037%2F%2F0894-4105.7.3.273

10.1017%2FS1355617702813248

10.1016%2Fj.mam.2004.02.011

10.1212%2FWNL.34.7.939

10.1016%2FS0169-2607%2800%2900087-0

10.1111%2Fj.1600-0447.1991.tb07373.x

10.1212%2FWNL.45.9.1707

10.1016%2FS0895-4356%2897%2900121-2

10.1212%2FWNL.57.12.2236

10.1001%2Farchneur.59.11.1737

10.1046%2Fj.1532-5415.2002.50006.x

10.1080%2F1360786031000120750

10.1093%2Faje%2Fkwh018

10.1159%2F000109785

10.1093%2Faje%2Fkwf074

10.1097%2F00002093-200307000-00003

10.1002%2Fana.410230206

10.1212%2F01.WNL.0000069923.64550.9F

10.1002%2Fana.410320311

10.1002%2Fana.410370508

Thông tin
Thông tin xuất bản

Neuroepidemiology

Tập 26 Số 4

226-232

Thông tin tác giả