Đánh giá khả năng lây truyền sớm của các chủng đột biến N501Y của SARS-CoV-2 tại Vương Quốc Anh, tháng 10 đến tháng 11 năm 2020
Tóm tắt
Hai dòng SARS-CoV-2 mới với đột biến N501Y trong miền liên kết thụ thể của protein gai đã lây lan nhanh chóng tại Vương Quốc Anh. Chúng tôi ước tính rằng dòng 501Y trước đó không có thiếu hụt axit amin Δ69/Δ70, lưu hành chủ yếu từ đầu tháng 9 đến giữa tháng 11, có tính lây truyền cao hơn 10% (6–13%) so với dòng 501N, và dòng 501Y có thiếu hụt axit amin Δ69/Δ70, lưu hành từ cuối tháng 9, có tính lây truyền cao hơn 75% (70–80%) so với dòng 501N.
Từ khóa
Tài liệu tham khảo
Leung, 2017, Monitoring the fitness of antiviral-resistant influenza strains during an epidemic: a mathematical modelling study., Lancet Infect Dis, 17, 339, 10.1016/S1473-3099(16)30465-0
Rambaut A, Loman N, Pybus O, Barclay W, Barrett J, Carabelli A, et al. Preliminary genomic characterisation of an emergent SARS-CoV-2 lineage in the UK defined by a novel set of spike mutations. Virological; 2020. Available from: https://virological.org/t/preliminary-genomic-characterisation-of-an-emergent-sars-cov-2-lineage-in-the-uk-defined-by-a-novel-set-of-spike-mutations/563
Public Health England (PHE). Investigation of novel SARS-COV-2 variant: Variant of Concern 202012/01: Technical briefing document on novel SARS-CoV-2 variant. London: PHE; 21 Dec 2020. Available from: https://www.gov.uk/government/publications/investigation-of-novel-sars-cov-2-variant-variant-of-concern-20201201
COVID-19 Genomics UK (COG-UK) Consortium. COG-UK 2020-12-20: SARS-CoV-2 in the UK. London: Microreact. [Accessed: 19 Dec 2020]. Available from: https://beta.microreact.org/project/7AJj5nS4JMCNYuxL9WCaz4-cog-uk-2020-12-20-sars-cov-2-in-the-uk/
Bloom JD. SARS-CoV-2 RBD DMS. 2020. Available from: https://jbloomlab.github.io/SARS-CoV-2-RBD_DMS/
Starr, 2020, Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding., Cell, 182, 1295, 10.1016/j.cell.2020.08.012
Teruel, 2020, Modelling conformational state dynamics and its role on infection for SARS-CoV-2 Spike protein variants, bioRxiv
COVID-19 Genomics UK (COG-UK) Consortium. Update on new SARS-CoV-2 variant and how COG-UK tracks emerging mutations. Hinxton: Wellcome Sanger Institute; 14 Dec 2020. Available from: https://www.cogconsortium.uk/news_item/update-on-new-sars-cov-2-variant-and-how-cog-uk-tracks-emerging-mutations/
Price, 2010, FastTree 2--approximately maximum-likelihood trees for large alignments., PLoS One, 5, 10.1371/journal.pone.0009490
Leung, 2020, First-wave COVID-19 transmissibility and severity in China outside Hubei after control measures, and second-wave scenario planning: a modelling impact assessment., Lancet, 395, 1382, 10.1016/S0140-6736(20)30746-7
Dong, 2020, An interactive web-based dashboard to track COVID-19 in real time., Lancet Infect Dis, 20, 533, 10.1016/S1473-3099(20)30120-1
BBC News. Covid-19: 'Our duty' to act over Christmas plans, says Matt Hancock. London: BBC News; 20 Dec 2020. Available from: https://www.bbc.com/news/uk-55382861
Rambaut, 2020, A dynamic nomenclature proposal for SARS-CoV-2 lineages to assist genomic epidemiology., Nat Microbiol, 5, 1403, 10.1038/s41564-020-0770-5
Kemp, 2020, Recurrent emergence and transmission of a SARS-CoV-2 Spike deletion ΔH69/ΔV70, bioRxiv
Kemp SA, Collier DA, Datir R, Gayed S, Jahun A, Hosmillo M, et al. Neutralising antibodies drive Spike mediated SARS-CoV-2 evasion; medRxiv 2020.
Public Health England (PHE). Investigation of novel SARS-CoV-2 variant. Variant of Concern 202012/01. Technical briefing 2. London: PHE; 2020. Available from: https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/948152/Technical_Briefing_VOC202012-2_Briefing_2_FINAL.pdf