Eccentric exercise‐induced injuries to contractile and cytoskeletal muscle fibre components

Wiley - Tập 171 Số 3 - Trang 321-326 - 2001
Jan Fridén1, Richard L. Lieber2
1Department of Hand Surgery, Sahlgrenska University Hospital, Göteborg, Sweden
2Departments of Orthopaedics and Bioengineering, University of California and Veterans Affairs, San Diego, USA

Tóm tắt

Exercise involving lengthening of an activated muscle can cause injury. Recent reports documented the mechanics of exercise‐induced muscle injury as well as physiological and cellular events and manifestations of injury. Loss of the cytoskeletal protein desmin and loss of cellular integrity as evidenced by sarcolemmal damage occur early during heavy eccentric exercise. These studies indicate that the earliest events in muscle injury are mechanical in nature, while later events indicate that it may be more appropriate to conclude that intense exercise initiates a muscle remodeling process. We conclude that muscle injury after eccentric exercise is differently severe in muscles with different architecture, is fibre type‐specific, primarily because of fibre strain in the acute phase, and is exacerbated by inflammation after the initial injury.

Từ khóa


Tài liệu tham khảo

Armstrong R.B., 1990, Initial events in exercise‐induced muscular injury, Med Sci Sports Exerc, 22, 429

Armstrong R.B., 1983, Eccentric exercise‐induced injury to rat skeletal muscle, J Appl Physiol, 54, 90, 10.1152/jappl.1983.54.1.80

10.1111/j.1748-1716.1953.tb00988.x

10.3109/rhe1.1956.2.issue-1-4.12

10.1113/jphysiol.1995.sp020943

Belcastro A., 1993, Skeletal muscle calcium‐activated neutral protease (calpain) with exercise, J Appl Physiol, 74, 1381, 10.1152/jappl.1993.74.3.1381

10.1113/jphysiol.1976.sp011515

Chapman A.E., 1985, The mechanical properties of human muscle, Ex Sport Sci Rev, 13, 443

10.1007/BF00318400

Duan C., 1990, Rat skeletal muscle mitochondrial [Ca2+] and injury from downhill walking, J Appl Physiol, 68, 1241, 10.1152/jappl.1990.68.3.1241

Evans W.J., 1985, Metabolic changes following eccentric exercise in trained and untrained men, J Appl Physiol, 61, 1864, 10.1152/jappl.1986.61.5.1864

10.1093/ptj/73.12.911

10.1046/j.1365-201X.1996.592341000.x

10.1007/s004410051108

10.1034/j.1600-0838.2001.011002126.x

10.1007/BF01986165

10.1055/s-2008-1026030

10.1055/s-2008-1025873

10.1007/BF00635996

10.1111/j.1748-1716.1991.tb09189.x

10.1152/jappl.1995.78.2.702

Gilchrist J., 1992, Calcium‐activated neutral protease effects upon skeletal muscle sarcoplasmic reticulum protein structure and calcium release, J Biol Chem, 267, 20857, 10.1016/S0021-9258(19)36767-5

10.1098/rspb.1938.0050

10.1055/s-2008-1025758

10.1152/jappl.1998.84.2.492

10.1126/science.164.3886.1356

10.2165/00007256-198805030-00003

10.1113/jphysiol.1939.sp003756

Komi P.V., 1974, Quantitative evaluation of mechanical and electrical changes during fatigue loading of eccentric and concentric work, Scand J Rehabil Med, 3, 121

10.1055/s-2008-1026015

10.1126/science.270.5234.293

10.1111/j.1748-1716.1988.tb08446.x

10.1152/jappl.1991.70.6.2498

10.1152/jappl.1996.80.1.278

10.1111/j.1469-7793.2000.00589.x

10.1152/jappl.1985.59.1.119

10.1083/jcb.134.5.1255

10.2106/00004623-199510000-00005

10.1152/jappl.1999.87.6.2007

10.1016/0022-510X(83)90058-8

10.1042/cs0740553

Pette D.1990.The Dynamic State of Muscle Fibers. Walter de Gruyter Berlin.

Reid W., 1994, Diaphragm injury and myofibrillar structure induced by resistive loading, J Appl Physiol, 76, 176, 10.1152/jappl.1994.76.1.176

10.1152/ajpcell.2000.279.4.C1116

Singh M., 1966, Isotonic and isometric forces of forearm flexors and extensors, J Appl Physiol, 21, 1435, 10.1152/jappl.1966.21.4.1435

Stauber W.T., 1989, Eccentric action of muscles: physiology, injury, and adaptation, Ex Sport Sci Rev, 17, 157

10.1016/S0006-3495(93)81482-6

10.1113/jphysiol.1993.sp019645

10.1046/j.1365-201x.1999.00516.x

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Wiley

Tập 171 Số 3

321-326

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