Early transmissibility assessment of the N501Y mutant strains of SARS-CoV-2 in the United Kingdom, October to November 2020
Tóm tắt
Two new SARS-CoV-2 lineages with the N501Y mutation in the receptor-binding domain of the spike protein spread rapidly in the United Kingdom. We estimated that the earlier 501Y lineage without amino acid deletion Δ69/Δ70, circulating mainly between early September and mid-November, was 10% (6–13%) more transmissible than the 501N lineage, and the 501Y lineage with amino acid deletion Δ69/Δ70, circulating since late September, was 75% (70–80%) more transmissible than the 501N lineage.
Từ khóa
Tài liệu tham khảo
Leung, 2017, Monitoring the fitness of antiviral-resistant influenza strains during an epidemic: a mathematical modelling study., Lancet Infect Dis, 17, 339, 10.1016/S1473-3099(16)30465-0
Rambaut A, Loman N, Pybus O, Barclay W, Barrett J, Carabelli A, et al. Preliminary genomic characterisation of an emergent SARS-CoV-2 lineage in the UK defined by a novel set of spike mutations. Virological; 2020. Available from: https://virological.org/t/preliminary-genomic-characterisation-of-an-emergent-sars-cov-2-lineage-in-the-uk-defined-by-a-novel-set-of-spike-mutations/563
Public Health England (PHE). Investigation of novel SARS-COV-2 variant: Variant of Concern 202012/01: Technical briefing document on novel SARS-CoV-2 variant. London: PHE; 21 Dec 2020. Available from: https://www.gov.uk/government/publications/investigation-of-novel-sars-cov-2-variant-variant-of-concern-20201201
COVID-19 Genomics UK (COG-UK) Consortium. COG-UK 2020-12-20: SARS-CoV-2 in the UK. London: Microreact. [Accessed: 19 Dec 2020]. Available from: https://beta.microreact.org/project/7AJj5nS4JMCNYuxL9WCaz4-cog-uk-2020-12-20-sars-cov-2-in-the-uk/
Bloom JD. SARS-CoV-2 RBD DMS. 2020. Available from: https://jbloomlab.github.io/SARS-CoV-2-RBD_DMS/
Starr, 2020, Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding., Cell, 182, 1295, 10.1016/j.cell.2020.08.012
Teruel, 2020, Modelling conformational state dynamics and its role on infection for SARS-CoV-2 Spike protein variants, bioRxiv
COVID-19 Genomics UK (COG-UK) Consortium. Update on new SARS-CoV-2 variant and how COG-UK tracks emerging mutations. Hinxton: Wellcome Sanger Institute; 14 Dec 2020. Available from: https://www.cogconsortium.uk/news_item/update-on-new-sars-cov-2-variant-and-how-cog-uk-tracks-emerging-mutations/
Price, 2010, FastTree 2--approximately maximum-likelihood trees for large alignments., PLoS One, 5, 10.1371/journal.pone.0009490
Leung, 2020, First-wave COVID-19 transmissibility and severity in China outside Hubei after control measures, and second-wave scenario planning: a modelling impact assessment., Lancet, 395, 1382, 10.1016/S0140-6736(20)30746-7
Dong, 2020, An interactive web-based dashboard to track COVID-19 in real time., Lancet Infect Dis, 20, 533, 10.1016/S1473-3099(20)30120-1
BBC News. Covid-19: 'Our duty' to act over Christmas plans, says Matt Hancock. London: BBC News; 20 Dec 2020. Available from: https://www.bbc.com/news/uk-55382861
Rambaut, 2020, A dynamic nomenclature proposal for SARS-CoV-2 lineages to assist genomic epidemiology., Nat Microbiol, 5, 1403, 10.1038/s41564-020-0770-5
Kemp, 2020, Recurrent emergence and transmission of a SARS-CoV-2 Spike deletion ΔH69/ΔV70, bioRxiv
Kemp SA, Collier DA, Datir R, Gayed S, Jahun A, Hosmillo M, et al. Neutralising antibodies drive Spike mediated SARS-CoV-2 evasion; medRxiv 2020.
Public Health England (PHE). Investigation of novel SARS-CoV-2 variant. Variant of Concern 202012/01. Technical briefing 2. London: PHE; 2020. Available from: https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/948152/Technical_Briefing_VOC202012-2_Briefing_2_FINAL.pdf