Echinomycin did not affect the safety of fracture healing: an experimental pilot study on a murine femur fracture model

Zimmermann SM, Würgler-Hauri CC, Wanner GA, Simmen HP, Werner CM. Echinomycin in the prevention of heterotopic ossification - an experimental antibiotic agent shows promising results in a murine model. Injury. 2013;44(4):570–5.

Ploumis A, Belbasis L, Ntzani E, Tsekeris P, Xenakis T. Radiotherapy for prevention of heterotopic ossification of the elbow: a systematic review of the literature. J Shoulder Elbow Surg. 2013;22(11):1580–8.

Balboni TA, Gobezie R, Mamon HJ. Heterotopic ossification: Pathophysiology, clinical features, and the role of radiotherapy for prophylaxis. Int J Radiat Oncol Biol Phys. 2006;65(5):1289–99.

Rath EM, Russell GV, Washington WJ, Routt ML. Gluteus minimus necrotic muscle debridement diminishes heterotopic ossification after acetabular fracture fixation. Injury. 2002;33(9):751–6.

Wan X, Shen N, Mendoza A, Khanna C, Helman LJ. CCI-779 inhibits rhabdomyosarcoma xenograft growth by an antiangiogenic mechanism linked to the targeting of mTOR/Hif-1alpha/VEGF signaling. Neoplasia. 2006;8(5):394–401.

Liu XD, Deng LF, Wang J, Qi J, Zhou Q, Wang JS, et al. The regulation of hypoxia inducible factor-1alpha on osteoblast function in postmenopausal osteoporosis. Zhonghua Wai Ke Za Zhi. 2007;45(18):1274–8.

Vanden Bossche L, Vanderstraeten G. Heterotopic ossification: a review. J Rehabil Med. 2005;37(3):129–36.

Lanas A, Perez-Aisa MA, Feu F, Ponce J, Saperas E, Santolaria S, et al. A nationwide study of mortality associated with hospital admission due to severe gastrointestinal events and those associated with nonsteroidal antiinflammatory drug use. Am J Gastroenterol. 2005;100(8):1685–93.

Perazella MA, Buller GK. NSAID nephrotoxicity revisited: acute renal failure due to parenteral ketorolac. South Med J. 1993;86(12):1421–4.

Burd TA, Hughes MS, Anglen JO. Heterotopic ossification prophylaxis with indomethacin increases the risk of long-bone nonunion. J Bone Joint Surg Br. 2003;85(5):700–5.

Schindeler A, McDonald MM, Bokko P, Little DG. Bone remodeling during fracture repair: The cellular picture. Semin Cell Dev Biol. 2008;19(5):459–66.

Stables MJ, Gilroy DW. Old and new generation lipid mediators in acute inflammation and resolution. Prog Lipid Res. 2011;50(1):35–51.

Giannoudis PV, MacDonald DA, Matthews SJ, Smith RM, Furlong AJ, De Boer P. Nonunion of the femoral diaphysis. The influence of reaming and non-steroidal anti-inflammatory drugs. J Bone Joint Surg Br. 2000;82(5):655–8.

Greenbaum MA, Kanat IO. Current concepts in bone healing. Review of the literature. J Am Podiatr Med Assoc. 1993;83(3):123–9.

Chao ST, Joyce MJ, Suh JH. Treatment of heterotopic ossification. Orthopedics. 2007;30(6):457–64. quiz 465-456.

Park JY, Park SJ, Shim KY, Lee KJ, Kim YB, Kim YH, et al. Echinomycin and a novel analogue induce apoptosis of HT-29 cells via the activation of MAP kinases pathway. Pharmacol Res. 2004;50(2):201–7.

Park YS, Shin WS, Kim SK. In vitro and in vivo activities of echinomycin against clinical isolates of Staphylococcus aureus. J Antimicrob Chemother. 2008;61(1):163–8.

Kong D, Park EJ, Stephen AG, Calvani M, Cardellina JH, Monks A, et al. Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity. Cancer Res. 2005;65(19):9047–55.

Wang R, Zhou S, Li S. Cancer therapeutic agents targeting hypoxia-inducible factor-1. Curr Med Chem. 2011;18(21):3168–89.

Gogus A, Ozturk C, Tezer M, Camurdan K, Hamzaoglu A. “Sandwich technique” in the surgical treatment of primary complex fractures of the femur and humerus. Int Orthop. 2007;31(1):87–92.

Ferreira ML, Silva PC, Alvarez Silva LH, Bonfim DC, Conilho Macedo Müller LC, Espósito CC, et al. Heterologous mesenchymal stem cells successfully treat femoral pseudarthrosis in rats. J Transl Med. 2012;10:51.

Zalavras CG, Marcus RE, Levin LS, Patzakis MJ. Management of open fractures and subsequent complications. Instr Course Lect. 2008;57:51–63.

Holstein JH, Matthys R, Histing T, Becker SC, Fiedler M, Garcia P, et al. Development of a stable closed femoral fracture model in mice. J Surg Res. 2009;153(1):71–5.

Bonnarens F, Einhorn TA. Production of a standard closed fracture in laboratory animal bone. J Orthop Res. 1984;2(1):97–101.

Histing T, Holstein JH, Garcia P, Matthys R, Kristen A, Claes L, et al. Ex vivo analysis of rotational stiffness of different osteosynthesis techniques in mouse femur fracture. J Orthop Res. 2009;27(9):1152–6.

Bhandari M, Shaughnessy S. A minimally invasive percutaneous technique of intramedullary nail insertion in an animal model of fracture healing. Arch Orthop Trauma Surg. 2001;121(10):591–3.

Oetgen ME, Merrell GA, Troiano NW, Horowitz MC, Kacena MA. Development of a femoral non-union model in the mouse. Injury. 2008;39(10):1119–26.

Holstein JH, Becker SC, Fiedler M, Scheuer C, Garcia P, Histing T, et al. Increased exercise after stable closed fracture fixation does not affect fracture healing in mice. J Biomech. 2012;45(7):1299–304.

Wang Y, Liu Y, Malek SN, Zheng P. Targeting HIF1α eliminates cancer stem cells in hematological malignancies. Cell Stem Cell. 2011;8(4):399–411.

Kambayashi S, Igase M, Kobayashi K, Kimura A, Shimokawa Miyama T, Baba K, et al. Hypoxia inducible factor 1α expression and effects of its inhibitors in canine lymphoma. J Vet Med Sci. 2015;77(11):1405–12.

Histing T, Garcia P, Holstein JH, Klein M, Matthys R, Nuetzi R, et al. Small animal bone healing models: standards, tips, and pitfalls results of a consensus meeting. Bone. 2011;49(4):591–9.

Gerstenfeld LC, Cho TJ, Kon T, Aizawa T, Cruceta J, Graves BD, et al. Impaired intramembranous bone formation during bone repair in the absence of tumor necrosis factor-alpha signaling. Cells Tissues Organs. 2001;169(3):285–94.