Các Nghiên Cứu Kinh Tế Về Bệnh Không Truyền Nhiễm và Chấn Thương Tại Ấn Độ: Một Tổng Quan Hệ Thống

Springer Science and Business Media LLC - Tập 16 - Trang 303-315 - 2018
Indrani Gupta1, Arjun Roy1
1Institute of Economic Growth, University of Delhi Enclave, Delhi, India

Tóm tắt

Gánh nặng từ các bệnh không truyền nhiễm và chấn thương (NCDI) tại Ấn Độ đang gia tăng nhanh chóng. Với sự đầu tư thấp của khu vực công vào lĩnh vực sức khỏe nói chung và gánh nặng tài chính cao cho các hộ gia đình trong việc điều trị, điều quan trọng là cần sử dụng các chứng cứ kinh tế để xác lập các ưu tiên trong bối cảnh NCDI. Mục tiêu của chúng tôi là hiểu mức độ sử dụng phân tích kinh tế tại Ấn Độ để (1) phân tích tác động của NCDI và (2) đánh giá các can thiệp phòng ngừa và điều trị. Phân tích này đặc biệt tập trung vào loại phân tích kinh tế sử dụng, các loại bệnh, mô hình tài trợ, quyền tác giả và đặc điểm của tác giả. Chúng tôi đã thực hiện một đánh giá hệ thống dựa trên các từ khóa kinh tế để xác định các nghiên cứu về NCDI tại Ấn Độ được công bố bằng tiếng Anh từ tháng 1 năm 2006 đến tháng 11 năm 2016. Tổng cộng, có 96 nghiên cứu đã được đưa vào đánh giá. Phân tích đã sử dụng thống kê mô tả, bao gồm tần suất và tỷ lệ phần trăm. Phần lớn các nghiên cứu là nghiên cứu tác động kinh tế, tiếp theo là các nghiên cứu đánh giá kinh tế, đặc biệt là phân tích chi phí - hiệu quả. Trong danh mục đánh giá chi phí/đánh giá kinh tế một phần, hầu hết là các nghiên cứu mô tả chi phí và phân tích chi phí. Dưới danh mục tác động kinh tế/gánh nặng kinh tế, phần lớn các nghiên cứu đã điều tra chi tiêu trực tiếp từ túi. Các nghiên cứu chủ yếu tập trung vào bệnh tim mạch, tiểu đường và khối u. Hơi hơn một nửa số nghiên cứu được tài trợ, với nguồn tài trợ chủ yếu đến từ bên ngoài Ấn Độ. Một nửa số nghiên cứu do các tác giả trong nước dẫn dắt. Trong hầu hết các nghiên cứu, tác giả chính là một chuyên gia lâm sàng hoặc một chuyên gia y tế công cộng; tuy nhiên, hầu hết các nghiên cứu do các nhà kinh tế dẫn dắt đều có tác giả đến từ bên ngoài Ấn Độ. Các kết quả chỉ ra sự thiếu tham gia của các nhà kinh tế nói chung và các nhà kinh tế y tế nói riêng trong nghiên cứu về NCDI tại Ấn Độ. Nhu cầu từ các nhà lập chính sách y tế về việc ra quyết định dựa trên bằng chứng dường như là thiếu hụt, điều này càng củng cố sự phân kỳ giữa kinh tế và chính sách y tế, và làm nổi bật nhu cầu ưu tiên các nguồn lực khan hiếm dựa trên bằng chứng về những gì hiệu quả. Việc xây dựng năng lực trong kinh tế y tế cần được chú trọng, và sự hỗ trợ của chính phủ cho điều này là cần thiết.

Từ khóa

#bệnh không truyền nhiễm #chấn thương #Ấn Độ #phân tích kinh tế #đánh giá kinh tế

Tài liệu tham khảo

World Health Organization. Noncommunicable diseases country profiles 2014. http://apps.who.int/iris/bitstream/10665/128038/1/9789241507509_eng.pdf. Accessed 2 May 2017. World Health Organization. India NCD Country Profile 2014. http://www.who.int/nmh/countries/ind_en.pdf. Accessed 2 May 2017. Reddy KS, et al. Responding to the threat of chronic diseases in India. Lancet. 2005;366(9498):1744–9. Selvaraj S, Abrol D, Gopakumar K. Access to medicines in India. New Delhi: Academic Foundation; 2014. World Health Organization. General government expenditure on health (GGHE) as % of THE. Global Health Expenditure Database 2012. http://apps.who.int/nha/ database/Select/Indicators/en. Accessed 2 May 2017. Government of India. Ministry of Health and Family Welfare. National Health Accounts Estimates for India, 2014–15. https://mohfw.gov.in/sites/default/files/National%20Health%20Accounts%20Estimates%20Report%202014-15.pdf. Accessed 7 Mar 2018. Jamison DT, Breman JG, Measham AR, et al., editors. Disease control priorities in developing countries. 2nd ed. Washington (DC): The International Bank for Reconstruction and Development / The World Bank; 2006 (Co-published by Oxford University Press, New York). Available from: https://www.ncbi.nlm.nih.gov/books/NBK11728/. Raftery J, Powell J. Health technology assessment in the UK. Lancet. 2013;382:1278–85. Downey LE, Mehndiratta A, Grover A, Gauba V, Sheikh K, Prinja S, Singh R, Cluzeau FA, Dabak S, Teerawattananon Y, Kumar S, Swaminathan S. Institutionalising health technology assessment: establishing the Medical Technology Assessment Board in India. BMJ Glob Health. 2017;2(2):e000259. https://doi.org/10.1136/bmjgh-2016-000259. Centers for Disease Control and Prevention. Public health economics and tools. 2017. https://www.cdc.gov/stltpublichealth/pheconomics/. Accessed 4 Nov 2017. Vos T, et al. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2013; 2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2015;388(10053):1545–602. Drummond MF, Sculpher MJ, Claxton K, Stoddart GL, Torrance GW. Methods for the economic evaluation of health care programmes. Oxford: Oxford University Press; 2015. Aggarwal K, et al. Comparison of clinical and cost-effectiveness of psoralen + ultraviolet A versus psoralen + sunlight in the treatment of chronic plaque psoriasis in a developing economy. Int J Dermatol. 2013;52(4):478–85. Ahmad A, et al. A comparison of enoxaparin with unfractionated heparins in patients with coronary heart disease in an emergency department in rural South Indian tertiary care teaching hospital. Indian J Pharmacol. 2015;47(1):90–4. Ahuja RB, Goswami P. Cost of providing inpatient burn care in a tertiary, teaching, hospital of North India. Burns. 2013;39(4):558–64. Alam K, Mahal A. The economic burden of angina on households in South Asia. BMC Public Health. 2014;14:179. Anchala R, et al. Evaluation of effectiveness and cost-effectiveness of a clinical decision support system in managing hypertension in resource constrained primary health care settings: results from a cluster randomized trial. J Am Heart Assoc. 2015;4(1):e001213. Basu S, et al. Palm oil taxes and cardiovascular disease mortality in India: economic-epidemiologic model. BMJ. 2013;347:f6048. Basu S, Bendavid E, Sood N. Health and economic implications of national treatment coverage for cardiovascular disease in india: cost-effectiveness analysis. Circ Cardiovasc Qual Outcomes. 2015;8(6):541–51. Basu S, et al. Averting obesity and type 2 diabetes in India through sugar-sweetened beverage taxation: an economic-epidemiologic modeling study. PLoS Med. 2014;11(1):e1001582. Basu S, Yudkin JS, Sussman JB, Millett C, Hayward RA. Alternative strategies to achieve cardiovascular mortality goals in China and India: a microsimulation of target- versus risk-based blood pressure treatment. Circulation. 2016;133(9):840–8. Burke MJ, Shenton RC, Taylor MJ. The economics of screening infants at risk of hearing impairment: an international analysis. Int J Pediatr Otorhinolaryngol. 2012;76(2):212–8. Buttorff C, et al. Economic evaluation of a task-shifting intervention for common mental disorders in India. Bull World Health Org. 2012;90(11):813–21. Campbell A, et al. Scalable, sustainable cost-effective surgical care: a model for safety and quality in the developing world, part II: program development and quality care. J Craniofac Surg. 2014;25(5):1680–4. Cecchini M, et al. Tackling of unhealthy diets, physical inactivity, and obesity: health effects and cost-effectiveness. Lancet. 2010;376(9754):1775–84. Chemmanam T, et al. A prospective study on the cost-effective utilization of long-term inpatient video-EEG monitoring in a developing country. J Clin Neurophysiol. 2009;26(2):123–8. Chisholm D, et al. Estimating the cost of implementing district mental healthcare plans in five low- and middle-income countries: the PRIME study. Br J Psychiatry. 2016;208(Suppl 56):s71–8. Daivadanam M, et al. Catastrophic health expenditure and coping strategies associated with acute coronary syndrome in Kerala, India. Indian J Med Res. 2012;136(4):585–92. Das K, et al. Evaluation of socio-economic factors causing discontinuation of epilepsy treatment resulting in seizure recurrence: a study in an urban epilepsy clinic in India. Seizure. 2007;16(7):601–7. Das K, et al. Discontinuation of secondary preventive treatment of stroke: an unexplored scenario in India. Clin Neurol Neurosurg. 2010;112(9):766–9. Dharmarajan S, et al. Out-of-pocket and catastrophic expenditure on treatment of haemophilia by Indian families. Haemophilia. 2014;20(3):382–7. Diaz M, et al. Health and economic impact of HPV 16 and 18 vaccination and cervical cancer screening in India. Br J Cancer. 2008;99(2):230–8. Donaldson EA, et al. A cost-effectiveness analysis of India’s 2008 prohibition of smoking in public places in Gujarat. Int J Environ Res Public Health. 2011;8(5):1271–86. Dorairajan N, et al. Day care surgery in a metropolitan government hospital setting—Indian scenario. Int Surg. 2010;95(1):21–6. Dranitsaris G, Truter I, Lubbe MS. The development of a value based pricing index for new drugs in metastatic colorectal cancer. Eur J Cancer. 2011;47(9):1299–304. Dranitsaris G, et al. Improving patient access to cancer drugs in India: using economic modeling to estimate a more affordable drug cost based on measures of societal value. Int J Technol Assess Health Care. 2011;27(1):23–30. Engelgau MM, Karan A, Mahal A. The economic impact of non-communicable diseases on households in India. Glob Health. 2012;8:9. Ghatak N, Trehan A, Bansal D. Financial burden of therapy in families with a child with acute lymphoblastic leukemia: report from north India. Support Care Cancer. 2016;24(1):103–8. Goldhaber-Fiebert JD, et al. Inpatient treatment of diabetic patients in Asia: evidence from India, China, Thailand and Malaysia. Diabet Med. 2010;27(1):101–8. Goyal S, et al. Risk factors and costs of oral cancer in a tertiary care hospital in Delhi. Asian Pac J Cancer Prev. 2014;15(4):1659–65. Gupta S, et al. Challenges of implementing universal newborn hearing screening at a tertiary care centre from India. Indian J Pediatr. 2015;82(8):688–93. Gupta V, et al. An analysis of the cost-effectiveness of switching from biphasic human insulin 30, insulin glargine, or neutral protamine Hagedorn to biphasic insulin aspart 30 in people with type 2 diabetes. J Med Econ. 2015;18(4):263–72. Hackenberg B, et al. Measuring and comparing the cost-effectiveness of surgical care delivery in low-resource settings: cleft lip and palate as a model. J Craniofac Surg. 2015;26(4):1121–5. Haripriya A, et al. Efficacy of intracameral moxifloxacin endophthalmitis prophylaxis at Aravind Eye Hospital. Ophthalmology. 2016;123(2):302–8. Home P, et al. An analysis of the cost-effectiveness of starting insulin detemir in insulin-naive people with type 2 diabetes. J Med Econ. 2015;18(3):230–40. Huffman MD, et al. A cross-sectional study of the microeconomic impact of cardiovascular disease hospitalization in four low- and middle-income countries. PLoS One. 2011;6(6):e20821. Jansen LA, et al. Improving patient follow-up in developing regions. J Craniofac Surg. 2014;25(5):1640–4. John RM, Sung HY, Max W. Economic cost of tobacco use in India, 2004. Tob Control. 2009;18(2):138–43. Joshi A, et al. Burden of healthcare utilization and out-of-pocket costs among individuals with NCDs in an Indian setting. J Community Health. 2013;38(2):320–7. Karan A, Engelgau M, Mahal A. The household-level economic burden of heart disease in India. Trop Med Int Health. 2014;19(5):581–91. Kesavadev J, et al. Cost-effective use of telemedicine and self-monitoring of blood glucose via Diabetes Tele Management System (DTMS) to achieve target glycosylated hemoglobin values without serious symptomatic hypoglycemia in 1,000 subjects with type 2 diabetes mellitus—a retrospective study. Diabetes Technol Ther. 2012;14(9):772–6. Khatib R, et al. Availability and affordability of cardiovascular disease medicines and their effect on use in high-income, middle-income, and low-income countries: an analysis of the PURE study data. Lancet. 2016;387(10013):61–9. Kotwani A. Availability, price and affordability of asthma medicines in five Indian states. Int J Tuberc Lung Dis. 2009;13(5):574–9. Kumar A, Gupta NP, Hemal AK. A single institution experience of 141 cases of laparoscopic radical nephrectomy with cost-reductive measures. J Endourol. 2009;23(3):445–9. Kumar A, Nagpal J, Bhartia A. Direct cost of ambulatory care of type 2 diabetes in the middle and high income group populace of Delhi: the DEDICOM survey. J Assoc Physicians India. 2008;56:667–74. Kumar GA, et al. Burden of out-of-pocket expenditure for road traffic injuries in urban India. BMC Health Serv Res. 2012;12:285. Kumpatla S, et al. The costs of treating long term diabetic complications in a developing country: a study from India. JAPI. 2013;61:17. Lahiri S, Tempesti T, Gangopadhyay S. Is There an Economic Case for Training Intervention in the Manual Material Handling Sector of Developing Countries? J Occup Environ Med. 2016;58(2):207–14. Lamy A, et al. The cost implications of off-pump versus on-pump coronary artery bypass graft surgery at one year. Ann Thorac Surg. 2014;98(5):1620–5. Levesque JF, et al. Affording what’s free and paying for choice: comparing the cost of public and private hospitalizations in urban Kerala. Int J Health Plann Manag. 2007;22(2):159–74. Linde M, Steiner TJ, Chisholm D. Cost-effectiveness analysis of interventions for migraine in four low- and middle-income countries. J Headache Pain. 2015;16:15. Lohse N, Marseille E, Kahn JG. Development of a model to assess the cost-effectiveness of gestational diabetes mellitus screening and lifestyle change for the prevention of type 2 diabetes mellitus. Int J Gynecol Obstet. 2011;115:S20–5. Lopes Gde L. Cost comparison and economic implications of commonly used originator and generic chemotherapy drugs in India. Ann Oncol. 2013;24(Suppl 5):v13–6. Mahal A, et al. The economic burden of cancers on Indian households. PLoS One. 2013;8(8):e71853. Marseille E, et al. The cost-effectiveness of gestational diabetes screening including prevention of type 2 diabetes: application of a new model in India and Israel. J Matern Fetal Neonatal Med. 2013;26(8):802–10. Megiddo I, et al. Cost-effectiveness of treatment and secondary prevention of acute myocardial infarction in India: a modeling study. Glob Heart. 2014;9(4):391.e3–398.e3. Megiddo I, et al. Health and economic benefits of public financing of epilepsy treatment in India: an agent-based simulation model. Epilepsia. 2016;57(3):464–74. Misra UK, et al. Cost of status epilepticus in a tertiary care hospital in India. Seizure. 2015;31:94–8. Muranjan M, Vijayalakshmi P. The unforeseen toll of birth defects and their economic burden at a tertiary care public institute in Mumbai. Indian J Pediatr. 2014;81(10):1005–9. Nagengast ES, et al. Providing more than health care: the dynamics of humanitarian surgery efforts on the local microeconomy. J Craniofac Surg. 2014;25(5):1622–5. Nair KS, et al. Cost of treatment for cancer: experiences of patients in public hospitals in India. Asian Pac J Cancer Prev. 2013;14(9):5049–54. Natarajan S, Rudrawar P. Bronchiectasis in western India: clinical presentations and socio-economic burden. J Indian Med Assoc. 2014;112(2):89–92. Okonkwo QL, et al. Breast cancer screening policies in developing countries: a cost-effectiveness analysis for India. J Natl Cancer Inst. 2008;100(18):1290–300. Padhi NR, Padhi P. Use of external fixators for open tibial injuries in the rural third world: panacea of the poor? Injury. 2007;38(2):150–9. Pakseresht S, et al. Expenditure audit of women with breast cancer in a tertiary care hospital of Delhi. Indian J Cancer. 2011;48(4):428–37. Patankar A, Trivedi P. Monetary burden of health impacts of air pollution in Mumbai, India: implications for public health policy. Public Health. 2011;125(3):157–64. Patel RS, et al. Cost-effectiveness analysis of nebivolol and metoprolol in essential hypertension: a pharmacoeconomic comparison of antihypertensive efficacy of beta blockers. Indian J Pharmacol. 2014;46(5):485–9. Patel V, et al. Prioritizing health problems in women in developing countries: comparing the financial burden of reproductive tract infections, anaemia and depressive disorders in a community survey in India. Trop Med Int Health. 2007;12(1):130–9. Pati S, et al. Non communicable disease multimorbidity and associated health care utilization and expenditures in India: cross-sectional study. BMC Health Serv Res. 2014;14:451. Polack S, et al. Utility values associated with diabetic retinopathy in Chennai, India. Ophthalmic Epidemiol. 2015;22(1):20–7. Prajna VN, et al. Economic analysis of corneal ulcers in South India. Cornea. 2007;26(2):119–22. Rachapelle S, et al. The cost–utility of telemedicine to screen for diabetic retinopathy in India. Ophthalmology. 2013;120(3):566–73. Raj M, et al. Micro-economic impact of congenital heart surgery: results of a prospective study from a limited-resource setting. PLoS One. 2015;10(6):e0131348. Ramachandran A. Socio-economic burden of diabetes in India. J Assoc Physicians India. 2007;55(Suppl):9–12. Ramachandran A, et al. Increasing expenditure on health care incurred by diabetic subjects in a developing country: a study from India. Diabetes Care. 2007;30(2):252–6. Ramachandran A, et al. Cost-effectiveness of the interventions in the primary prevention of diabetes among Asian Indians: within-trial results of the Indian Diabetes Prevention Programme (IDPP). Diabetes Care. 2007;30(10):2548–52. Ranade AA, et al. Clinical and economic implications of the use of nanoparticle paclitaxel (Nanoxel) in India. Ann Oncol. 2013;24(Suppl 5):v6–12. Rao GN, Bharath S. Cost of dementia care in India: delusion or reality? Indian J Public Health. 2013;57(2):71–7. Rao GN, et al. The burden attributable to headache disorders in India: estimates from a community-based study in Karnataka State. J Headache Pain. 2015;16:94. Rao KD, Bhatnagar A, Murphy A. Socio-economic inequalities in the financing of cardiovascular and diabetes inpatient treatment in India. Indian J Med Res. 2011;133:57–63. Reddy GM, et al. Extent and determinants of cost of road traffic injuries in an Indian city. Indian J Med Sci. 2009;63(12):549–56. Reddy GM, Singh A, Singh D. Community based estimation of extent and determinants of cost of injuries in a north Indian city. Indian J Med Sci. 2012;66(1–2):23–9. Reddy VK, et al. Cost-effectiveness analysis of baclofen and chlordiazepoxide in uncomplicated alcohol-withdrawal syndrome. Indian J Pharmacol. 2014;46(4):372–7. Rengasamy S, et al. Comparison of 2 days versus 5 days of octreotide infusion along with endoscopic therapy in preventing early rebleed from esophageal varices: a randomized clinical study. Eur J Gastroenterol Hepatol. 2015;27(4):386–92. Schulman-Marcus J, Prabhakaran D, Gaziano TA. Pre-hospital ECG for acute coronary syndrome in urban India: a cost-effectiveness analysis. BMC Cardiovasc Disord. 2010;10:13. Shafie AA, et al. An analysis of the short-and long-term cost-effectiveness of starting biphasic insulin aspart 30 in insulin-naïve people with poorly controlled type 2 diabetes. Diabetes Res Clin Pract. 2014;106(2):319–27. Singh A, et al. Risk factors for oral diseases among workers with and without dental insurance in a national social security scheme in India. Int Dent J. 2014;64(2):89–95. Somaiya M, et al. Changes in cost of treating schizophrenia: comparison of two studies done a decade apart. Psychiatry Res. 2014;215(3):547–53. Soudarssanane M, et al. Rheumatic fever and rheumatic heart disease: primary prevention is the cost effective option. Indian J Pediatr. 2007;74(6):567–70. Srivastava A, Mohanty SK. Age and sex pattern of cardiovascular mortality, hospitalisation and associated cost in India. PLoS One. 2013;8(5):e62134. Subramanian S, et al. Cost-effectiveness of oral cancer screening: results from a cluster randomized controlled trial in India. Bull World Health Org. 2009;87(3):200–6. Sudhindran S, et al. Cost and efficacy of immunosuppression using generic products following living donor liver transplantation in India. Indian J Gastroenterol. 2012;31(1):20–3. Suh GH, et al. International price comparisons of Alzheimer’s drugs: a way to close the affordability gap. Int Psychogeriatr. 2009;21(6):1116–26. Sur D, Mukhopadhyay SP. A study on smoking habits among slum dwellers and the impact on health and economics. J Indian Med Assoc. 2007;105(9):492–8. Tharkar S, et al. The socioeconomics of diabetes from a developing country: a population based cost of illness study. Diabetes Res Clin Pract. 2010;89(3):334–40. Tharkar S, Satyavani K, Viswanathan V. Cost of medical care among type 2 diabetic patients with a co-morbid condition—Hypertension in India. Diabetes Res Clin Pract. 2009;83(2):263–7. Trani JF, et al. Mental illness, poverty and stigma in India: a case-control study. BMJ Open. 2015;5(2):e006355. Wani MA, et al. Cost analysis of in-patient cancer chemotherapy at a tertiary care hospital. J Cancer Res Ther. 2013;9(3):397–401. Gavaza P, et al. The state of health economic research in South Africa. Pharmacoeconomics. 2012;30(10):925–40. Teerawattananon Y, Russell S, Mugford M. A systematic review of economic evaluation literature in Thailand. Pharmacoeconomics. 2007;25(6):467–79. Tran BX, et al. A systematic review of scope and quality of health economic evaluation studies in Vietnam. PLoS One. 2014;9(8):e103825. UK and India to work together on evidence-informed healthcare policy and practice. 2013. https://www.gov.uk/government/world-location-news/uk-and-india-to-work-together-on-evidence-informed-healthcare-policy-and-practice. Accessed 4 Nov 2017. Prinja S, et al. A systematic review of the state of economic evaluation for health care in India. Appl Health Econ Health Policy. 2015;13(6):595–613. Karan A, Yip W, Mahal A. Extending health insurance to the poor in India: an impact evaluation of Rashtriya Swasthya Bima Yojana on out of pocket spending for healthcare. Soc Sci Med. 2017;181(Supplement C):83–92. Bloom DE, Cafiero ET, McGovern ME, Prettner K, Stanciole A, Weiss J, Bakkila S, Rosenberg L. The economic impact of non-communicable disease in China and India: estimates, projections, and comparisons. NBER Working Paper No. 19335. http://www.nber.org/papers/w19335. Garg CC, Evans D. What is the impact of non-communicable diseases on national health expenditures: a synthesis of available data. Geneva: World Health Organization; 2011. Gupta I, Kandamuthan S, Upadhyaya D. Economic impact of cardiovascular diseases in India. New Delhi: Institute of Economic Growth University of Delhi; 2006. Mahal AS, Karan A, Engelgau M. Economic implications of non-communicable disease for India. Washington, DC: World Bank; 2010.